Malignant tumours of the foot and ankle

Rammelt, Stefan; Fritzsche, Hagen; Hofbauer, Christine; Schaser, Klaus‐Dieter

doi:10.1016/j.fas.2019.05.005

Cited by 30 publications

(45 citation statements)

References 59 publications

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“…Previous reports in the literature are lacking meaningful prognostic information due to limited small sample sizes of malignant bone tumors. 1,2,9,12,14,[17][18][19][20]31 Univariate analysis in the current study showed older age, poor or undifferentiated grade, distant stage, size ≥8 cm, histology other than chondrosarcoma, surgical treatment other than local excision, and an earlier decade of diagnosis were found to be associated with poor outcomes. Of these, younger age group and localized stage, were found to be independent predictors of improved outcomes.…”

Section: Resultsmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

“…The human foot has unique anatomical characteristics that facilitate weight bearing, upright posture and bipedal gait 1 . Complex functional structures are packed in close proximity and subjected to immense physical forces 1 . This dynamic medium should enable the early detection of a tumor as a space occupying lesion quickly becomes symptomatic 2 .…”

Section: Introductionmentioning

confidence: 99%

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Malignant neoplasms originating from the bones of the foot: Predilection of hematological malignancies and sex‐related and ethnic disparities in amputation

Jawad

Farhan

Haffner

et al. 2021

Journal of Surgical Oncology

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Purpose: Neoplasms originating from the "small bones of the lower limb and the overlapping joints" are rare but portend a serious prognosis. Current study utilizes a population-based registry in the United States to characterize the malignancies of the foot. Methods: National Cancer Institute's Surveillance, Epidemiology and End Result database from 1975 to 2017 was queried to report incidence and survival data in 514 patients in the Uited States. Kaplan-Meier and Cox Regression were used to determine the prognostic factors affecting survival. Chi square test was used to assess the correlation.Results: Hematological malignancies constituted 14.8% of the entire cohort. Incidence of the foot neoplasms was 0.024 per 100 000 persons in 2017 and has not significantly changed since 1975 (p > 0.05). Disease-specific-5-year survival for the entire cohort was 73%. On multivariate analysis younger age groups, "localized" stage and extent of surgical resection were predictors of improved outcomes. A significant correlation was found between amputation with male sex and Hispanic ethnicity. Conclusions:The current study analyzes data from population-based registry reporting incidence and survival data for patients with neoplasms of the foot. Independent prognostic factors include age, stage and extent of surgical resection.

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Section: Resultsmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Malignant neoplasms originating from the bones of the foot: Predilection of hematological malignancies and sex‐related and ethnic disparities in amputation

Jawad

Farhan

Haffner

et al. 2021

Journal of Surgical Oncology

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“…Tumours of the foot and ankle account for 4-5% of all musculoskeletal tumours [52]. The majority of the soft tissue tumours of the foot and ankle are uncommon and benign [37,43].…”

Section: Discussionmentioning

confidence: 99%

Surgical excision of complex lipoma from the foot: a case report 

Uddin

Flanagan

Reilly

2020

Preprint

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Background: Soft tissue malignant tumours of the foot and ankle are rare. Diagnostic imaging and interventional biopsy are vital to establish the nature and grading of a suspicious tumour prior to surgical intervention. The purpose of the study is to provide an account on how a symptomatic mass to the plantar aspect of the foot warranted a referral to a sarcoma centre, highlighting the importance of having urgent access to diagnostic imaging and a pathway to refer suspected cases to specialist centres. Method: A single patient with a symptomatic soft tissue tumour of the plantar foot was referred from our service to the regional sarcoma centre. It was considered to be benign and therefore open surgical resection was performed under local anaesthesia by our team, and the lesion sent for histopathological examination. Results: Histopathological analysis identified the excised mass as a lipoma to show no atypia or necrosis and mature adipose tissue with fibrous bands. At 2 years postoperatively there was no recurrence and the patient presented an asymptomatic foot. Favourable patient reported outcomes measures were observed. Conclusion: United Kingdom (UK) Guidelines suggest that all soft tissue masses of suspicious nature, greater than 50mm, deep seated irrespective of size, or fast growing should be referred to a sarcoma unit prior to surgical management. European guidance identifies a threshold of 15mm for a mass in the foot. Patients presenting with red flag symptoms irrespective of size of mass should be referred to a sarcoma centre. Advanced imaging and multidisciplinary input to enable appropriate surgical planning is recommended for these soft tissue tumours that present to the foot and ankle surgeon. Level of evidence: V case study.

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“…Estrogen deficiency reduces bone mineral density, making the bone more fragile. If bone defects are of critical size or patients have an impaired bone healing due to metabolic or inflammatory diseases such as diabetes mellitus and osteoporosis, the defects will not heal completely without additional surgical intervention [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

et al. 2020

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Bone defects of critical size after compound fractures, infections, or tumor resections are a challenge in treatment. Particularly, this applies to bone defects in patients with impaired bone healing due to frequently occurring metabolic diseases (above all diabetes mellitus and osteoporosis), chronic inflammation, and cancer. Adjuvant therapeutic agents such as recombinant growth factors, lipid mediators, antibiotics, antiphlogistics, and proangiogenics as well as other promising anti-resorptive and anabolic molecules contribute to improving bone healing in these disorders, especially when they are released in a targeted and controlled manner during crucial bone healing phases. In this regard, the development of smart biocompatible and biostable polymers such as implant coatings, scaffolds, or particle-based materials for drug release is crucial. Innovative chemical, physico- and biochemical approaches for controlled tailor-made degradation or the stimulus-responsive release of substances from these materials, and more, are advantageous. In this review, we discuss current developments, progress, but also pitfalls and setbacks of such approaches in supporting or controlling bone healing. The focus is on the critical evaluation of recent preclinical studies investigating different carrier systems, dual- or co-delivery systems as well as triggered- or targeted delivery systems for release of a panoply of drugs.

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Malignant tumours of the foot and ankle

Cited by 30 publications

References 59 publications

Malignant neoplasms originating from the bones of the foot: Predilection of hematological malignancies and sex‐related and ethnic disparities in amputation

Malignant neoplasms originating from the bones of the foot: Predilection of hematological malignancies and sex‐related and ethnic disparities in amputation

Surgical excision of complex lipoma from the foot: a case report

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

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Malignant tumours of the foot and ankle

Cited by 30 publications

References 59 publications

Malignant neoplasms originating from the bones of the foot: Predilection of hematological malignancies and sex‐related and ethnic disparities in amputation

Malignant neoplasms originating from the bones of the foot: Predilection of hematological malignancies and sex‐related and ethnic disparities in amputation

Surgical excision of complex lipoma from the foot: a case report&nbsp;

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

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Surgical excision of complex lipoma from the foot: a case report