Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients

Karaman, Ülkü; Çelik, Tuncay; Kıran, Tuğba Raika; Çolak, Cemil; Daldal, Nilgün

doi:10.3347/kjp.2008.46.4.293

Cited by 54 publications

(60 citation statements)

References 10 publications

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“…They also can bind to erythrocyte membranes, which are rich in polyunsaturated fatty acids (27), thereby causing membrane destruction and cellular damage (29). Karaman et al (33) reported that serum MDA concentrations were significantly increased in T. gondii-infected humans, and Yang et al (50) showed that serum concentrations of free oxygen radicals (NO, -OH, O2-) increased in T. gondii-infected mice. Our results are in accordance with Karaman et al (33), which suggested that erythrocyte MDA concentrations were significantly increased by T. gondii infection.…”

Section: Discussionmentioning

confidence: 99%

“…Karaman et al (33) reported that serum MDA concentrations were significantly increased in T. gondii-infected humans, and Yang et al (50) showed that serum concentrations of free oxygen radicals (NO, -OH, O2-) increased in T. gondii-infected mice. Our results are in accordance with Karaman et al (33), which suggested that erythrocyte MDA concentrations were significantly increased by T. gondii infection. In contrast, Engin et al (23) found no change in serum MDA concentrations of mice infected with T.gondii.…”

Section: Discussionmentioning

confidence: 99%

“…There is some evidence that oxidative stress is involved in the pathogenesis of toxoplasmosis in infected animals (4,5,19,23,28) and humans (3,10,33). However, such evidence is sparse, and no studies on oxidative stress have been conducted in T. gondiiinfected gerbils.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of oxidative stress, hematological and biochemical parameters during Toxoplasma gondii infection in gerbils

ÇINAR¹

2015

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:The aim of the present study was to investigate the alterations of oxidative stress, hematological and biochemical parameters in experimental infection caused by Toxoplasma gondii in gerbil. A total of 16 gerbil, 8 of which were control and 8 was infection group, were used in the study. The gerbils were infected by intraperitoneal inoculation of 5000 T. gondii RH strain tachyzoites. In group of, the gerbil were sacrificed at 7th day after inoculation. At the end of this period, blood samples collected and erythrocyte malondialdehyde (MDA) concentrations, superoxide dismutase (SOD), catalase (CAT) activities, plasma aspartat aminotransferase (AST) and alanine aminotranspherase (ALT) activities, total protein, albumin, globulin were determined. Besides, hematological parameters were analysed in whole blood. Aspartat aminotransferase and ALT activities and MDA concentrations and neutrophil percentage and total leukocyte counts increased significantly in infected group when compared to control. In infected group, SOD activities, albumin concentrations and lymhocyte percentage decreased when compared to control. The results of this study suggest that oxidative stress, hematological and biochemical alterations may contribute to the pathogenesis of toxoplasmosis in gerbils.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of oxidative stress, hematological and biochemical parameters during Toxoplasma gondii infection in gerbils

ÇINAR¹

2015

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…The B-cell counts were markedly reduced in both men and women with toxoplasmosis [22]. Karaman et al [209] found a significantly higher serum NO levels in patients with latent toxoplasmosis as compared with seronegative controls, and Dzitko et al [210] demonstrated markedly increased serum prolactin (a strong immunomodulator) levels in women with latent T. gondii infection. Prolactin has been show to enhance production of IFN-γ, IL-12, and IL-10, but not of TNF-α, in a stimulus specific manner [211].…”

Section: Humansmentioning

confidence: 99%

T. gondii Infection Acquired during Pregnancy and/or after Birth may be Responsible for Development of both Type 1 and 2 Diabetes Mellitus

Pr¹,

ota²

2013

J Diabetes Metab

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Recently, it was suggested that maternal T and potentially B cells transferred during pregnancy and/or the breast milk feeding and their encounter with the antigen in mesenteric lymph nodes might play a role in development of type 1 diabetes mellitus (T1DM). T. gondii infection during gestation and/or after birth may be responsible for development of both T1DM and T2DM in children, adolescents and adults because: a) maternal microchimerism in peripheral blood was demonstrated to be significantly higher in patients with T1DM compared to unaffected siblings and healthy subjects, b) transmission of T. gondii as a Trojan horse in various types of eukaryotic cells, including T and B lymphocytes, c) swallowing by the fetus of amniotic fluid containing infected leukocytes and other cells, d) elimination of T. gondii in the breast milk during lactation, e) involvement of mesenteric lymph nodes after oral infection with the parasite, and f) damage of the myenteric neurons during infection with the parasite in both the animals with streptozotocin-induced diabetes and diabetic patients. Moreover, a significantly lower occurrence of antibodies against T. gondii found in the sera of patients with T1DM compared with their first-degree family members or healthy controls may be due to their T and/or B cell exhaustion perspective caused by chronic infection with the parasite. This suggestion may be supported by the finding that latent toxoplasmosis was associated with markedly reduced lymphocyte B-cell counts responsible for production of antibodies, markedly lower serum IgG, IgM, and IgA levels, and a significant suppression of IL-2. On the other hand, patients with T2DM had increased anti-T. gondii antibodies significantly more frequently than respective controls. Impaired vascular endothelial function characteristic for the patients with diabetes mellitus may be at least in part due to the preferential T. gondii infection of endothelial cells. Vitamin D and minocycline exerted beneficial effects on development and clinical course of diabetes mellitus probably because of their immunomodulatory and antitoxoplasmatic activities. These data strongly suggest that the parasite play an important role in development of both types of diabetes mellitus.

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“…[4,5] Toxoplasmosis can cause serious pathologies including hepatitis, pneumonia, blindness and severe neurological disorders. [6] Toxoplasmosis may cause severe disorders in immunocompromised patients and in Pregnant women, because of high risk of transplacental transmission and the occurrence of multiple congenital lesions in the fetus. [7] During infection, the immune effecter cells are able to kill or inhibit its intracellular growth.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Oxidative Stress during Toxoplasmosis in Pregnant Women

Abdulrahman¹,

Mahmood²,

Abdul-Aziz³

2015

International Conference on Chemical, Agricultural and Biological Sciences (CABS-2015) Sept. 4-5, 2015 Istanbul (Turkey)

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Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients

Cited by 54 publications

References 10 publications

Evaluation of oxidative stress, hematological and biochemical parameters during Toxoplasma gondii infection in gerbils

Evaluation of oxidative stress, hematological and biochemical parameters during Toxoplasma gondii infection in gerbils

T. gondii Infection Acquired during Pregnancy and/or after Birth may be Responsible for Development of both Type 1 and 2 Diabetes Mellitus

Evaluation of Oxidative Stress during Toxoplasmosis in Pregnant Women

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