Malon dialdehyde, nitrite and adrenomedullin levels in patients with premenstrual syndrome

Balat, Özcan; Dıkensoy, Ebru; Uğur, Mete Gürol; Atmaca, Ruşen; Çekmen, Mustafa; Yürekli, Muhittin

doi:10.1007/s00404-006-0269-1

Cited by 17 publications

(18 citation statements)

References 19 publications

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“…The increment in AM levels may be the result of a compensatory mechanism, and thus, may be a response to vascular reaction rather than oxidative distress 16 . Although the mechanism by which AM carries out its functions have not been fully clarified, it is thought that stimulation of the NO synthesis is one of the mechanisms 17 . Hattori et al.…”

Section: Discussionmentioning

confidence: 99%

Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea

Dıkensoy¹,

Balat²,

Pençe³

et al. 2008

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea

Dıkensoy¹,

Balat²,

Pençe³

et al. 2008

J of Obstet and Gynaecol

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“…In contrast to our a priori hypothesis, MDA levels were significantly higher during the first three weeks of the cycle as compared with day 28 while there was no significant association with PMS/MCAS. Two previous studies found no significant differences in MDA levels between PMS patients and controls (Balat et al, 2007;Duvan et al, 2011).…”

Section: Discussionmentioning

confidence: 66%

The Role of Immune and Oxidative Pathways in Menstrual-Cycle Associated Depressive, Physio-Somatic, Breast and Anxiety Symptoms: Modulation by Sex Hormones

Roomruangwong

Matsumoto

Michelin

et al. 2020

Preprint

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Objective: To examine whether 1) immune and nitro-oxidative stress (IO&NS) biomarkers are associated with premenstrual syndrome (PMS); and 2) changes in IO&NS biomarkers during the menstrual cycle (MC) are associated with PMS symptoms and plasma estradiol and progesterone. Methods: Forty-one women completed the Daily Record of Severity of Problems (DRSP) rating scale during 28 consecutive days and MC Associated Syndrome (MCAS) was diagnosed when the summed DRSP score during the MC is > 0.666 percentile. We assayed plasma levels of complement C3 and C4, highly sensitive C-reactive protein (hsCRP), haptoglobin (Hp), advanced oxidation protein products (AOPP), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP), sulfhydryl (-SH) groups and the activity of paraoxonase (PON)1 at days 7 (D7), 14 (D14), 21 (D21) and 28 (D28) of the MC. Results: All biomarkers, except hsCRP, showed significant alterations during the MC. Arylesterase (AREase) was lowered at D28, while LOOH increased at D14 and C4 at D21 in women with MCAS. The total DRSP score was predicted by the combined effects of C4 (positively) and AREase and malondialdehyde (MDA) (both inversely associated). Progesterone lowered levels of LOOH, AOPP and C3 and estradiol lowered levels of Hp while both sex hormones increased 4-(chloromethyl)phenyl acetate (CMPA)ase and AREase activities and levels of -SH groups. Conclusion: PMS/MCAS is not accompanied by a peripheral inflammatory response. Lowered MDA and antioxidant defenses and increased C4 may play a role in MC-associated symptoms while sex hormones may have a protective effect against oxidative stress toxicity.

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“…assessed the antioxidants levels such as glutathione, ceruloplasmin, SOD and lipid peroxidation product-MDA in PMS. They did not find any significant differences between the control and the PMS women in terms of antioxidant levels 26,27 . On the other hand, some studies reported that TAC levels in luteal phase were decreased in PMS women 1,5 .…”

Section: Discussionmentioning

confidence: 82%

“…Although estrogen is a potent antioxidant, its excessive activity in the luteal phase of PMS women may stimulate its pro-oxidant property leading to reduced TAC levels in these women 27,28 . Therefore, neuronal membrane dysfunction can be secondary to free radical-mediated pathology through toxic effects of free radicals on high ratio of polyunsaturated fatty acid in neuronal membrane, and may affect GABAergic system in PMS women 1 .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation for Premenstrual Syndrome-Related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial

Heidari

Amani

Feizi

et al. 2019

Sci Rep

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Premenstrual syndrome (PMS) is a common disorder in the reproductive age that negatively significant impacts on women’s quality of life. This randomized clinical trial study was undertaken to investigate the effect of vitamin D supplementation on inflammatory and antioxidant markers in 44 vitamin D deficient (25(OH)D < 20 ng/mL) students with PMS. Participants received either 50,000 IU vitamin D3 or a placebo pearl fortnightly for 4 months. At the baseline and in the last 2 months of intervention, participants were asked to complete the PMS Daily Symptoms Rating form along with taking the pearls and their blood samples were collected to assess serum levels of 25(OH)D3, Interleukin10 and 12 (IL-10, IL-12) and total antioxidant capacity (TAC). In vitamin D group, serum levels of IL-10 and IL-12 significantly decreased while TAC significantly increased post-intervention. There were significant differences regarding serum IL-12 and TAC levels between the two groups. Mean score of the total PMS symptoms showed significant improvement in 25(OH)D. Vitamin D supplementation seems to be an effective strategy to improve inflammation and antioxidant markers in vitamin D deficient women with PMS. This clinical trial was registered at Iranian Registry of Clinical Trials on 20/06/2018 (IRCT20180525039822N1).

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Malon dialdehyde, nitrite and adrenomedullin levels in patients with premenstrual syndrome

Abstract: Even though various stress symptoms are present in PMS, there is no change in the levels of MDA, an oxidative distress indicator but AM and NO may have a pathophysiological role on this enigmatic disease.

Cited by 17 publications

References 19 publications

Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea

Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea

The Role of Immune and Oxidative Pathways in Menstrual-Cycle Associated Depressive, Physio-Somatic, Breast and Anxiety Symptoms: Modulation by Sex Hormones

Vitamin D Supplementation for Premenstrual Syndrome-Related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial

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