Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease

Dávalos-Yerovi, Vanesa; Marco, Ester; Sánchez-Rodríguez, Dolores; Duran, Xavier; Meza-Valderrama, Delky; Rodríguez, Diego A.; Muñoz, Elena; Tejero-Sánchez, Marta; Muns, María Dolors; Guillén-Solà, Anna; Duarte, Esther

doi:10.3390/nu13020369

Cited by 37 publications

(53 citation statements)

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“…10 Malnutrition according to GLIM criteria was associated with mortality, survival prediction, and clinical outcomes in patients with cancer, chronic obstructive pulmonary disease, and heart failure. [11][12][13][14] Several studies have shown positive results using phase angle (PhA) as a nutrition and prognostic marker for malnutrition. 15,16 PhA is a raw indicator of the cell membrane integrity and functionality.…”

Section: Introductionmentioning

confidence: 99%

Phase angle as predictor of malnutrition in people living with HIV/AIDS

et al. 2021

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Background: Phase angle (PhA), measured by bioelectrical impedance analysis (BIA) has been studied as an indicator of survival in people living with HIV (PLWH). However, it remains unclear whether PhA is associated with malnutrition or low CD4+ T-cell counts.Objective: In this study, we assessed the discriminative capacity of PhA for malnutrition detection using Global Leadership Initiative on Malnutrition (GLIM) criteria in PLWH, aiming to propose cutoff points for this population.Methods: This retrospective observational study included 427 adult PLWH (13% female). Participants were classified according to malnutrition status by using GLIM criteria. Body composition was assessed by using BIA. CD4+ T-cell counts were determined by flow cytometry.Results: According to GLIM criteria, 30% of the participants were malnourished. Multivariate regression analysis showed that PhA (adjusted odds ratio [OR], 0.10; 95% CI, 0.05-0.18; P < 0.001), fat-mass percentage (adjusted OR, 0.86; 95% CI, 0.82-0.90; P < 0.001), and male sex (adjusted OR, 0.26; 95% CI, 0.09-0.76; P = 0.013) were independently associated with malnutrition. A PhA cutoff of 5.45 • in men and 4.95 • in women may predict malnutrition with sensitivity and specificity >70%. Conclusion:PhA could be a valid, useful, and simple predictor of malnutrition in PLWH.

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Section: Introductionmentioning

confidence: 99%

Phase angle as predictor of malnutrition in people living with HIV/AIDS

et al. 2021

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“…Both malnutrition and sarcopenia are common in patients with COPD. Malnutrition may affect about 50% of elderly individuals with COPD [ 17 ], and sarcopenia may be present in one in four to one out of seven patients, particularly those with severe and very severe obstruction [ 18 , 19 , 20 , 21 ]. Catabolic processes are intensified both in COPD and aging, leading to the reduction of muscle mass.…”

Section: Discussionmentioning

confidence: 99%

“…We found four studies assessing the prevalence of sarcopenia diagnosed based on the EWGSOP2 criteria in patients with COPD, including two papers concerning elderly subjects [ 18 , 19 , 20 , 21 ].Tsekoura et al [ 18 ] analyzed a group of 69 elderly patients with COPD (mean age 71.33 ± 7.48 years). They diagnosed sarcopenia in 17 participants (24.6%).…”

Section: Discussionmentioning

confidence: 99%

“…They diagnosed sarcopenia in 17 participants (24.6%). Marco et al [ 19 ] studied 79 community-dwelling COPD rehabilitation patients (mean age 67.5 ± 7.1 years). They found sarcopenia in 10 persons (12.7%), which is very similar to the prevalence of sarcopenia in our study population (12.9%).…”

Section: Discussionmentioning

confidence: 99%

“…While it is true that the prevalence of sarcopenia or malnutrition in subjects with COPD has been investigated in many studies, there are only a few reports in which the most recent diagnostic criteria (GLIM and EWGSOP2) were applied [ 19 , 20 , 21 , 22 , 23 ]; none of the studies involved both conditions. The present analysis aimed to assess the prevalence of malnutrition, sarcopenia, and malnutrition-sarcopenia syndrome in elderly subjects with COPD and investigate the relationship between COPD severity and these conditions.…”

Section: Introductionmentioning

confidence: 99%

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Malnutrition, Sarcopenia, and Malnutrition-Sarcopenia Syndrome in Older Adults with COPD

Kaluźniak-Szymanowska

Krzymińska‐Siemaszko

Deskur-Śmielecka

et al. 2021

Nutrients

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Purpose: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the world population. In addition to airflow obstruction, COPD is associated with multiple systemic manifestations, including impaired nutritional status or malnutrition and changes in body composition (low muscle mass, LMM). Poor nutritional status and sarcopenia in subjects with COPD leads to a worse prognosis and increases health-related costs. Data from previous studies indicate that 30–60% of subjects with COPD are malnourished, 20–40% have low muscle mass, and 15–21.6% have sarcopenia. This study aimed to assess the prevalence of malnutrition, sarcopenia, and malnutrition-sarcopenia syndrome in elderly subjects with COPD and investigate the relationship between COPD severity and these conditions.Patients and methods: A cross-sectional study involving 124 patients with stable COPD, aged ≥60, participating in a stationary pulmonary rehabilitation program. Nutritional status was assessed following the Global Leadership Initiative on Malnutrition (GLIM) criteria and sarcopenia with the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. The results of pulmonary function tests and exercise capacity were obtained from the hospital database. Results: 22.6% of participants had malnutrition according to the GLIM criteria. Subjects with malnutrition had lower gait speed (p = 0.0112) and worse results of the Six Minute Walk Test. Sixteen participants (12.9%) had sarcopenia; 12 subjects with sarcopenia had concomitant malnutrition. The prevalence of severe and very severe obstruction (GOLD3/GOLD4) was 91.7%. It was significantly higher in patients with malnutrition-sarcopenia syndrome. Conclusions: Malnutrition was found in nearly one out of four subjects with COPD, while sarcopenia was one out of seven patients. About 10% of our study sample had malnutrition-sarcopenia syndrome. The prevalence of severe and very severe obstruction was significantly higher in patients with malnutrition-sarcopenia syndrome.

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Undernutrition is associated with mortality, exacerbation, and poorer quality of life in patients with chronic obstructive pulmonary disease: A systematic review with meta‐analysis of observational studies

Pereira

Lima

Silva

2022

J Parenter Enteral Nutr

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Impaired nutrition status is recognized as a risk factor for worse clinical outcomes in patients with chronic obstructive pulmonary disease (COPD). The aims of this study were to investigate how undernutrition is diagnosed, its prevalence, and whether there is an association between this condition and clinical outcomes in patients with COPD.The search for this systematic review of observational studies (PROSPERO: CRD42020191888) was performed in the PubMed, Embase, and Scopus databases, with no date or language restrictions. The studies had to report data on the diagnosis of undernutrition and its association with mortality, exacerbation, length of hospital stay, or quality of life in adult patients with COPD. A meta-analysis with a random-effects model was performed to combine data. Forty-nine studies were included (20 of them classified as having a low risk of bias), and the most common diagnostic method of undernutrition was body mass index (BMI) (n = 36). The pooled prevalence of undernutrition was equal to 20% (95% CI, 0.15-0.25; I² = 100%), and it was associated with mortality (risk ratio = 1.97; 95% CI, 1.55-2.50; I² = 98%), exacerbation (risk ratio = 1.73; 95% CI, 1.03-2.91; I² = 96%), and poorer quality of life (mean difference = 8.25; 95% CI,; I² = 79%). For all outcomes, the certainty of evidence was very low.In conclusion, undernutrition is prevalent and is associated with poorer outcomes in patients with COPD. However, undernutrition is mainly diagnosed by BMI, which underreports its prevalence, and the certainty of the evidence is very low.

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Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease

Cited by 37 publications

References 37 publications

Phase angle as predictor of malnutrition in people living with HIV/AIDS

Phase angle as predictor of malnutrition in people living with HIV/AIDS

Malnutrition, Sarcopenia, and Malnutrition-Sarcopenia Syndrome in Older Adults with COPD

Undernutrition is associated with mortality, exacerbation, and poorer quality of life in patients with chronic obstructive pulmonary disease: A systematic review with meta‐analysis of observational studies

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