Malnutrition as a predictor of poor postoperative outcomes in gynecologic cancer patients

Kathiresan, A.S.Q.; Brookfield, Kathleen; Schuman, S.; Lucci, Joseph A.

doi:10.1007/s00404-010-1659-y

Cited by 63 publications

(38 citation statements)

References 14 publications

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“…Another one was excluded as it did not study the clinical outcomes according to the body mass index (BMI) categories (8).…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, however, little is known regarding the impact of underweight status (which is a common cause of malnutrition) on ovarian cancer prognosis. It is well known that malnutrition frequently coexists with gynecologic malignancies (8). Furthermore, it seems that the nutritional status of patients significantly affects both the patients' survival and overall quality of life (9).…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Underweight Status on the Prognosis of Ovarian Cancer Patients: A Meta-Analysis

Pergialiotis

Doumouchtsis

Perrea

et al. 2016

Nutrition and Cancer

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Malnutrition and underweight status pose an unfavorable prognosis for cancer patients. Several studies have addressed the impact of a low body mass index (BMI) (<18.5 kg/m(2)) on ovarian cancer progression. However, their results seem to be conflicting. The present meta-analysis investigates whether the underweight status negatively affects the progress of ovarian cancer. We conducted a systematic review searching the Medline (1966-2014), Scopus (2004-2014), Popline (1974-2014), ClinicalTrials.gov (2008-2014), and Cochrane Central Register of Controlled Trials (CENTRAL) (1999-2014) databases together with reference lists from included studies. All prospective and retrospective observational cohort studies were included. Statistical meta-analysis was performed using the RevMan 5.1 software. Current evidence suggests that the stage of the disease does not differ between underweight and normal-weight patients [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.46-1.39 for stage I; OR 1.27, 95% CI 0.71-2.27 for stage II; OR 1.03, 95% CI 0.71-1.51 for stage III; and OR 1.05, 95% CI 0.63-1.76 for stage IV disease]. Concurrently, the risk of residual disease after surgery (OR 1.03, 95% CI 0.69-1.52) and the risk of dying due to ovarian cancer (OR 1.08, 95% CI 0.64-1.85) seem to be similar. According to the findings of our systematic review, the underweight status does not seem to have a detrimental impact on ovarian cancer prognosis. However, the methodological limitations of published studies and the small number of enrolled underweight patients preclude firm results. Thus, future research in this field is necessary.

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“…Another one was excluded as it did not study the clinical outcomes according to the body mass index (BMI) categories (8).…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Impact of Underweight Status on the Prognosis of Ovarian Cancer Patients: A Meta-Analysis

Pergialiotis

Doumouchtsis

Perrea

et al. 2016

Nutrition and Cancer

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“…Preoperative hypoalbuminemia, usually defined as values < 3.5 g/dL, has been associated with increased morbidity and mortality following general surgery, 6-8 kidney transplantation, 9 vascular surgery, 10 radical cystectomy for bladder cancer, 11,12 gynecologic oncology procedures, 13,14 and pathologic orthopaedic fractures related to metastatic bone disease. 15 Furthermore, there is a large body of literature on nutritional status and hip fractures in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Nutritional Status as an Adjunct Predictor of Major Postoperative Complications Following Anterior Cervical Discectomy and Fusion

Buerba

Grauer

2016

Clinical Spine Surgery: A Spine Publication

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“…In general, this traditional thinking appears to be true for underweight patients. However, in the case of BMI >30, a notable number of postoperative complications occur [8]. Our own group at the University of Virginia (UVA) also found similar poor 30 day outcomes in a group of elderly patients who were obese [10].…”

Section: Body Mass Indexmentioning

confidence: 65%

“…This appeared to be true regardless of cancer type. Patients with albumin below the normal range were 3.44 times more likely to develop a postoperative complication [8].…”

Section: Measures Of Preoperative Nutritional Statusmentioning

confidence: 99%

Nutrition in Gynecologic Cancer

Cantrell

Saks

Grajales

et al. 2015

Curr Obstet Gynecol Rep

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Nutrition plays a role in every aspect of gynecologic cancer care from diagnosis to death. Unfortunately, the topic is not well researched in gynecology oncology and much that is known about nutrition comes from other disciplines. Nutrition and resultant body mass index (BMI) affects a patient's risk of diagnosis of a gynecologic malignancy, treatment tolerance, complications, and survival. Sadly, 20 % of patients with cancer die of malnutrition rather than their disease. However, not all malnourished patients are thin, as patients with BMIs in the obese range often do not have adequate nutrition. Recent literature challenges previous thoughts about feeding before and after surgery and clearly links obesity and diet quality with survival. More research is needed on the nutrition of patients with gynecologic malignancy, specifically how diet quality interfaces with the tolerance of radiation and chemotherapy.

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Malnutrition as a predictor of poor postoperative outcomes in gynecologic cancer patients

Cited by 63 publications

References 14 publications

The Impact of Underweight Status on the Prognosis of Ovarian Cancer Patients: A Meta-Analysis

The Impact of Underweight Status on the Prognosis of Ovarian Cancer Patients: A Meta-Analysis

Preoperative Nutritional Status as an Adjunct Predictor of Major Postoperative Complications Following Anterior Cervical Discectomy and Fusion

Nutrition in Gynecologic Cancer

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