Malignant transformation of eccrine tumors

Galadari, E.; Mehregan, Amir H.; Lee, K. C.

doi:10.1111/j.1600-0560.1987.tb00122.x

Cited by 91 publications

(62 citation statements)

References 17 publications

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“…[7] They follow a predictable pattern from the initial tumor site to regional lymph node and ultimately to systemic spread. [3,8] In the present case, the lesion recurred multiple times despite initial wide local excision and adjuvant radiotherapy, carried out following the first recurrence. Secondly, the lesions were slowly growing with delayed recurrent nodal and bone metastases and hence the need for prolonged follow up.…”

Section: Discussionmentioning

confidence: 96%

Malignant eccrine acrospiroma with nodal and bone metastasis

Wani¹,

Aziz²,

Mir³

et al. 2016

JCMT

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Acrospiromas are cutaneous tumors of sweat duct differentiation. Although various eccrine sweat gland tumours including benign acrospiroma are widely reviewed, malignant acrospiroma is rarely reported. Clinically, they resemble other cutaneous lesions and the primary treatment is wide local excision with or without lymph node dissection. The efficacy of adjuvant chemotherapy and radiation therapy requires further investigation.

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Section: Discussionmentioning

confidence: 96%

Malignant eccrine acrospiroma with nodal and bone metastasis

Wani¹,

Aziz²,

Mir³

et al. 2016

JCMT

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“…The clinical and radiological suspicious in this case was of a primitive breast carcinoma; the difficulty in the diagnosis of this tumor was to differentiate if the neoplasia was a skin primary or a breast one, in particular a clear cell hidradenoma, a very rare breast tumor that share the histological features of sweat gland tumors with only 18 cases reported in the literature [5], but the lacking of normal breast ductules around the tumor lobules let us to think that this case originated from the skin. Eccrine hidradenoma is an usually benign, slowly growing, asymptomatic, solid or cystic sweat gland tumour that occurs on the head, neck and limbs; the breast location is unusual, even if cases located in the trunk and in the breast were reported [5,7], and the male gender is less common [8]. When a tumor with features as ours occurs in the breast it is worthwhile to keep in mind in the differential diagnosis a skin eccrine hidradenoma, the diagnostic clue is the lobulated architecture with the two-cell pattern of proliferation, composed of polygonal cells with distinct cell border and clear cytoplasm, and dark cuboidal cells lining the duct structure [5].…”

Section: Denmark Discussionmentioning

confidence: 99%

“…The histologic appearance put in the differential diagnosis other skin neoplasms and other tumors depending on the location [3][4][5][6]. These tumors are usually benign but they can have rarely low malignant potential, and they should be surgically removed with safety margins, because they have a high local recurrence rate and a potential of malignant transformation [7].…”

Section: Introductionmentioning

confidence: 99%

Recurrent eccrine hidradenoma of the breast in a male patient: problems in differential diagnosis

Orsaria¹,

Mariuzzi²

2013

Our Dermatol Online

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Introduction: Hidradenoma is an uncommon usually benign tumor of the skin that grows slowly. Case report: We describe a case of a 39 patient with a breast mass. Physical examination revealed a solitary, well-circumscribed tumor, measuring 1 cm by 0.7 cm. No other skin abnormalities were found. A total surgical excision was performed and histologic examination concluded to an eccrine hidradenoma with clear cells. Conclusion:Here we discuss problems in the differentiate this tumor, mainly in this not common location, from a breast primary (ductal carcinoma or adenomyoepitelioma), from a metastatic clear cell carcinoma and from other types of skin tumors. Moreover, this patient presented with a recurrence of the tumor in the same location, suggesting a locally aggressive form of this neoplasia; few reports in the literature are described as at low malignant potential, but definite criteria for this diagnosis are not well defined.

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“…151 The challenge of differentiating benign from malignant variants of these tumors is further clouded by the recognized capacity of histologically banal eccrine neoplasms to transform into cancers. 198 The concept of progressive transformation of benign to malignant proliferations of epithelial and other cell types has long been recognized in other tissues in humans and in animals. It is thus possible, indeed even likely, that some cases of otherwise indolent digital papillary eccrine adenoma undergo malignant transformation as well.…”

Section: Histopathologymentioning

confidence: 99%

“…Malignant degeneration of pre-existing benign eccrine adnexal tumors is a well-described phenomenon 198,[253][254][255][256][257][258][259][260][261][262][263][264][265][266][267][268][269] and is heralded by a sudden change in tumor size or the acquisition of symptomatology such as pain or ulceration.…”

Section: Introduction and Clinical Featuresmentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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Malignant transformation of eccrine tumors

Cited by 91 publications

References 17 publications

Malignant eccrine acrospiroma with nodal and bone metastasis

Malignant eccrine acrospiroma with nodal and bone metastasis

Recurrent eccrine hidradenoma of the breast in a male patient: problems in differential diagnosis

Malignant adnexal neoplasms

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