Malondialdehyde and bipolar disorder: A short comprehensive review of available literature

Caldiroli, Alice; Auxilia, Anna Maria; Capuzzi, Enrico; Clerici, Massimo; Buoli, Massimiliano

doi:10.1016/j.jad.2020.05.001

Cited by 14 publications

(5 citation statements)

References 43 publications

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“…a p < 0.05 compared to all other groups. 2015; Eger et al, 2016), as observed in plasma as well as serum of bipolar patients in manic state (Machado-Vieira et al, 2007;Caldiroli et al, 2020). Thus, the LDX model is a valid procedure for the study of mania and antimanic-like drugs.…”

Section: Discussionmentioning

confidence: 93%

Andrographolide blocks 50-kHz ultrasonic vocalizations, hyperlocomotion and oxidative stress in an animal model of mania

Kanazawa

Radulski

Pereira

et al. 2021

Journal of Psychiatric Research

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Section: Discussionmentioning

confidence: 93%

Andrographolide blocks 50-kHz ultrasonic vocalizations, hyperlocomotion and oxidative stress in an animal model of mania

Kanazawa

Radulski

Pereira

et al. 2021

Journal of Psychiatric Research

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“…Particularly, high levels of pro-inflammatory cytokines and HPA axis hyper-reactivity were related to a history of violent suicide attempts among bipolar patients [ 55 ]. Moreover, a number of data support that over-inflammation, increased oxidative stress, and altered lipid profiles are interrelated phenomena explaining aggressive behavior or suicide attempts in BD [ 80 , 81 , 82 , 83 , 84 ].…”

Section: Discussionmentioning

confidence: 99%

Which Clinical and Biochemical Parameters Are Associated with Lifetime Suicide Attempts in Bipolar Disorder?

et al. 2022

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Introduction: Bipolar Disorder (BD) is a disabling condition with suicidal behavior as one of the most common adverse outcomes. The purpose of the present research is to investigate the relationship between lifetime suicide attempts and the clinical factors/biochemical parameters in a large sample of bipolar patients. Methods: A total of 561 patients, consecutively hospitalized for BD in Milan and Monza (Italy), were recruited. Data about the demographic and clinical variables, as well as the values of blood analyses, were collected. The groups identified according to the presence/absence of lifetime suicide attempts were compared using univariate analyses. Then, three preliminary binary logistic regressions and a final logistic regression model were performed to identify the clinical and biochemical parameters associated with lifetime suicide attempts in BD. Results: Lifetime suicide attempts in BD were predicted by a longer duration of untreated illness (DUI) (p = 0.005), absence of lifetime psychotic symptoms (p = 0.025), presence of poly-substance use disorders (p = 0.033), comorbidity with obesity (p = 0.022), a last mood episode of manic polarity (p = 0.044), and lower bilirubin serum levels (p = 0.002); higher total cholesterol serum levels showed a trend toward statistical significance (p = 0.058). Conclusions: BD patients with lifetime suicide attempts present unfavorable clinical features. Some specific biochemical characteristics of bipolar patients may represent potential markers of suicidal behavior and need to be better investigated to identify new targets of treatment in the framework of personalized medicine. These preliminary findings have to be confirmed by further studies in different clinical settings.

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“…However, the Central Nervous System is particularly vulnerable to oxidative stress for different reasons including the high request of oxygen resulting in excessive reactive oxygen species production, and the fact that neuronal membranes are rich in polyunsaturated fatty acids that are easily attacked by free radicals. In this regard, lipid peroxidation of neuronal membranes in turn negatively impacts on signal transduction, synaptic plasticity, mitochondrial function and ultimately on neuronal survival [100]. One of the final products of lipid peroxidation is Malondialdehyde (MDA), that represents a peripheral biomarker of oxidative stress of CNS and of lipid damage of neuronal membranes [101].…”

Section: Antioxidant Markersmentioning

confidence: 99%

Candidate Biological Markers for Social Anxiety Disorder: A Systematic Review

Caldiroli

Capuzzi

Affaticati

et al. 2023

IJMS

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Social anxiety disorder (SAD) is a common psychiatric condition associated with a high risk of psychiatric comorbidity and impaired social/occupational functioning when not promptly treated. The identification of biological markers may facilitate the diagnostic process, leading to an early and proper treatment. Our aim was to systematically review the available literature about potential biomarkers for SAD. A search in the main online repositories (PubMed, ISI Web of Knowledge, PsychInfo, etc.) was performed. Of the 662 records screened, 61 were included. Results concerning cortisol, neuropeptides and inflammatory/immunological/neurotrophic markers remain inconsistent. Preliminary evidence emerged about the role of chromosome 16 and the endomannosidase gene, as well as of epigenetic factors, in increasing vulnerability to SAD. Neuroimaging findings revealed an altered connectivity of different cerebral areas in SAD patients and amygdala activation under social threat. Some parameters such as salivary alpha amylase levels, changes in antioxidant defenses, increased gaze avoidance and QT dispersion seem to be associated with SAD and may represent promising biomarkers of this condition. However, the preliminary positive correlations have been poorly replicated. Further studies on larger samples and investigating the same biomarkers are needed to identify more specific biological markers for SAD.

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Malondialdehyde and bipolar disorder: A short comprehensive review of available literature

Cited by 14 publications

References 43 publications

Andrographolide blocks 50-kHz ultrasonic vocalizations, hyperlocomotion and oxidative stress in an animal model of mania

Andrographolide blocks 50-kHz ultrasonic vocalizations, hyperlocomotion and oxidative stress in an animal model of mania

Which Clinical and Biochemical Parameters Are Associated with Lifetime Suicide Attempts in Bipolar Disorder?

Candidate Biological Markers for Social Anxiety Disorder: A Systematic Review

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