Malnutrition is positively associated with cognitive decline in centenarians and oldest-old adults: A cross-sectional study

Feng, Long; Chu, Zhi-xiang; Quan, Xiaojiao; Zhang, Yujie; Yuan, Wei; Yao, Yao; Zhao, Yali; Fu, Shihui

doi:10.1016/j.eclinm.2022.101336

Cited by 31 publications

(17 citation statements)

References 58 publications

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“…5,42 Based on our assumption regarding the varying neurocognitive impacts of triglycerides measured at different time points in life, one plausible explanation for our study findings is that lower triglycerides in older people may be attributable to their poorer nutritional intake and absorption, which are known predictors of cognitive decline and dementia. 43,44 By contrast, higher triglycerides within the normal to normal-high range may indicate plentiful food sources and healthy lifestyle, therefore a lower dementia risk. Because better nutritional status is commonly associated with higher LDL-c and triglyceride levels, we assume that if better nutritional status is protective against the development of dementia, we may have expected to find the low risk of dementia among participants with both high triglycerides and LDL-c.…”

Section: Discussionmentioning

confidence: 99%

Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults

Zhou,

Ryan,

Tonkin

et al. 2023

Neurology

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Background and Objectives:It has been suggested that higher triglyceride levels were associated with a lower risk of Alzheimer's disease. This study aimed to examine the association of triglycerides with dementia and cognition change in community-dwelling older adults.Methods:This prospective longitudinal study used data from the ASPREE randomized trial of adults aged ≥65 years without dementia or previous cardiovascular events at enrolment. The main outcome was incident dementia. Other outcomes included changes in composite cognition and domain-specific cognition (global cognition, memory, language and executive function, and psychomotor speed). The association between baseline triglycerides and dementia risk was estimated using Cox proportional-hazard models adjusting for relevant risk factors. Linear mixed models were used to investigate cognitive change. The analysis was repeated in a sub-cohort of participants with availableAPOE-ε4 genetic data with additional adjustment forAPOE-ε4 carrier status, and an external cohort (UK Biobank) with similar selection criteria applied.Results:The study included 18,294 ASPREE participants and 68,200 UK Biobank participants (mean age: 75.1 & 66.9 years; female: 56.3% & 52.7%; median [IQR] triglyceride:106 [80-142]mg/dl & 139 [101-193]mg/dl), with dementia recorded in 823 and 2,778 individuals over a median follow-up of 6.4 and 12.5 years, respectively. Higher triglyceride levels were associated with lower dementia risk in the entire ASPREE cohort (HR with doubling of TG: 0.82, 95% CI 0.72-0.94). Findings were similar in the sub-cohort of participants with APOE-ε4 genetic data (n=13,976), and in the UK Biobank cohort (HR was 0.82 and 0.83, respectively, all p≤0.01). Higher triglycerides were also associated with slower decline in global, composite cognition, and memory over time (p≤0.05).Discussion:Older adults with higher triglyceride levels within the normal to high-normal range had a lower dementia risk and slower cognitive decline over time compared to individuals with lower triglyceride levels. Higher triglyceride levels may be reflective of better overall health and/or lifestyle behaviors that would protect against dementia development. Future studies are warranted to investigate whether specific components within the total circulating pool of plasma triglycerides may promote better cognitive function, with the hope of informing the development of new preventive strategies.

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Section: Discussionmentioning

confidence: 99%

Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults

Zhou,

Ryan,

Tonkin

et al. 2023

Neurology

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Section: Discussionmentioning

confidence: 99%

“…20 Furthermore, studies using other tools such as Mini-Nutritional Assessment (MNA) and Modified Vulnerability Index also proved that malnutrition in elderly patients with hip fracture was closely related to their mortality. [21][22][23] Malnutrition is a risk factor for the poor postoperative outcome. 24,25 However, malnutrition is acknowledged as underrecognized and undertreated in health care.…”

Section: Discussionmentioning

confidence: 99%

Preoperative malnutrition as an independent risk factor for the postoperative mortality in elderly Chinese individuals undergoing hip surgery: a single-center observational study

Feng

Chen

Ping

et al. 2022

Therapeutic Advances in Chronic Disease

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Objective: Malnutrition is prevalent in elderly with hip fracture and higher than in community-dwelling older adults. Scarce studies have examined the association between preoperative malnutrition and postoperative mortality in elderly Chinese individuals with hip fracture. This study was designed to explore the effect of preoperative malnutrition on the postoperative long-term mortality in elderly Chinese individuals undergoing hip surgery. Methods: As a single-center observational study, this study included 263 consecutive patients above 70 years old with hip fracture and elective surgery. Preoperative nutritional status was evaluated by prognostic nutritional index (PNI). Patients were divided into one group with malnutrition (26 patients with PNI ⩽ 38) and the other group without malnutrition (169 patients with PNI > 38), respectively. Results: The overall malnutrition rate was 13.3% (26 patients). The postoperative long-term mortality rates of patients with and without malnutrition had statistically significant difference [10 patients (38.5%) and 32 patients (18.9%), p < 0.05]. Cox regression analysis showed that malnutrition (hazard ratio: 0.269, 95% confidence interval: 0.085–0.859, p < 0.05) and partial pressure of carbon dioxide (hazard ratio: 0.873, 95% confidence interval: 0.790–0.964, p < 0.05) were independent risk factors for the postoperative long-term mortality. Conclusion: This study demonstrated that preoperative malnutrition was an independent risk factor for the postoperative long-term mortality and resulted in a more than 2.5-fold increase of the postoperative long-term mortality in elderly Chinese individuals undergoing hip surgery.

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“…1 . The research was conducted in the form of a household survey, and the investigation methods of the CHCCS are outlined previously [ [11] , [12] , [13] ]. The present study was approved by the Ethics Committee of Hainan Hospital of Chinese People's Liberation Army General Hospital (Sanya, Hainan, No.…”

Section: Methodsmentioning

confidence: 99%

Associations between cardiac structure and function and depressive disorder: A centenarian study in China

Sun

Ping²,

Zhang³

et al. 2023

Heliyon

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Malnutrition is positively associated with cognitive decline in centenarians and oldest-old adults: A cross-sectional study

Cited by 31 publications

References 58 publications

Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults

Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults

Preoperative malnutrition as an independent risk factor for the postoperative mortality in elderly Chinese individuals undergoing hip surgery: a single-center observational study

Associations between cardiac structure and function and depressive disorder: A centenarian study in China

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