Malnutrition in Older Adults with Cancer

Zhang, Xiaotao; Edwards, Beatrice J.

doi:10.1007/s11912-019-0829-8

Cited by 83 publications

(48 citation statements)

References 92 publications

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“…Older adults with cognitive impairment or dementia, bedridden, functionally dependent, severe dysphagia, chronic obstructive pulmonary disorder (COPD), and end-stage illnesses were not included since these patients usually have a pre-existing history of weight loss, decreased body mass index, or deteriorated nutritional status and a higher risk of infections [20][21][22][23][24][25][26].…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Malnutrition and Depression in Older Adults Living in Nursing Homes in Mexico City

et al. 2020

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This study evaluated the association between nutritional status, depressive symptoms, and the number of prescription drugs taken by older adults living in nursing homes in Mexico City. In a cross-sectional study, 262 participants were subjected to anthropometric and nutritional (Mini Nutritional Assessment (MNA)) evaluations; additionally, their depression (Geriatric Depression Scale (GDS)) and functional status were assessed. Multiple logistic regression was used for identifying factors associated with the risk of malnutrition/malnourishment. The mean age of participants was 83.1 ± 8.6 years. A total of 59.9% and 21.1% were at risk of malnutrition and malnourished, respectively. With respect to depression, 27.9% of the participants had mild depression, while 11.4% showed severe depression. An inverse correlation between MNA evaluations and depression scores was found (Spearman’s ρ = −0.4624, p < 0.001); residents with a better nutritional status had lower depression scores. Individuals with depressive symptoms were approximately five times more likely to be at risk of malnutrition or malnourished (OR = 5.82, 95% CI = 2.27–14.89) than individuals without depression. Residents taking three or more prescription drugs daily (OR = 1.83, 95% CI = 1.27–2.63, p < 0.001) were more likely to be at risk of malnutrition or malnourished. In summary, poor nutritional status was associated with depression, while the intake of numerous prescription drugs was associated with being at risk of malnutrition or malnourished.

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Section: Methodsmentioning

confidence: 99%

Prevalence of Malnutrition and Depression in Older Adults Living in Nursing Homes in Mexico City

et al. 2020

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“…All adults with cancer are at risk of malnutrition due to cancer and treatment‐related factors, but older adults are at particularly increased risk. Nearly 66% of older adults with cancer are malnourished, and the cancer diagnosis increases the risk of malnutrition 14‐fold higher 6,7 . Furthermore, the risk of malnutrition is notably even higher for older patients with gastrointestinal (GI) malignancies 8 .…”

Section: Introductionmentioning

confidence: 99%

Association of malnutrition with geriatric assessment impairments and health‐related quality of life among older adults with gastrointestinal malignancies

Williams

Al‐Obaidi

Dai

et al. 2020

Cancer

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Background A majority of older adults with cancer develop malnutrition; however, the implications of malnutrition among this vulnerable population are poorly understood. The goal of this study was to quantify the prevalence of nutrition related‐symptoms and malnutrition among older adults with gastrointestinal (GI) malignancies and the association of malnutrition with geriatric assessment (GA) impairment, health‐related quality of life (HRQoL), and health care utilization. Methods We performed a cross‐sectional study of older adults (≥60 years) who were referred to the GI Oncology clinic at the University of Alabama at Birmingham. Participants underwent the Cancer & Aging Resilience Evaluation survey that includes the abbreviated Patient‐Generated Subjective Global Assessment of nutrition. Nutrition scores were dichotomized into normal (0‐5) and malnourished (≥6), and multivariate analyses adjusted for demographics, cancer type, and cancer stage were used to examine associations with GA impairment, HRQoL, and health care utilization. Results A total of 336 participants were included (men, 56.8%; women, 43.2%), with a mean age of 70 years (standard deviation, ±7.2 years) and colorectal cancer (33.6%) and pancreatic cancer (24.4%) being the most common diagnoses. Overall, 52.1% of participants were identified as malnourished. Malnutrition was associated with a higher prevalence of several GA impairments, including 1 or more falls (adjusted odds ratio [aOR], 2.1), instrumental activities of daily living impairment (aOR, 4.1), and frailty (aOR, 8.2). Malnutrition was also associated with impaired HRQoL domains; both physical (aOR, 8.7) and mental (aOR, 5.0), and prior hospitalizations (aOR, 2.2). Conclusion We found a high prevalence of malnutrition among older adults with GI malignancies that was associated with increased GA impairments, reduced HRQoL, and increased health care utilization.

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“…Notably, the causal relationship between malnutrition and frailty requires clinical researches to make clear. Given the fact that malnutrition is common in older cancer patients, and is mostly caused by tumor invasion, side effects of cancer treatment, cachexia, and anorexia of aging [57]. Hence, there is an urgent need for clinical personnel to early identify malnutrition in cancer patients and then take targeted therapy to improve their nutritional status.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of preoperative frailty in elderly inpatients with gastrointestinal cancer

Zhang

et al. 2020

Preprint

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Background Frailty is emerging as an important determinant for health, while researches in the field of frailty start at a later stage in China and mainly focuses on community elderly dwellers. Little is known about frailty in cancer patients in China, nor the risk factors of frailty. This study aimed to investigate the prevalence of frailty and its risk factors in elderly inpatients with gastrointestinal cancer. Methods This cross-sectional study was performed at a tertiary hospital in China from Mar. 2020 to Nov. 2020. The study enrolled 265 inpatients aged 60 and older with gastrointestinal cancer who successfully underwent surgery. The demographic and clinical characteristics, biochemical laboratory parameters, and anthropometric data were collected from all patients. The Groningen Frailty Indicator was applied to assess patients’ frailty status. Multivariate logistic regression model analysis was carried out to identify risk factors of frailty and estimate their 95% confidence intervals. Results The prevalence of frailty in elderly inpatients with gastrointestinal cancer was 43.8%. A multivariate logistic regression analysis showed that older age (OR = 1.065, 95% CI: 1.001–1.132, P = 0.045), low handgrip strength (OR = 4.346, 95% CI: 1.739–10.863, P = 0.002), no regular exercise habit (OR = 3.228, 95% CI: 1.230–8.469, P = 0.017), and low MNA-SF score (OR = 11.090, 95% CI: 5.119–24.024, P < 0.001) were risk factors of frailty. Conclusions This study suggested that the prevalence of frailty was high among elderly inpatients with gastrointestinal cancer. Older age, low handgrip strength, no regular exercise habit, and low MNA-SF score were risk factors of frailty.

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Malnutrition in Older Adults with Cancer

Cited by 83 publications

References 92 publications

Prevalence of Malnutrition and Depression in Older Adults Living in Nursing Homes in Mexico City

Prevalence of Malnutrition and Depression in Older Adults Living in Nursing Homes in Mexico City

Association of malnutrition with geriatric assessment impairments and health‐related quality of life among older adults with gastrointestinal malignancies

Risk factors of preoperative frailty in elderly inpatients with gastrointestinal cancer

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