Malignant tumors arising in patients with congenital bone diseases —Investigation by a questionnaire

Tsuruta, Toyoshi; Ogihara, Yoshito

doi:10.1007/bf01876755

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1985

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“…Increased chromosomal instability in patients with bone defects and connective tissue disorders has been reported previously. Tendency to malignancy in bone dysplasias has also been noted (Tsuruta & Ogihara 1984). We wonder whether a connection may exist between these observations and whether this family may be at risk for malignancy.…”

Section: S H a B T A I E T A Lmentioning

confidence: 95%

Familial syndrome with some features of the Langer‐Giedion syndrome, and paracentric inversion of chromosome 8, inv 8 (q11.23<q21.1)

et al. 1985

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A family is reported with an autosomal dominant inherited syndrome presenting some of the typical features of the tricho‐rhino‐phalangeal syndrome type II (TRP II) or Langer‐Giedion syndrome. The critical region for the expression of the syndrome seems to be at band 8q24.1. In the affected members of the family reported here, anomaly of chromosome 8 was noted, involving however the proximal part of the 8 long arm, which was interpreted as a paracentric inversion. Whether the anomaly is causally or only casually related to the syndrome is a matter of discussion.

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Section: S H a B T A I E T A Lmentioning

confidence: 95%