Malignant transformation of meningeal melanocytoma: A case report

Uozumi, Yoichi; Kawano, Teruaki; Kawaguchi, Tsutomu; Kaneko, Y; Ooasa, Takao; Ogasawara, Sadanobu; Yoshida, Hidenori; Yoshida, Takashi

doi:10.1007/bf02478943

Cited by 69 publications

(51 citation statements)

References 23 publications

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“…Especially in case of incomplete resection, melanocytomas frequently recur (up to 50% recurrence reported 1 year after surgery) (108). Also, aggressive behavior with leptomeningeal seeding or rarely malignant transformation into melanoma has been reported (20,72,108,132). Whenever possible, melanocytomas should be completely resected.…”

Section: Melanocytomamentioning

confidence: 97%

Primary Melanocytic Tumors of the Central Nervous System: a Review with Focus on Molecular Aspects

Küsters‐Vandevelde

Küsters

Grunsven³

et al. 2015

Brain Pathology

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Primary melanocytic tumors of the central nervous system (CNS) represent a spectrum of rare tumors. They can be benign or malignant and occur in adults as well as in children, the latter often in the context of neurocutaneous melanosis. Until recently, the genetic alterations in these tumors were largely unknown. This is in contrast with cutaneous and uveal melanomas, which are known to harbor distinct oncogenic mutations that can be used as targets for treatment with small-molecule inhibitors in the advanced setting. Recently, novel insights in the molecular alterations underlying primary melanocytic tumors of the CNS were obtained, including different oncogenic mutations in tumors in adult patients (especially GNAQ, GNA11) vs. children (especially NRAS). In this review, the focus is on molecular characteristics of primary melanocytic tumors of the CNS. We summarize what is known about their genetic alterations and discuss implications for pathogenesis and differential diagnosis with other pigmented tumors in or around the CNS. Finally, new therapeutic options with targeted therapy are discussed.

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Section: Melanocytomamentioning

confidence: 97%

Primary Melanocytic Tumors of the Central Nervous System: a Review with Focus on Molecular Aspects

Küsters‐Vandevelde

Küsters

Grunsven³

et al. 2015

Brain Pathology

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“…Two separate biopsies were thought to contain only benign melanocytoma cells and the enucleated eye contained residual melanocytoma-like cells, so it is conceivable that de-differentiation to melanoma had occurred over time, or that the initial samples had missed a deeper small ciliary-body lesion. Malignant transition from melanocytoma of the optic disc,3 4 choroid,5 6 ciliary body7 and meninges8 has been described, but malignant transformation of iris melanocytoma was not found in one series at 5 years 1. However, Cialdini et al 2 reported a discrete, rather than ring configuration, iris tumour that contained malignant and melanocytoma cells.…”

Section: Commentmentioning

confidence: 99%

Malignant transformation of iris melanocytoma to iris ring melanoma

Sagoo

Mruthyunjaya

Cree

et al. 2007

British Journal of Ophthalmology

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“…Radiation therapy is reserved for cases in which complete resection is not possible or in which there is a recurrence(40). There have been reports of melanocytomas transforming into malignant melanoma, spreading along the leptomeninges, and even demonstrating distant metastasis(34,(41)(42)(43).…”

mentioning

confidence: 99%

Pigmented Lesions of the Central Nervous System: Radiologic-Pathologic Correlation

Smith¹,

Rushing²,

2009

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Pigmented lesions of the central nervous system (CNS) are a diverse group of entities that run the gamut from benign to malignant. These lesions may be well circumscribed or diffuse, and their imaging appearances are influenced by the degree of melanin content as well as the presence or absence of hemorrhage. Pigmented lesions include primary melanocytic lesions of the CNS and metastatic melanoma, as well as other CNS neoplasms that may undergo melanization, including schwannoma, medulloblastoma, and some gliomas. Primary melanocytic lesions of the CNS arise from melanocytes located within the leptomeninges, and this group includes diffuse melanocytosis and meningeal melanomatosis (seen in neurocutaneous melanosis), melanocytoma, and malignant melanoma. Primary melanin-containing lesions of the CNS must be differentiated from metastatic melanoma because these lesions require different patient workup and therapy. Absence of a known primary malignant melanoma helps in the differential diagnosis, but an occult primary lesion outside the CNS must be sought and excluded. Pigmented lesions of the CNS are uncommon, and knowledge of their imaging characteristics and pathologic features is essential for their identification.

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Malignant transformation of meningeal melanocytoma: A case report

Cited by 69 publications

References 23 publications

Primary Melanocytic Tumors of the Central Nervous System: a Review with Focus on Molecular Aspects

Primary Melanocytic Tumors of the Central Nervous System: a Review with Focus on Molecular Aspects

Malignant transformation of iris melanocytoma to iris ring melanoma

Pigmented Lesions of the Central Nervous System: Radiologic-Pathologic Correlation

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