Malignant Tumors of Salivary Glands

Spiro, Ronald H.; Lim, Dennis

doi:10.1007/0-387-21701-0_9

Cited by 45 publications

(63 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although postoperative radiotherapy was not found to affect local control or survival by either univariate or multivariate analysis, the overall rate of its administration (42/50; 84%) was apparently higher than the rate found in other series. 3,6 The rates of local failure in this study (crude rate, 22.0%; 5-year actuarial rate, 22.8%) is more similar to the reported local failure rates after the administration of postoperative radiotherapy for high-grade tumours (14%-30%) 1,2,5 than to the reported local failure rates after surgical resection alone (43%-50%). 1,2,5 Even after excluding cases of LELC and acinic cell carcinoma, the 5-year actuarial local failure rate of 25.2% and the 5-year RFS rate of 57.4% were among the lowest and highest, respectively, in the literature; most studies have reported a 5-year RFS rate between 31% and 58%.…”

Section: P=00023supporting

confidence: 81%

“…The prognostic significance of the N-stage has also been highlighted in many previous reports. 3,4,[6][7][8][9][10]15 In contrast, the T-stage, its a-and …”

Section: Discussionmentioning

confidence: 99%

“…1,2 The mainstay of treatment is surgical resection. Postoperative radiotherapy is indicated when the resection margin is positive or close, 3,4 the tumour is high grade, 3,4 there is tumour infiltration of adjacent organs, or regional metastasis is extensive. 5,6 The prognosis depends on the stage [5][6][7][8] and grade 3,4,9 of the cancer, the completeness of surgical resection, and, when the resection is incomplete, whether or not postoperative radiotherapy is administered.…”

Section: Introductionmentioning

confidence: 99%

“…Postoperative radiotherapy is indicated when the resection margin is positive or close, 3,4 the tumour is high grade, 3,4 there is tumour infiltration of adjacent organs, or regional metastasis is extensive. 5,6 The prognosis depends on the stage [5][6][7][8] and grade 3,4,9 of the cancer, the completeness of surgical resection, and, when the resection is incomplete, whether or not postoperative radiotherapy is administered. [1][2][3]6,10 Unlike other high-grade salivary gland carcinomas, lymphoepithelioma-like carcinomas (LELCs) are very radiosensitive, [11][12][13] and radiotherapy has been used instead of surgery as the primary treatment of LELC.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 The prognosis depends on the stage [5][6][7][8] and grade 3,4,9 of the cancer, the completeness of surgical resection, and, when the resection is incomplete, whether or not postoperative radiotherapy is administered. [1][2][3]6,10 Unlike other high-grade salivary gland carcinomas, lymphoepithelioma-like carcinomas (LELCs) are very radiosensitive, [11][12][13] and radiotherapy has been used instead of surgery as the primary treatment of LELC. 11 In addition, the prognosis of LELC in Hong Kong is good: the 5-year control rate exceeds 90% and the 4-year disease-free survival rate is higher than 80%.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Salivary Gland Carcinoma

Mehanna¹,

Ang²

2012

Head and Neck Cancer Recurrence

View full text Add to dashboard Cite

Objectives. To investigate the failure patterns and the prognostic factors following postoperative radiotherapy for salivary gland carcinoma. Design. Retrospective study. Setting. University teaching hospital, Hong Kong. Patients. Fifty patients who had non-disseminated salivary gland carcinoma and who received primary treatment from 1984 through 1993. Main outcome measures. Demographic data, cancer T-and N-stages, histological type, site of origin, completeness of surgery, whether postoperative radiotherapy was given, and the clinical outcome. Results. Two (4%) patients had been treated with radiotherapy alone, six (12%) had undergone radical resection alone, and 42 (84%) had been radically treated by using both modalities. The 5-year overall survival and relapse-free survival rates were 78.4% and 63.1%, respectively. The free from local failure and free from distant metastasis rates at 5 years were 77.2% and 72.8%, respectively. The N-stage was a significant prognostic factor. The site of the primary tumour, T-stage, completeness of surgery, and use of postoperative radiotherapy were not significant independent prognosticators; however, among the T-stage tumours, the b-substage carcinomas had significantly fewer local failures (P=0.040) and better survival rates (P=0.038) than the a-substage carcinomas. There were seven (14%) locoregional failures without distant metastasis, seven (14%) cases of distant metastasis without locoregional failures, and four (8%) locoregional failures preceding distant metastasis; isolated regional relapse was rare (1/50; 2%). All regional failures (5/50; 10%) occurred ipsilateral to the primary lesion. There were no deaths due to lymphoepithelioma-like carcinoma or acinic cell carcinoma. Conclusions. The N-stage is the main prognostic factor of overall survival, relapse-and metastasis-free recovery, and success of treatment for salivary gland carcinoma. Optimal locoregional treatment can help reduce distant metastasis, and the maximal use of postoperative radiotherapy may contribute to improved locoregional control. Elective ipsilateral neck radiotherapy is indicated for lymphoepithelioma-like carcinoma.

show abstract

Section: P=00023supporting

confidence: 81%

“…The prognostic significance of the N-stage has also been highlighted in many previous reports. 3,4,[6][7][8][9][10]15 In contrast, the T-stage, its a-and …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Salivary Gland Carcinoma

Mehanna¹,

Ang²

2012

Head and Neck Cancer Recurrence

View full text Add to dashboard Cite

show abstract

Five- and 10-Year Cause-Specific Survival Rates in Carcinoma of the Minor Salivary Gland

Baddour

Fedewa

Chen

2016

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

Myoepithelial cell-rich neoplasms: Cytologic features of benign and malignant lesions

Darvishian

Lin

2004

Cancer

View full text Add to dashboard Cite

BACKGROUND Lesions that contain abundant myoepithelial cells may present as a diagnostic challenge in fine‐needle aspiration (FNA) specimens. Potential diagnostic problems may arise due to morphologic heterogeneity of myoepithelial cell‐rich lesions and difficulty in predicting malignancy in FNA specimens. An accurate diagnosis is important, because malignant myoepithelial cell‐rich lesions require a wider local excision and lymph node dissection. The authors characterized the cytologic features of myoepithelial cell‐rich lesions in an attempt to define the criteria that facilitate distinction between benign and malignant tumors. METHODS FNA biopsies of myoepithelial cell‐rich lesions with corresponding histologic specimens were selected. The cytology specimens were evaluated for the following criteria: cellularity, cell morphology, pleomorphism, chromatin pattern, presence of nucleoli, background material, necrotic debris, and presence of mitotic figures. A review of the histologic sections was performed for diagnostic confirmation. RESULTS Seventeen specimens from 17 different patients were selected. The histologic diagnoses were myoepithelial carcinoma (n = 6 patients), malignant mixed tumor with predominant myoepithelial carcinoma (n = 2 patients), epithelial‐myoepithelial carcinoma (n = 1 patient), and benign mixed tumor (n = 8 patients). The primary sites included the parotid gland (n = 10 patients), submandibular gland (n = 3 patients), minor salivary gland (n = 3 patients), and breast (n = 1 patient). Most specimens, whether they were benign or malignant, were very cellular. Pleomorphism, coarse chromatin, prominent nucleoli, mitotic figures, and necrosis were observed only in malignant specimens. Background material and ductal cells were seen in both benign and malignant specimens. CONCLUSIONS The presence of pleomorphism, coarse chromatin, prominent nucleoli, mitotic figures, and/or necrosis should raise the possibility of myoepithelial carcinoma in FNA specimens from myoepithelial cell‐rich lesions. Cancer (Cancer Cytopathol) 2004. © 2004 American Cancer Society.

show abstract

Malignant Tumors of Salivary Glands

Cited by 45 publications

References 11 publications

Salivary Gland Carcinoma

Salivary Gland Carcinoma

Five- and 10-Year Cause-Specific Survival Rates in Carcinoma of the Minor Salivary Gland

Myoepithelial cell-rich neoplasms: Cytologic features of benign and malignant lesions

Contact Info

Product

Resources

About