Malignant transformation of heterotopic pancreas as middle esophagus adenocarcinoma—A rare case report and comprehensive literature review

Yang, Yong‐Bo; Liu, Yiqiang; Dai, Liang; Yan, Wanpu; Zhang, Liang; Chen, Ke‐Neng

doi:10.1111/1759-7714.14344

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…Lesion size may range from a few millimeters to as large as 4 cm. 13,14 Our patient had a very small focus of ectopic pancreatic tissue that could not be detected on radiologic examination. Even gross examination of the specimen did not reveal any definite subepithelial lesion, although the thickness of the gallbladder wall was mildly increased.…”

Section: Discussionmentioning

confidence: 86%

“…Ectopic pancreatic tissue may undergo metaplasia or even neoplastic transformation that affects the normal pancreas. 14 However, because of the low rate of malignant transformation, ranging from 0.7% to 1.8%, current recommendations do not support routine biopsy or followup screening for incidental ectopic pancreatic tissue. 14 In 2017, Vitiello et al reported that an effective treatment for symptomatic ectopic pancreatic lesions >3 cm is endoscopic mucosal resection and endoscopic submucosal dissection.…”

Section: Discussionmentioning

confidence: 99%

“…14 However, because of the low rate of malignant transformation, ranging from 0.7% to 1.8%, current recommendations do not support routine biopsy or followup screening for incidental ectopic pancreatic tissue. 14 In 2017, Vitiello et al reported that an effective treatment for symptomatic ectopic pancreatic lesions >3 cm is endoscopic mucosal resection and endoscopic submucosal dissection. 15 In most cases, surgery is the treatment of choice for the relief of symptoms and to diagnose or exclude malignancy.…”

Section: Discussionmentioning

confidence: 99%

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Ectopic Pancreatic Tissue in the Gallbladder

Kaur,

Garg,

Sharma

2024

TOJ

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Background: Ectopic pancreatic tissue, also referred to as heterotopic pancreas, is defined as the presence of pancreatic tissue in an organ outside the pancreas. Ectopic pancreatic tissue, a rare embryologic abnormality, has been reported in the stomach, duodenum, colon, and Meckel diverticulum and is usually discovered incidentally. Case Report: We report a case of ectopic pancreatic tissue in the gallbladder of a 37-year-old female who underwent a cholecystectomy after a clinical diagnosis of chronic cholecystitis. Histopathologic findings were chronic cholecystitis with cholesterolosis and pyloric metaplasia. The gallbladder wall showed ectopic pancreatic tissue composed of acini, ducts, and islets of Langerhans. The histopathologic examination confirmed the diagnosis of ectopic pancreatic tissue. Conclusion: Making a preoperative diagnosis of ectopic pancreatic tissue is clinically and radiologically challenging. Meticulous histopathologic examination is required for the diagnosis of this rare condition.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ectopic Pancreatic Tissue in the Gallbladder

Kaur,

Garg,

Sharma

2024

TOJ

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“…The proportion of heterotopic pancreas ranged from 3.4% to 4.7%, which was considered as a rare congenital abnormality during the growth and development process. Nevertheless, it has been recently reported that few unusual cases of heterotopic pancreas contributed to malignant transformations [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

The Feasibility and Safety of the Clip-and-Snare Method with a Prelooping Technique for Gastric Submucosal Tumors Removal: A Single-Center Experience (with Video)

Tang

Shi

Yao

et al. 2022

Canadian Journal of Gastroenterology and Hepatology

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Aim. This study compared the efficacy and safety of endoscopic submucosal dissection (ESD) combined with clip-and-snare method and a prelooping technique (CSM-PLT) with ESD alone for the treatment of gastric submucosal tumors (gSMTs). Methods. We retrospectively enrolled a matched group of 86 patients who received ESD combined with CSM-PLT or ESD alone from July 2010 to July 2020. The primary outcomes included complete resection, en bloc resection, and R0 resection. Results. Eighty-six patients with gSMTs were enrolled in ESD combined with CSM-PLT group and ESD group, respectively. There were no significant differences in gender, age, tumor size, tumor location, and tumor origin between the two groups. The complete resection, en bloc resection, and R0 resection rates were comparable between two groups ( P = 1 , P = 0.31 , and P = 0.25 , respectively). There were no significant differences in terms of hospital stays, hospitalization cost, postoperative complications, and residual rate ( P = 0.42 , P = 0.74 , P = 0.65 , and P = 1 , respectively) between the two groups. However, the ESD combined with CSM-PLT was associated with a shorter procedure duration and fewer intraoperative complications ( P < 0.001 and P = 0.024 , respectively). In addition, the incidence of intraoperative bleeding in ESD combined with CSM-PLT group was significantly lower than that in ESD group ( P = 0.04 ). Conclusion. Both ESD combined with CSM-PLT and ESD were effective and safe modalities for the treatment of gSMTs. However, ESD combined with CSM-PLT was associated with a shorter procedure duration and fewer intraoperative complications.

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“…The following three criteria are recommended for diagnosing cancer originating from ectopic pancreatic tissues: (1) the tumor is present within or close to the ectopic pancreatic tissue, (2) direct transition is observed between the pancreatic structures and carcinoma, and (3) nonneoplastic pancreatic tissue must comprise at least fully developed acini and ductal structures 20 . A previous 8 study reported adenocarcinoma arising from ectopic pancreatic tissue in the esophagus and non-neoplastic ectopic pancreatic tissue in the surrounding area 21 . As our case occurred in the midline of the thoracic cavity, we suspected that it may have originated from ectopic pancreatic tissue in the esophagus.…”

Section: Textmentioning

confidence: 99%