Malnutrition by GLIM criteria in chronic pancreatitis: Prevalence, predictors, and its impact on quality of life

Gopi, Srikanth; Qamar, Sumaira; Singh, Namrata; Agarwal, Samagra; Yegurla, Jatin; Rana, Atul; Gunjan, Deepak; Sharma, Sanchit

doi:10.1016/j.pan.2022.02.004

Cited by 12 publications

(7 citation statements)

References 25 publications

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“…Previous studies have shown that almost half of CP patients suffer from malnutrition according to the Global Leadership Initiative on Malnutrition criteria. 8 In spite of its high prevalence of malnutrition, there is still a lack of gold standard in screening and evaluating the nutritional status of CP patients. In previous studies, only body weight and biochemical blood parameters were used to evaluate CP patients’ nutritional status.…”

Section: Nutritional Supportmentioning

confidence: 99%

Management of chronic pancreatitis: recent advances and future prospects

Han,

Lv,

2024

Therap Adv Gastroenterol

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As a progressive fibroinflammatory disease, chronic pancreatitis (CP) often manifests as recurrent bouts of abdominal pain with or without complications, causing a heavy burden of health care. In recent years, some meaningful insights into the management of CP have been obtained from randomized controlled trials, systematic reviews, and meta-analyses, which were of great importance. Based on this research, it is shown that there are various treatments for CP. Therefore, it is of great importance to choose a suitable strategy for patients with CP individually. Relevant evidence on the management of CP was summarized in this review, including nutrition supplements, medication, endoscopy, surgery, exploration of novel therapies as well as evaluation and prediction of treatment response.

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Section: Nutritional Supportmentioning

confidence: 99%

Management of chronic pancreatitis: recent advances and future prospects

Han,

Lv,

2024

Therap Adv Gastroenterol

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“…Якість життя хворих на ХП У ретроспективному дослідженні, проведеному для оцінки поширеності мальнутриції у хворих на ХП відповідно до критеріїв Глобальної ініціативи лідерів з мальнутриції (GLIM), додатково аналізували якість життя пацієнтів (n=287) [16]. Мальнутриція вияви лася асоційованою зі зниженням якості життя (50,0 vs 66,7; р<0,001), дефіцитом енергії (50,0 vs 58,3; р=0,003) порівняно з контролем.…”

Section: хп і нервова системаunclassified

Consequences of chronic pancreatitis and exocrine pancreatic insufficiency, or When leaves fall from trees

Gubergrits,

Byelyayeva,

Mozhyna

2023

Bul. of the Club of Pancr.

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Aim. To analyze current literature data on the complications of chronic pancreatitis (CP) with exocrine pancreatic insufficiency (EPI). Main statements. According to statistical evidence, the presence of CP is associated with an increased risk of death, while the concomitant EPI significantly increases the risk of death. EPI is a big independent risk factor for death in patients with CP, which emphasizes the need for adequate correction of EPI in order to reduce mortality in this group. EPI is associated not only with an increase in mortality in CP patients but also with the development of various trophological defects. It has been stated that CP course is accompanied by a decrease in the level of albumin, malabsorption of fat-soluble vitamins (A, E, and D), carotenoids (beta-carotene, lycopene, cryptotaxin, and zeaxanthin), and the development of osteopenia and osteoporosis. CP course is linked to anxiety, depression, tumor pathology (pancreatic ductal adenocarcinoma, esophageal cancer, and stomach cancer), damage to the cardiovascular system, an increase in cardiovascular risk, and a high chance of myocardial infarction, stroke, and pancreatitis-induced thrombosis of the splenic vein. Modern enzyme replacement therapy makes it possible to compensate for some of the consequences of chronic EPI, reduce numerous signs of malnutrition, normalize the body mass index, and improve the quality of life of CP patients with EPI.

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“…Symptoms may encompass abdominal pain, diarrhea, and/or greasy stools, leading to nutrition deficits and reduced quality of life. 3 Etiologic contributors to CP include heavy alcohol and tobacco use, autoimmune processes, hyperlipidemia, and hereditary factors, although cases may also be idiopathic. 1,2 Nutrition impairment in CP may be driven by several factors, such as poor dietary intake due to abdominal pain, excessive alcohol use, inflammatory-induced changes to skeletal muscle and bone metabolism, altered blood glucose control, and inadequate macronutrient and micronutrient absorption from exocrine pancreatic insufficiency (EPI).…”

Section: Introductionmentioning

confidence: 99%

“…Chronic pancreatitis (CP), characterized by progressive inflammation, calcification, and scarring to the pancreatic tissue, 1,2 is associated with significant gastrointestinal effects. Symptoms may encompass abdominal pain, diarrhea, and/or greasy stools, leading to nutrition deficits and reduced quality of life 3 . Etiologic contributors to CP include heavy alcohol and tobacco use, autoimmune processes, hyperlipidemia, and hereditary factors, although cases may also be idiopathic 1,2 …”

Section: Introductionmentioning

confidence: 99%

Fat‐soluble vitamin deficiency and exocrine pancreatic insufficiency among adults with chronic pancreatitis: Is routine monitoring necessary for all patients?

Estes‐Doetsch,

Roberts,

Newkirk

et al. 2023

Nut in Clin Prac

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Chronic pancreatitis (CP) is often associated with exocrine pancreatic insufficiency (EPI), which may increase risk for fat‐soluble vitamin depletion. Although vitamin D deficiency is widespread among the general population, vitamins A, E, and K deficiencies may more uniquely present in patients with CP. Yet, it is unclear whether fat‐soluble vitamin status should be routinely monitored in all patients with CP or limited to those with EPI. The purpose of this review is to describe the laboratory status of vitamins A, E, and K in adult patients with CP and their association with exocrine pancreatic function. Five primary, observational studies met the inclusion criteria for qualitative synthesis. Biochemical deficiencies in fat‐soluble vitamins were observed across trials but results varied with respect to whether EPI increased risk. Challenges related to the diagnosis and treatment of EPI along with potential confounders may contribute to the heterogeneity among study results. Although more studies are needed to determine the influence of pancreatic enzyme replacement therapy on fat‐soluble vitamin status as well as effective vitamin repletion strategies, clinicians should consider periodically screening for deficiencies in all patients with CP regardless of EPI to avoid associated health effects of vitamin depletion.

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Malnutrition by GLIM criteria in chronic pancreatitis: Prevalence, predictors, and its impact on quality of life

Cited by 12 publications

References 25 publications

Management of chronic pancreatitis: recent advances and future prospects

Management of chronic pancreatitis: recent advances and future prospects

Consequences of chronic pancreatitis and exocrine pancreatic insufficiency, or When leaves fall from trees

Fat‐soluble vitamin deficiency and exocrine pancreatic insufficiency among adults with chronic pancreatitis: Is routine monitoring necessary for all patients?

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