MALT-Lymphom der Bindehaut bei einem 13-jährigen Kind – fünf Jahre Rezidivfreiheit nach ausschließlich antibiotischer Behandlung

Abstract

We showed that extranodal MALT lymphomas of the conjunctiva can be successfully treated with antibiotics alone. At the start of therapy, the child was 13 years old. To our knowledge, this patient is the first child in Germany and one of the first in the world with ocular adnexal lymphoma who could be successfully treated with combined antibiotic therapy and who could be followed up for 5 years without relapse. Thus, we could avoid radiotherapy or chemotherapy in childhood and eliminate the risk of a therapy-induced secondary malignancy.

Classification, diagnosis, and management of conjunctival lymphoma

“…In several Korean and Italian studies, doxycycline was shown to be a viable treatment option for T1N0M0 OAL, with two of the largest studies claiming 5-year progression-free survival (PFS) rates of 55 and 60.9% [36, 84, 112–114]. It has also been successful in smaller case studies in areas not typically associated with C. psittaci infection [82, 87]. Statistically significant improvements in response rate and survival have been associated with localized TNM stage, absence of absolute lymphocytosis, presence of absolute neutropenia, confirmation of C. psittaci infection, and treatment with a double course of doxycycline [84, 113, 114].…”