Malnutrition, zinc supplementation and catch‐up growth: changes in insulin‐like growth factor I, its binding proteins, bone formation and collagen turnover

Doherty, Conor; Crofton, Patricia M.; Sarkar, Mitali; Shakur, M. S.; Wade, James B.; Kelnar, Christopher J. H.; Elmlinger, Martin W.; Ranke, Michael B.; Cutting, William A M

doi:10.1046/j.1365-2265.2002.01622.x

Cited by 34 publications

(66 citation statements)

References 22 publications

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“…79 The remaining five studies received funding from a combination of a commercial and an academic source (two studies 68,69,74,75 with academic sources either in the UK 68,69 or in South Africa 74,75 ), or an academic source and a government department (both in Kenya), 70 or an academic source and a charity (both based in the UK). 71,77 The age range of the children enrolled in each study varied.…”

Section: No Zinc Supplementmentioning

confidence: 99%

“…In three studies, 70,72,77 children ranged in age from a minimum of 1 year to a maximum of either 3 years, 70 5 years 72 or 7 years 77 (this study could be included because the mean age of participants was < 5 years of age). Six studies allowed for the inclusion of children under 1 year in age, with ages ranging from 6 months to about 2.5 years in one study, 71 6 months to 3 years in two studies, 68,69,79 and in three studies from either 6 months to 5 years, 74,75 5 months to 5 years 73 or 8 months to 2 years. 78 Only one study focused on children aged < 1 year.…”

Section: No Zinc Supplementmentioning

confidence: 99%

“…Three trials took place in Bangladesh, 68,69,73,77 two in India, 72,78 and one trial each in Pakistan, 79 Kenya, 70 Jamaica, 71 South Africa 74,75 and Chile. 76 Two studies were RCTs, 68,69,79 the remaining eight were CCTs [70][71][72][73][74][75][76][77][78] and all were conducted at a single centre. Three studies did not report on how the study was funded, 72,73,78 one study was funded by a commercial Children relapsed or died, n (%) 53 (10) 19 ( NR, not reported.…”

mentioning

confidence: 99%

“…Within this section, 10 trials [68][69][70][71][72][73][74][75][76][77][78][79] (12 publications Quantity and quality of research available: zinc A summary of the key characteristics of the 10 trials [68][69][70][71][72][73][74][75][76][77][78][79] can be seen in Table 51, with further details of the trials in Appendix 12. Three trials took place in Bangladesh, 68,69,73,77 two in India, 72,78 and one trial each in Pakistan, 79 Kenya, 70 Jamaica, 71 South Africa 74,75 and Chile. 76 Two studies were RCTs, 68,69,79 the remaining eight were CCTs [70][71][72][73][74][75][76]…”

mentioning

confidence: 99%

“…Thirteen trials [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82] were included that investigated the efficacy of treatments for correcting micronutrient deficiencies in children with SAM. Any supplements or combinations of supplements were eligible for inclusion, providing other review inclusion criteria (e.g.…”

mentioning

confidence: 99%

See 4 more Smart Citations

The effectiveness of interventions to treat severe acute malnutrition in young children: a systematic review.

Picot

Hartwell²,

Harris³

et al. 2012

Health Technol Assess

107

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTAThe effectiveness of interventions to treat severe acute malnutrition in young children: a systematic review NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs ...

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Section: No Zinc Supplementmentioning

confidence: 99%

Section: No Zinc Supplementmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

The effectiveness of interventions to treat severe acute malnutrition in young children: a systematic review.

Picot

Hartwell²,

Harris³

et al. 2012

Health Technol Assess

107

View full text Add to dashboard Cite

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Nutrition support in paediatrics

Marino

2018

Advanced Nutrition and Dietetics in Nutrition Support

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Effects of oral zinc supplementation on serum leptin levels in Ache males of eastern Paraguay

Bribiescas

2003

American J Hum Biol

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Significant population variation has been demonstrated in serum leptin levels, independent of adiposity. Included within these populations, Ache males have significantly lower leptin levels compared to American subjects with comparable adiposity. The underlying causes of these differences are not understood but zinc has been shown to be an important regulator of leptin in humans and rodents. Zinc deficiency is associated with somatic wasting and significant declines in circulating leptin levels. Zinc deficiency is common in underdeveloped regions and may therefore contribute to low leptin levels among Ache men. To ascertain the potential role of zinc on Ache male leptin profiles, zinc supplementation was conducted to observe leptin responsiveness. Ache males were given daily oral zinc supplementation (50 mg zinc gluconate) (n ¼ 8) or placebo (n ¼ 6) for 10 days. Serum leptin levels were measured on the first and last days of the treatment/placebo period. Despite supplementation exceeding triple the USDA recommended daily requirements, serum leptin levels did not change in the zinc-supplemented group (P ¼ 0.61) and were not significantly different from males receiving placebo (P ¼ 0.72). It is concluded that zinc is not likely to be a contributing factor in male Ache leptin profiles and that other sources of variation such as chronic energetic stresses affecting leptin production and perhaps receptor number or sensitivity should be considered. Am. J. Hum. Biol. 15:681-687, 2003.

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Malnutrition, zinc supplementation and catch‐up growth: changes in insulin‐like growth factor I, its binding proteins, bone formation and collagen turnover

Cited by 34 publications

References 22 publications

The effectiveness of interventions to treat severe acute malnutrition in young children: a systematic review.

The effectiveness of interventions to treat severe acute malnutrition in young children: a systematic review.

Nutrition support in paediatrics

Effects of oral zinc supplementation on serum leptin levels in Ache males of eastern Paraguay

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