Malnutrition and overall survival in older patients with cancer.

Zhang, Xiaotao; Sun, Ming; Geng, Yunlong; Dinney, Colin P.N.; Popat, Uday; Champlin, Richard E.; Valero, Vicente; Tripathy, Debu; Hedberg, Ann-Marie; Stroehlein, John R.; Edwards, Beatrice J.

doi:10.1200/jco.2018.36.15_suppl.e22015

Cited by 7 publications

(10 citation statements)

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“…Frailty, sarcopenia, and functional impairment are important risk factors for malnutrition in elderly patients with cancer (29). Elderly malnourished patients with cancer have a higher risk of death and prolonged LOS (13,28,30).…”

Section: Discussionmentioning

confidence: 99%

“…Second, malnutrition affects the function and recovery of every organ system (34). Third, malnutrition may lead to some adverse events, such as weakened immune response, reduced tolerance to chemotherapy/immunotherapy, negative treatment outcomes, increased infection rates, increased risk of postoperative complications, and thus reduced quality of life (13,32,(35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

“…The GLIM criteria are based on expert opinion and require validation and reliability testing in different populations (11,12). Currently, limited studies use the GLIM criteria to assess malnutrition in patients with cancer, and the methods are not uniform; some studies aimed to develop nomograms or scoring systems in combination with GLIM criteria to predict cancer survival (13,14). Meanwhile, other studies have been performed in more specific cancer sites and populations, such as for esophageal tumors (15), hematological tumors (16), and outpatient with cancer (17).…”

Section: Introductionmentioning

confidence: 99%

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Influence of Malnutrition According to the GLIM Criteria on the Clinical Outcomes of Hospitalized Patients With Cancer

Liu

et al. 2021

Front. Nutr.

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Background: Malnutrition is prevalent among patients with cancer. The Global Leadership Initiative on Malnutrition (GLIM) released new universal criteria for diagnosing malnutrition in 2019. The objectives of this study were to assess the prevalence of malnutrition in patients with cancer using the GLIM criteria, explore the correlation between the GLIM criteria, and clinical outcomes, and compare the GLIM criteria with subjective global assessment (SGA).Methods: This retrospective analysis was conducted on 2,388 patients with cancer enrolled in a multicenter study. Nutritional risk was screened using the Nutritional Risk Screening-2002, and the nutritional status was assessed using SGA and GLIM criteria. Chi-square analysis and Wilcoxon rank sum test, stratified by age 65 years, were used to evaluate the effect of GLIM-defined malnutrition on clinical outcomes. Logistic regression analysis was used to analyze the nutritional status and complications, and the interrater reliability was measured using a kappa test.Results: The prevalence of malnutrition defined by the GLIM criteria was 38.9% (929/2,388). GLIM-defined malnutrition was significantly associated with in-hospital mortality (P = 0.001) and length of hospital stays (P = 0.001). Multivariate logistic regression analysis showed GLIM-defined malnutrition significantly increased complications (odds ratio [OR] 1.716, 95% CI 1.227–2.400, P = 0.002). The GLIM criteria had a “moderate agreement” (kappa = 0.426) compared with the SGA.Conclusions: The prevalence of malnutrition in hospitalized patients with cancer is high, and malnourishment in patients with cancer is associated with poorer clinical outcomes. The use of the GLIM criteria in assessing the nutritional status of inpatients with cancer is recommended and can be used as the basis for nutritional interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of Malnutrition According to the GLIM Criteria on the Clinical Outcomes of Hospitalized Patients With Cancer

Liu

et al. 2021

Front. Nutr.

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“…Most of the research done within the field of geriatric oncology has highlighted differences in tumour-extrinsic features between older and young age groups and their impact on treatment effectiveness and outcome. Hostspecific factors such as functional disability, 7 polypharmacy, [8][9][10][11] malnutrition, [12][13][14] sarcopenia, [15][16][17][18][19][20][21] cognitive impairment, [22][23][24][25][26] age-related pharmacological differences in the metabolism of anticancer drugs, [27][28][29] systemic metabolic changes, 30 depression, 31,32 and chemotherapy dose adaptation 33,34 have all been reported to affect the disease course in older individuals. In addition, ageism (ie, discrimination based on perceived or actual chronological age) is an invisible and insidious social occurrence that exists in many dimensions within cancer care.…”

Section: Introductionmentioning

confidence: 99%

Is cancer biology different in older patients?

Herck

Feyaerts

Alibhai

et al. 2021

The Lancet Healthy Longevity

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Roughly 50% of cancer cases occur in people aged 65 years or older. Older people are often diagnosed at a later stage and might receive less (intensive) treatment, which might affect the outcome. In addition, an older age might be associated with biological differences in tumour and microenvironment behaviour, a domain that has been poorly studied so far. In this narrative Review of published literature, we explored the reported differences in tumour biology according to age in five major cancer types: breast, colorectal, prostate, lung, and melanoma. Our literature search uncovered clear differences in tumour histology and subtype distribution in older people compared with younger patients, as well as age-specific patterns of tumour mutations and other molecular alterations. Several studies also indicate notable changes in tumour-infiltrating immune cells in tumours of older versus younger people, although this research is still in its infancy. More research is needed and might lead to a better understanding of the biology of ageing in relation to malignancy. This knowledge could provide new perspectives for more personalised cancer treatments, eventually improving the global outcomes of older patients with cancer.

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“…Weight loss is a common manifestation of malnutrition and has been recognized to have adverse effects on chemotherapy and survival (9,14,15). In this study, we observed an average weight-loss of 4.28% after induction chemotherapy.…”

Section: Discussionmentioning

confidence: 51%

Changes in body composition of patients with acute leukemia during induction and consolidation chemotherapies

Zou

et al. 2022

Preprint

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Purpose: Malnutrition is detrimental to the treatment and prognosis of patients with acute leukemia (AL). Body composition analysis is a reliable method to monitor and assess the nutritional status of patients. However, there are few studies focusing on body composition changes of patients with AL undergoing chemotherapy.Methods: Patients who were newly-diagnosed with AL were enrolled in this study. The body composition was measured before and after induction and consolidation chemotherapies. Paired-samples T test and multiple linear regression analysis were used to compare body composition changes and explore the influencing factors.Results: After induction chemotherapy, weight, body mass index (BMI), total body water, fat free mass (FFM), skeletal muscle mass (SMM) and basal metabolic rate were significantly decreased, but fat mass (FM), percentage of body fat (PBF) and visceral fat area (VFA) were significantly increased. There were no significant changes in body composition during consolidation chemotherapy. Multivariate analysis showed that age was negatively related to declines in weight, BMI, FFM and SMM during induction chemotherapy and acute myelocytic leukemia patients dropped less in FFM and SMM and increased less in PBF and VFA, compared with acute lymphocytic leukemia (ALL).Conclusion: Decreased FFM and increased FM were seen in AL patients after induction chemotherapy. Conventional nutritional monitoring and timely support are very important for patients with AL during chemotherapy, especially for ALL patients.

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Malnutrition and overall survival in older patients with cancer.

Cited by 7 publications

References 0 publications

Influence of Malnutrition According to the GLIM Criteria on the Clinical Outcomes of Hospitalized Patients With Cancer

Influence of Malnutrition According to the GLIM Criteria on the Clinical Outcomes of Hospitalized Patients With Cancer

Is cancer biology different in older patients?

Changes in body composition of patients with acute leukemia during induction and consolidation chemotherapies

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