“…BARTH (1956) found that there was more skin injury after combined heat and irradiation than with irradiation alone, findings which were at variance with the results of BIRKNER & WACHS-ROHDENBURG & PRIME ( 1921 \ using the Crocker 180 tumour in mice and spontaneous mammary tumours of the Lathrop mouse strain, and HILL (1934) using a Jensen sarcoma and an unidentified mouse tumour, all found regression of the malignant growth when subjected to heat plus a sub-lethal dose of irradiation. ROHDENBURG & PRIME found no significant difference when either heat or radiation therapy was given first in combination therapy; while ARONS & SOKOLOFF FUCHS ( 1935) reported that simultaneous therapy or the application of heat immediately subsequent to irradiation gave the best results. JARES & WARREN (1937) found that a time interval of twelve to twenty-four hours between heat and irradiation reduced the beneficial effects of the combined therapy.…”