Malignant transformation of oral lichen planus in lingual location: report of a case

Gándara-Rey, José Manuel; Diniz‐Freitas, Márcio; Vila, Pilar Gándara; Carrión, Andrés Blanco; Peñaranda, José Manuel Suárez; Garcı́a, Abel Garcı́a

doi:10.1016/s1741-9409(03)00002-5

Cited by 9 publications

(9 citation statements)

References 18 publications

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“…Case reports are of limited value and obviously can only serve as hypothesis generators. 19 Examples of these studies are GándaraRey et al, 20 Katz et al, 21 and Tovaru et al 22 Retrospective studies are mostly performed after completion of the surveillance period, and therefore, contain errors, work with incomplete information which has not been defined prior to examination, or in followup with the patients. 19 Such articles can be found at these references.…”

Section: Review Resultsmentioning

confidence: 99%

Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Agha‐Hosseini

Sheykhbahaei

Sadrzadeh-Afshar

2016

The Journal of Contemporary Dental Practice

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Section: Review Resultsmentioning

confidence: 99%

Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Agha‐Hosseini

Sheykhbahaei

Sadrzadeh-Afshar

2016

The Journal of Contemporary Dental Practice

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“…In addition most literature sources point erosive and atrophic forms as carrying the highest malignant risk. 3,4,23 In the present study six patients with erosive form, five patients with atrophic form and one patient with bullous-erosive form were included. According to the results obtained in this study, a downward shift of the VAS score after LLLT occurred in all of the patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of Low Level Laser Therapy on Erosive-atrophic Oral Lichen Planus

Mutafchieva¹,

Draganova-Filipova²,

Zagorchev³

et al. 2018

Folia Medica

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Background: The erosive-atrophic form of oral lichen planus (OLP) is associated with severe pain and burning sensation and is often unresponsive to treatment. Topical corticosteroids are considered as a medication of first choice but they can produce adverse effects. Therefore, new therapeutic approaches are required. Aim: The aim of this study was to investigate the effectiveness of biomodulation with diode laser in patients presenting with long-standing erosive-atrophic OLP. Materials and methods: Twelve patients, clinically and histologically diagnosed with OLP, participated in this study. The level of pain and the clinical scores of total 59 lesions were recorded before treatment using visual analog scale and Thongprasom sign scoring system respectively. All patients received low level laser therapy (LLLT) with diode laser (810 nm) with parameters (0.5 W, 30 s, 1.2 J/cm2) three times weekly for a month. The response rate was assessed according to the decrease in pain and sign scores. Treatment efficacy index was calculated. Results: There was a significant reduction in pain after LLLT (p<0.0001). Improvement in clinical signs was achieved in 59.3% of the lesions. At the end of the treatment 5.1% of the lesions exhibited score 5; 6.8% - score 4, 11.9% of the lesions were scored 3 and 8.5% and 30.5% showed score 2 and score 1, respectively. Complete resolution was revealed in 37.3% of the lesions. All patients experienced some degree of improvement. Most of the cases showed moderate recovery. Conclusion: The present results indicate that LLLT is an effective and harmless modality for management of erosive-atrophic OLP.

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“…1,48 Most literature sources point erosive and atrophic forms as carrying the highest risk. 1,2,49 A recent metaanalysis on the topic demonstrated that regarding the potential for conversion into oral cancer, various forms of OLP have almost the same percentage distribution. 48 Therefore, timely diagnosis and regular follow-up of patients with OLP are vital.…”

Section: Malignant Potentialmentioning

confidence: 99%

Oral Lichen Planus – Known and Unknown: a Review

et al. 2018

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Lichen planus is a chronic mucocutaneous inflammatory disease aff ecting 1-2% of the general population with maximum prevalence of the disease in women above the age of 40. Its aetiology remains unclear and the pathogenesis is still the object of much speculation. It is considered to be an autoimmune disorder mediated mainly by the T-lymphocytes. The present paper presents the most well-known external agents (viruses in particular), internal agents like stress, and the heat shock protein thought to be trigger factors and describes the action of diff erent cells and proteins associated with the development of that disease. Diagnosis is based on clinical and histopathologic evidence; direct and indirect immunofluorescence techniques can also be of use. Despite the wide variety of therapeutic modalities, treatment outcomes are often insufficient. Currently, topical corticosteroids are widely accepted as a standard therapy, but also retinoids, calcineurin inhibitors and other immunosuppressants can be administered. Because of the aspect relevant to these drugs, priority is given to alternative harmless methods such as LLLT and PDLT. There is an ongoing controversy in the literature about the possible premalignant character of oral lichen planus, however, periodic followup is recommended.

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Malignant transformation of oral lichen planus in lingual location: report of a case

Cited by 9 publications

References 18 publications

Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Effects of Low Level Laser Therapy on Erosive-atrophic Oral Lichen Planus

Oral Lichen Planus – Known and Unknown: a Review

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