Malignant transformation rate in oral submucous fibrosis over a 17‐year period

Murti, P. R.; Bhonsle, R. B.; Pindborg, J. J.; Daftary, D. K.; Gupta, Prakash C.; Mehta, Fali S.

doi:10.1111/j.1600-0528.1985.tb00468.x

Cited by 329 publications

(233 citation statements)

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“…Incidence of malignant transformation of OSMF was found to be 4.23 % in the present study which is significantly higher than few studies carried out in the past, but is in conformity with the studies of Pindborg et al [19] in 1984, whereas less than the incidence found by Murti et al [14] in 1985. Both these studies were carried out in the Indian subcontinent, where betel nut chewing with or without tobacco is commonly seen in the society.…”

Section: Discussionsupporting

confidence: 90%

“…OSMF is also found to be associated with other premalignant lesions [14,19] like leukoplakia and erythroplakia and in the present study the incidence of the same was found to be 11 %. Normally in the OSMF, the oral mucous membrane is found to be severely atrophic and development of such lesions like leukoplakia and erythroplakia associated with acanthosis and proliferation of epithelial lining warrants serious thought and early intervention, as it could be a transition from fibrosis to a frank squamous cell carcinoma.…”

Section: Discussionsupporting

confidence: 70%

“…It has been suggested that ingestion of chillies, genetic susceptibility, nutritional deficiencies, altered salivary constituents, autoimmunity and collagen disorders may be involved in the pathogenesis of this condition [7]. The condition is well recognized for its significant malignant potential, the incidence of which varies from one region to another, as shown by a number of studies [9][10][11][12][13][14]. Pindborg [13] in 1980, from a series of epidemiological surveys conducted in India and South Africa found malignant change in 3 to 6 % of patients having OSMF.…”

Section: Introductionmentioning

confidence: 99%

“…Pindborg [13] in 1980, from a series of epidemiological surveys conducted in India and South Africa found malignant change in 3 to 6 % of patients having OSMF. In 1985, Murti et al [14] assessed malignant transformation rate of 7.6 % in a 10-year mean observation period.…”

Section: Introductionmentioning

confidence: 99%

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Concomitant Association of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma and Incidence of Malignant Transformation of Oral Submucous Fibrosis in a Population of Central India: A Retrospective Study

Chourasia

Borle²,

Vastani

2015

J. Maxillofac. Oral Surg.

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Aim To evaluate the incidence of oral squamous cell carcinoma concomitant with oral sub mucous fibrosis in central India and to correlate precipitating factors associated with oral submucous fibrosis and oral squamous cell carcinoma. This paper also aims to study the incidence of oral squamous cell carcinoma arising secondary to untreated oral submucous fibrosis. Materials and Methods Two hundred and twenty five cases of oral squamous cell carcinoma and one hundred and nineteen cases of oral submucous fibrosis of various regions in oral cavity were included in the study. All the included cases were clinically and histopathologically diagnosed and retrospective data was retrieved. Result In the present study of 119 patients of oral submucous fibrosis, 97.4 % were found to have betel nut chewing habit. Incidence of malignant transformation to oral squamous cell carcinoma in patients of untreated oral submucous fibrosis was found to be 4.2 % in the present study. The incidence of oral cancer concomitant with oral submucous fibrosis was found to be 25.77 %, which is statistically significant. Conclusion From the present study, it is evident that the malignant potential of OSF is underestimated. However, considering the small sample size and the fact that the study was carried out in a small geographical area, further study with a larger sample size and longer duration of follow up on a multicentric basis may be required to reveal the actual malignant potential of the disease.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Concomitant Association of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma and Incidence of Malignant Transformation of Oral Submucous Fibrosis in a Population of Central India: A Retrospective Study

Chourasia

Borle²,

Vastani

2015

J. Maxillofac. Oral Surg.

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“…Its precancerous nature was first described by Paymaster [2], who recorded the onset of slowly growing squamous cell carcinomas in one-third of patients with it. Minti et al reported a malignant transformation rate of 7.6% [3].…”

Section: Introductionmentioning

confidence: 99%

Extended Nasolabial Flaps in the Management of Oral Submucous Fibrosis

Agarwal¹,

Gupta²,

Tiwari³

2011

J. Maxillofac. Oral Surg.

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Purpose We evaluated the use of extended nasolabial flaps in the management of oral submucous fibrosis. Methods We evaluated the use of extended nasolabial flaps in the management of 27 randomly selected patients with histologically confirmed oral submucous fibrosis. They all had interincisal opening of less than 20 mm and were treated by bilateral release of fibrous bands and extended grafting with a nasolabial flap. All patients had postoperative physiotherapy, and were followed up for one year.Results Their interincisal opening improved significantly from a mean of 11mm (range 3-19) to a mean of 39 mm (range 23-48). Conclusions The procedure was effective in the management of patients with oral submucous fibrosis, the main disadvantage being the extraoral scars.

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An epidemiologic assessment of cancer risk in oral precancerous lesions in India with special reference to nodular leukoplakia

Gupta

Bhonsle

Murti

et al. 1989

Cancer

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148

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A cohort of 12,212 tobacco users was followed up annually to assess malignant potential of oral precancerous lesions in the Ernakulam district in Kerala, India. A total of 19 new oral cancers were diagnosed over a period of 8 years, and 15 (79%) of these arose from some preexisting precancerous lesion or condition. Nodular leukoplakia showed highest rate of malignant transformation (16% per year) as six of 13 nodular leukoplakia underwent malignant transformation over a mean follow-up period of 2.8 years. The relative risk (3243.2) compared with individuals with tobacco habits but without any precancerous oral lesion was also the highest for nodular leukoplakia. In addition, nodular leukoplakia was associated with submucous fibrosis in two patients, which progressed to oral cancer and was the clinical diagnosis for four lesions that turned out to be malignant on histopathologic examination. Nodular appearance was noted in two other precursor lesions as well. Thus, 14 of 19 oral cancers (74%) were either preceded by nodular leukoplakia and with lesions showing a distinct nodular appearance, or had the clinical appearance of nodular leukoplakia.

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Malignant transformation rate in oral submucous fibrosis over a 17‐year period

Cited by 329 publications

References 1 publication

Concomitant Association of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma and Incidence of Malignant Transformation of Oral Submucous Fibrosis in a Population of Central India: A Retrospective Study

Concomitant Association of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma and Incidence of Malignant Transformation of Oral Submucous Fibrosis in a Population of Central India: A Retrospective Study

Extended Nasolabial Flaps in the Management of Oral Submucous Fibrosis

An epidemiologic assessment of cancer risk in oral precancerous lesions in India with special reference to nodular leukoplakia

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