Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population‐based retrospective cohort study

Abstract

Oral submucous fibrosis patients exhibited a significantly higher risk of malignant transformation than those without OSF. OL could enhance malignant transformation in patients with OSF.

Experimental study on TGF‐β1‐mediated CD147 expression in oral submucous fibrosis

“…Oral leukoplakia, oral erythroplakia, and oral lichen planus are usually associated with OSF and increase the risks of oral malignancy. According to a recent study among 778 cases of OSF in Taiwan, the incidence of malignant transformation was 9.13%, with an average duration of 13 years (Yang et al., ). Meanwhile, the transformation rate was 7.6% after 17 years of follow‐up in an Indian study (Murti et al., ).…”

Malignant development in patients with oral potentially malignant disorders detected through nationwide screening: Outcomes of 5‐year follow‐up at a single hospital

“…12,32 A study using the Taiwan National Health Insurance database indicated that the malignant development rate of OSF accompanied by leukoplakia (15.7%) was higher than that of OSF alone (7.0%). 33 Of the 27 OSF cases with accompanying leukoplakia in this study, 48% underwent surgery. As a result, the carcinoma development rate in OSF cases with accompanying leukoplakia was 18.5%, which was significantly higher than the 4.6% found in patients with OSF alone.…”

Growth‐regulated oncogene‐α from oral submucous fibrosis fibroblasts promotes malignant transformation of oral precancerous cells

“…Oral submucous fibrosis (OSF) is one of the oral precancerous lesions with high incidence of malignant transformation and rising global prevalence . The malignant transformation rate of OSF has been reported to be around 9%~26% . Therefore, to explore the molecular mechanisms of this disease may help us identify new therapeutic targets.…”

“…2 The malignant transformation rate of OSF has been reported to be around 9% 26%. 3,4 Therefore, to explore the molecular mechanisms of this disease may help us identify new therapeutic targets.…”