Malnutrition and Associated Motor and Non-motor Factors in People with Parkinson's Disease

Abstract

Background: People with Parkinson's disease (PwP) are at higher risk of developing malnutrition. Several factors have been suggested to be involved including motor symptoms, non-motor symptoms, and treatment-related complications. Objective: The objective of the study was to analyze the combined effect of motor, non-motor, and pharmacological factors in the risk of malnutrition in PwP. Methods: Eighty-seven consecutive PwP were included in the study. Clinical data and pharmacological treatment were collected. Nutritional status was assessed using the Mini-Nutritional Assessment (MNA) questionnaire. Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Non-motor Symptoms Scale (NMSS), Hamilton Depression Rating Scale HAM-D, and Montreal Cognitive Assessment were applied. Results: Thirty (34.4%) PwP were at risk of malnutrition and seven had malnutrition (8%). Abnormal nutritional status was associated with lower education, higher MDS-UPDRS Parts I, II, and III and total scores, and higher scores in the NMSS domain of sleep disorders and fatigue. MDS-UPDRS motor score remained as a determinant of abnormal nutritional status, defined as MNA <23.5, with an odds ratio 1.1 (95% confidence interval 1.01-1.10, p = 0.02). Conclusion: The main factor associated with nutritional status was severity of the motor symptoms as assessed by the MDS-UPDRS Part III. Non-motor symptoms and treatment-related complications were not associated with malnutrition. (REV INVEST CLIN. [ahead of print])

Impact of Parkinson's disease treatment on fluctuations in weight

“…However, the rate of WL in the present study (− 1.54% [IQR, − 3.32-1.06]) was lower in comparison to previous studies (3-5%) [19], and stable BMI (25.1 kg/m2 [IQR, 19.2-25.0]), may be in uenced by the fact that study population was in better condition in comparison to patients who were placed under the control of expert neurologists. PD patients are reported to be at risk of malnutrition [20][21][22][23][24]. However, in this study, most participants who received DBS and LCIG therapies were regularly admitted to our hospital for scheduled neurological examinations after surgery and could be well-managed in a state of normal nutrition or mild malnutrition.…”

Prevalence of Malnutrition in Patients with Parkinson’s Disease: A Systematic Review

“…Mini Nutritional Assessment is used for assessing the nutritional status of patients. There were 22 studies included in which MNA assessments were conducted [ 10 , 11 , 12 , 16 , 17 , 18 , 19 , 21 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. There was a total of 2713 participants, of which 39.2% were female and 60.8% were male.…”

“…We took into consideration 49 studies [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ] in which BMI was assessed, resulting in 5727 patients, 57.3% of whom were men and 40.9% of whom were women. The lowest reported mean BMI was 17.84 kg/m 2 [ ...…”

“… Quality assessment of cross-sectional studies [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. …”

The Role of Diet and Dietary Patterns in Parkinson’s Disease

“…For instance, a three-year cohort study found a direct relationship between constipation and body fat loss [ 39 ]. Additionally, researchers observed a direct relationship between an individual’s risk of malnutrition and motor symptom severity [ 40 , 41 ]. Other nutrition-related symptoms may include dementia, depression, dyskinesia, dysphagia, gastroparesis, hyposmia, tremors, rigidity, and small bowel dysfunction [ 38 , 42 , 43 , 44 , 45 ].…”