The rapid pace of economic exploration of the Arctic against the backdrop of progressing environmental change put a high priority on improving understanding of health impacts in the northern communities. Deficiencies in the capability to capture the complexity of health-influencing parameters along with a lack of observations in circumpolar territories present major challenges to establishing credible projections of disease incidence across varying northern environments. It is thus crucial to reveal the relative contributions of coacting factors to provide a basis for sustainable solutions in the sphere of public health. In order to better understand the adverse effects associated with public health, this study employed six-stage multiple regression analysis of incidence rates of fourteen diseases (International Classification of Diseases (ICD-11) codes most widespread in the Russian Arctic) against a set of environmental, nutritional, and economic variables. Variance inflationary factor and best-subsets regression methods were used to eliminate collinearity between the parameters of regression models. To address the diversity of health impacts across northern environments, territories of the Arctic zone of Russia were categorized as (1) industrial sites, (2) urban agglomerations, (3) rural inland, and (4) coastline territories. It was suggested that, in Type 1 territories, public health parameters were most negatively affected by air and water pollution, in Type 2 territories—by low-nutrient diets, in Type 3 and Type 4 territories—by economic factors. It was found that in the Western parts of the Russian Arctic, poor quality of running water along with low access to the quality-assured sources of water might increase the exposure to infectious and parasitic diseases and diseases of the circulatory, respiratory, and genitourinary systems. Low living standards across the Russian Arctic challenged the economic accessibility of adequate diets. In the cities, the nutritional transition to low-quality cheap market food correlated with a higher incidence of digestive system disorders, immune diseases, and neoplasms. In indigenous communities, the prevalence of low diversified diets based on traditional food correlated with the increase in the incidence rates of nutritional and metabolic diseases.