Malnutrition suppresses cell cycle progression of hematopoietic progenitor cells in mice via cyclin D1 down-regulation

Nakajima, Karina; Crisma, Amanda Rabello; Silva, Graziela B.; Rogero, Marcelo M.; Fock, Ricardo Ambrósio; Borelli, Primavera

doi:10.1016/j.nut.2013.05.029

Cited by 29 publications

(36 citation statements)

References 45 publications

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“…Similar findings were demonstrated in Wistar rats and in humans (CASTELUCCI et al, 2002;MONTE, 2000;NUNES et al, 2002). These observations have been attributed to changes in the cell proliferation of bone marrow precursors, which act in response to growth stimuli, causing a loss in development, precisely during the period in which the animal needs the most protein intake (NAKAJIMA et al, 2014).…”

Section: Discussionsupporting

confidence: 71%

“…This reaction originates from a hypothalamic stimulus of the adenohypophysis, resulting in the release of adrenocorticotropic hormones that, in the adrenal cortex, will release corticosteroids(DOMÍNGUEZ-GERPE; REY-MÉNDEZ, 2000;NAKAJIMA et al, 2014). These corticosteroids stimulate the use of metabolic tools, such as lipolysis and proteolysis, in an attempt to return to homeostasis.…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, the metabolic disarray and consequent excessive release of endogenous corticosteroids(DOMÍNGUEZ-GERPE; REY-MÉNDEZ, 2000;NAKAJIMA et al, 2014) led to an 81% increase in the ratio of water intake/body weight of the U animals, while the urine excretion/water consumption ratio was 12 % lower compared to the other two groups. This allows to infer that the imbalanced of metabolism leads to higher consumption and use of water to satisfy their metabolic needs.…”

Section: Discussionmentioning

confidence: 99%

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Metabolic effects of early protein undernourishment and renourishment in wistar rats

Baptista¹,

Cavalli²,

Luiz³

et al. 2015

Biosci. J.

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ABSTRACT:Malnutrition remains an important public health condition by affecting mostly children. The present study aimed to examine the effects of prenatal protein undernourishment and postnatal renourishment on the metabolism of pre-adult animals. Forty-five male Wistar rats originating from different litters were used. The Nourished (N, n=15) and Undernourished (U, n=30) groups were maintained on proteic and hypoproteic diets (20% and 5% casein, respectively) from the intrauterine phase until the end of the experiment. The Renourished group (R) contained 15 animals, randomly chosen from U group, that consumed the N diet beginning on day 21 (weaning). All groups were maintained until day 60. The experimental data was acquired daily for body weight, feed and water intake, feces and urine excretion. Data analysis was made with the total results and the ratio between them. The U group animals developed uniformly sparse hair late and experienced intense sweating, features that were not observed during the experiment in the R and N animals groups. The R group had the largest weight gain and feed and water intake ratio/weight at experimental period, followed by the N group animals. The final body weight and food intake decreased gradually in the order N-R-U, but none of the other parameters showed a statistical difference between the N and R animals. Compared to groups N and R, the U group animals consumed 90% and 81% more food and water, respectively. Protein undernourishment induced metabolic dysfunction in the U group animals. The similarity in the experimental parameters of the N and R groups suggests that an early feeding correction was effective in reestablishing the organic functions of the R group animals.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metabolic effects of early protein undernourishment and renourishment in wistar rats

Baptista¹,

Cavalli²,

Luiz³

et al. 2015

Biosci. J.

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“…Esse fato ocorre pela diminuição na expressão da ciclina D1 e aumento na expressão de p21/p27, indicando um comprometimento na proliferação celular resultante de alterações nas interações entre os compartimentos estromal e hemopoético, causadas por modificações no microambiente medular desencadeadas pela DPE (NAKAJIMA et al, 2014).…”

Section: Hemopoese E Desnutrição Proteico-energéticaunclassified

“…Nosso grupo tem demonstrado que a DPE provoca mudanças no perfil proliferativo das CTHs (NAKAJIMA et al, 2014) e prejudica a produção de precursores mielóides e linfóides, afetando a granulopoese (BORELLI et al, 2009), contribuindo para quadros de neutropenia (RUST et al, 2000), leucopenia e linfocitopenia (FOCK, BLATT, et al, 2010). Estas alterações hematológicas quantitativas podem ser observadas clinicamente durante períodos de carência nutricional e sugerem um estado de falência dos órgãos linfo-hemopoéticos (DE ANGELIS, 1986;ALVES, 1995;LEE e HERBERT, 1999).…”

Section: Hemopoese E Desnutrição Proteico-energéticaunclassified

Influência da L-glutamina sobre aspectos imunomodulatórios de células tronco mesenquimais medulares em situação de desnutrição proteico-energética

Santos¹

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Intravenous Glutamine Administration Modulates TNF-α/IL-10 Ratio and Attenuates NFkB Phosphorylation in a Protein Malnutrition Model

et al. 2016

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Protein malnutrition (PM) is a major public health problem in developing countries, affecting the inflammatory response and increasing susceptibility to opportunistic infections. For this reason, an adequate nutritional intervention can improve the quality of life of patients. Glutamine (GLN) is a nonessential amino acid, but can be considered "conditionally essential" for macrophage function in stress situations, in which it plays a role in the improvement of the inflammatory response. Concerning this issue, in the current study, it was of interest to evaluate some biological aspects of peritoneal cells from a protein malnutrition (PM) mouse model challenged with lipopolysaccharide (LPS) and treated intravenously with GLN. Two-month-old male Balb/c mice were subjected to a low-protein diet (2 % protein) and stimulated intravenously with LPS 1 h prior to the injection of 0.75 mg/kg GLN. Malnourished animals showed a reduced number of total peritoneal cells. Malnourished animals stimulated with LPS or LPS plus GLN did not show differences in peritoneal cell counts; however, the control group showed increased cellularity after LPS stimulus, which was reversed after GLN injection. Further, in the animals from both groups stimulated with LPS, GLN decreased the circulating levels of TNF-α and the levels of TNF-α produced by peritoneal cells; additionally, GLN decreased the IL-10 circulating levels in the malnourished animals stimulated with LPS. In addition, peritoneal cells of the control and malnourished groups stimulated with LPS showed a negative modulation of the NFkB signaling pathway after GLN injection. In conclusion, this study shows that GLN has the capacity to reduce TNF-α synthesis as well as to act as a negative regulator of NFkB phosphorylation, leading to a positive outcome in the control of TNF-α production.

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Malnutrition suppresses cell cycle progression of hematopoietic progenitor cells in mice via cyclin D1 down-regulation

Abstract: PM suppressed cell cycle progression mainly of HPC. This occurred via cyclin D1 down-regulation and p21/p27 overexpression attesting that BM microenvironment commitment observed in PM is affecting cell interactions compromising cell proliferation.

Cited by 29 publications

References 45 publications

Metabolic effects of early protein undernourishment and renourishment in wistar rats

Metabolic effects of early protein undernourishment and renourishment in wistar rats

Influência da L-glutamina sobre aspectos imunomodulatórios de células tronco mesenquimais medulares em situação de desnutrição proteico-energética

Intravenous Glutamine Administration Modulates TNF-α/IL-10 Ratio and Attenuates NFkB Phosphorylation in a Protein Malnutrition Model

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