Malnutrition, sarcopenia, and cancer cachexia in gynecologic cancer

Morton, Molly; Patterson, Jenna; Sciuva, Jessica; Perni, Jaya; Backes, Floor; Nagel, Christa; O'Malley, David M.; Chambers, Laura M.

doi:10.1016/j.ygyno.2023.06.015

Cited by 18 publications

(12 citation statements)

References 120 publications

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“…These results coincide with our research, where the highest percentages of medium/high nutritional risk were found in patients with neoplastic (46.7%) and gastrointestinal (53.3%) diseases. In the case of cancer patients, malnutrition is increased by factors related to systemic inflammatory processes, metabolic disorders such as proteolysis and lipolysis, and factors associated with the disease or side effects of treatment, which generate decreased nutritional intake, lack of appetite, and abdominal distension [ 58 ]. These symptoms are also very frequent in patients with gastrointestinal diseases and are responsible for a greater deterioration of nutritional status among hospitalized patients [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Nutritional Risk Assessment in Critically Ill Patients Using the Malnutrition Universal Screening Tool (MUST)

Díaz Chavarro,

Molina-Recio,

Assis Reveiz

et al. 2024

JCM

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Background: Malnutrition is an underdiagnosed condition that negatively affects the clinical outcomes of patients, being associated with an increased risk of adverse events, increased hospital stay, and higher mortality. Therefore, nutritional assessment is a required and necessary process in patient care. The objective of this study was to identify the factors associated with nutritional risk by applying the Malnutrition Universal Screening Tool (MUST) scale in a population of critically ill patients. Methods: This was an observational, analytical, and retrospective study. Sociodemographic, clinical, hematological, and biochemical variables and their relationship with nutritional risk and mortality were analyzed. Results: Of 630 patients, the leading cause of admission was pathologies of the circulatory and respiratory system (50%); 28.4% were at high nutritional risk; and mortality was 11.6% and associated with nutritional risk, hemoglobin, and plasma urea nitrogen. Conclusions: The presence of gastrointestinal symptoms and the type of nutritional support received during hospitalization could increase the likelihood of presenting a medium/high nutritional risk, while polycythemia reduced this probability. An associative model was found to determine nutritional risk with an adequate specificity and diagnostic validity index.

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Section: Discussionmentioning

confidence: 99%

Factors Associated with Nutritional Risk Assessment in Critically Ill Patients Using the Malnutrition Universal Screening Tool (MUST)

Díaz Chavarro,

Molina-Recio,

Assis Reveiz

et al. 2024

JCM

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“…Different from malnutrition caused by simply insufficient energy intake, one of the leading causes of cancer-associated malnutrition is metabolic derangements caused by tumors ( 53 ). In addition, chemotherapy-induced nausea, vomiting symptoms, and decreased appetite further lead to a decrease in food intake, exacerbating malnutrition severity ( 54 ). A prospective multicenter cohort study has found that the pretreatment malnutrition based on GLIM criteria led to an increase in mortality for patients with non-Hodgkin’s lymphoma ( 52 ) and even affected the efficacy of immunotherapy ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Geriatric nutritional risk index as a predictor of prognosis in hematologic malignancies: a systematic review and meta-analysis

Yu,

Tian,

et al. 2023

Front. Nutr.

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ObjectiveRecent studies have reported inconsistent results regarding the association between geriatric nutritional risk index (GNRI) and clinical outcomes in patients with hematologic malignancies (HMs). We performed a meta-analysis to evaluate the effect of low GNRI on the overall survival (OS) and progression-free survival (PFS) in patients with HMs.Research Methods and ProceduresWe conducted the research via PubMed, Embase, and Cochrane Library databases to identify trials. Exploring the association between GNRI and prognosis in patients with HMs. A meta-analysis of OS and PFS was performed. Quality In Prognostic Studies instrument and Newcastle–Ottawa quality assessment Scale were used to assess the quality of included trials.ResultsFourteen studies enrolling 3,524 patients with HMs were included. Low GNRI was associated with shorter OS (Hazard ratio (HR) = 1.77; 95% CI = 1.44–2.18, p < 0.01) and PFS (HR = 1.63; 95% CI = 1.17–2.27, p < 0.01) in patients with HMs. In the subgroup analysis, GNRI was not significantly associated with prognosis in Chinese patients with HMs (OS, HR =1.33; 95% CI = 0.89–1.98, p = 0.16; PFS, HR = 1.70; 95% CI = 0.72–4.01, p = 0.23). For the subgroup with a GNRI cutoff value less than 98, there was no significant difference in PFS (HR = 1.34; 95% CI = 0.98–1.83, p = 0.06).ConclusionLow GNRI negatively impacted on the prognosis in patients with HMs. Prospective studies to identify the best cut-off value for GNRI are required.

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“…These results coincide with our research, where the highest percentages of medium/high nutritional risk were found in patients with neoplastic (46.7%) and gastrointestinal (53.3%) diseases. In the case of cancer patients, malnutrition is increased by factors related to systemic inflammatory processes, metabolic disorders such as proteolysis and lipolysis and factors associated with the disease or side effects of treatment, which generate decreased nutritional intake, lack of appetite and abdominal distension [50]. These symptoms are also very frequent in patients with gastrointestinal diseases and are responsible for a greater deterioration of nutritional status among hospitalized patients [51].…”

Section: Morbidity Gastrointestinal Symptoms and Nutritional Support ...mentioning

confidence: 99%

Assessment of Nutritional Status in Critically Ill Patients Using the Malnutrition Universal Screening Tool—MUST

Díaz Chavarro,

Molina-Recio,

Assis Reveiz

et al. 2023

Preprint

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Purpose: To identify factors linked with nutritional risk via the Malnutrition Universal Screening Tool scale assessment among critically ill patients from a hospital in Cali (Colombia). Materials and methods: A retrospective, analytical observational study was conducted with patients admitted to an intensive care unit (ICU). Sociodemographic, clinical, hematological, and biochemical parameters were analyzed, as well as their association with nutritional risk and patient mortality. Binary logistic regression was applied to outline nutritional risk. Results: Overall, 28.4% prevalence of elevated nutritional risk was observed. An association was found between nutritional risk and hemoglobin and hematocrit values, primary diseases accounting for ICU admission, gastrointestinal symptoms, and nutritional support route (p < 0.05). Mortality was 11.6% and it was correlated with nutritional risk, hemoglobin, and blood urea nitrogen. Conclusions: Gastrointestinal symptoms and the type of nutritional support received during hospitalization may increase nutritional risk, whereas polycythemia was a protective factor. We found an associative model to determine nutritional risk with high specificity and an adequate diagnostic validity index.

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Malnutrition, sarcopenia, and cancer cachexia in gynecologic cancer

Cited by 18 publications

References 120 publications

Factors Associated with Nutritional Risk Assessment in Critically Ill Patients Using the Malnutrition Universal Screening Tool (MUST)

Factors Associated with Nutritional Risk Assessment in Critically Ill Patients Using the Malnutrition Universal Screening Tool (MUST)

Geriatric nutritional risk index as a predictor of prognosis in hematologic malignancies: a systematic review and meta-analysis

Assessment of Nutritional Status in Critically Ill Patients Using the Malnutrition Universal Screening Tool—MUST

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