Malignant transformation of oral leukoplakia treated with carbon dioxide laser: a meta-analysis

Dong, Yunmei; Chen, Yuxin; Yan, Tao; Hao, Yilong; Jiang, Lu; Dan, Hongxia; Zeng, Xin; Chen, Qianming; Zhou, Yu

doi:10.1007/s10103-018-2674-7

Cited by 25 publications

(21 citation statements)

References 43 publications

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“…c If a patient has other sites of oral leukoplakia in addition to tongue, the patient will be categorized as "yes" malignant changes of OLK, similar conflict between the published reports was also found; oral habits were significant factors in some academic works [5,29,39] and non-significant in others [21,38,[40][41][42]. In the present study, oral habits were not factors related to the recurrence or malignant transformation of oral tongue leukoplakia.…”

Section: Discussionsupporting

confidence: 68%

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

et al. 2021

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Objectives The tongue is identified as a high-risk site for oral leukoplakia and malignant transformation. The purpose of this study is to investigate the clinicopathological characteristics and treatment outcomes of tongue leukoplakia and assess the factors related to recurrence and malignant transformation. Materials and methods One hundred and forty-four patients who received carbon dioxide laser surgery for tongue leukoplakia from 2002 to 2019 were analyzed statistically. Results The follow-up period was 54.90 ± 54.41 months. Thirty patients showed postoperative recurrence (20.83%), and 12 patients developed malignant transformation (8.33%). The annual transformation rate was 2.28%. Univariate analysis showed that a history of head and neck cancer, size of lesion area, clinical appearance, and pathology were significant factors for both recurrence and malignant transformation. In the multivariate logistic regression, a history of head and neck cancer and size of lesion area were independent prognostic factors for recurrence, and a history of head and neck cancer was the only independent factor for postoperative malignant change. Conclusions Clinicians should adopt more aggressive strategies for tongue leukoplakia patients with a history of head and neck cancer. Clinical relevance These results may help clinicians gain a better understanding of oral tongue leukoplakia.

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Section: Discussionsupporting

confidence: 68%

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

et al. 2021

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“…This is significant because the reading of the margins must be guaranteed in case of potentially malignant epithelial lesions, which can infiltrate tissues in depth and for which it is essential to understand if the pathological tissue has been completely excised [25,26]. In order not to run into this problem, the gold standard for suspicious lesions remains the cold blade, but alternatively the incision can be spaced, depending on the wavelengths used, at least 0.5 mm away from clinically visible pathological tissue [27,28]. Therefore, it is essential to correctly identify unsuspicious lesions by differentiating them from potentially malignant lesions, based on semiological criteria, identifying clinical diagnostic suspects that will be confirmed, or not, by histological examination; for this reason, clinicians should be qualified in oral pathology [29].…”

Section: Discussionmentioning

confidence: 99%

Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy

Palaia

Pergolini

D’Alessandro

et al. 2020

IJERPH

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Continuously evolving laser devices can be used in various fields; they are an alternative to the traditional cold blade surgery to perform biopsies of oral soft tissues. The aspect focused on in this paper is the possibility to use the 445 nm diode laser (Eltech K-Laser srl, Treviso, Italy) in complete safety, by evaluating its thermal effects during microscopy. A histological evaluation of the alteration of the peri-incisional edges on 10 samples was realized. All excisional biopsies were related to clinically unsuspected lesions and performed by the same expert operator. The surgical procedure was performed with the same laser parameters and the same pathologist evaluated the thermal effect on the samples. An average value of the detected tissue alteration was calculated; the average damage of the epithelium was 650.93 μm, while in the connective tissue it was 468.07 μm. In all the cases a clear diagnosis was possible, and no clinical complications were observed; so, the 445 nm diode laser proved to be a device that can be safely used for biopsies of clinically unsuspicious lesions. Due to the small number of cases, this in vivo preliminary experience needs to be extended.

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“…Regarding surgical treatment as a tool to reduce malignant transformation of OL, it was reported as being effective in some studies, but others had conflicting results . A report in the Cochrane Database of Systematic Review also indicated that there was no randomized clinical trial that has included a no treatment or placebo comparison group in investigating the role of surgical treatment for OL .…”

Section: Discussionmentioning

confidence: 99%

Clincopathological characteristics and treatment outcomes of oral leukoplakia by carbon dioxide laser excision in the elderly patients

et al. 2020

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Background: Older age is one of the factors associated with malignant transformation of oral leukoplakia (OL). The purpose of this study is to analyze the clincopathological features and treatment outcomes of OL in the elderly patients.Methods: The demographic data and histopathological results of the patients (age ≥ 65) who received carbon dioxide laser surgery for OL from 2002 to 2017 were analyzed statistically. Results: There were 53 males and 16 females, with a mean age 71.2 ± 4.9. The follow-up time was 42.5 ± 35.2 months. In the univariate analysis, morphology, pathology, and area were found to be factors associated with postoperative recurrence. Among these factors, pathology and area were the independent predictive factors for recurrence in the multivariate logistic regression model. Malignant transformation occurred in 8 of 69 patients (11.6%). Conclusions:The pathological high-risk dysplasia and area of OL were the two prognostic factors for postoperative recurrence. K E Y W O R D S elderly, laser, malignant transformation, oral leukoplakia, recurrence

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Malignant transformation of oral leukoplakia treated with carbon dioxide laser: a meta-analysis

Cited by 25 publications

References 43 publications

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy

Clincopathological characteristics and treatment outcomes of oral leukoplakia by carbon dioxide laser excision in the elderly patients

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