Maltodextrin based proniosomes of nateglinide: Bioavailability assessment

Sahoo, Ranjan Ku.; Biswas, Nirmalendu; Guha, Arun K.; Kuotsu, Ketousetuo

doi:10.1016/j.ijbiomac.2014.05.075

Cited by 17 publications

(11 citation statements)

References 19 publications

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“…Amount of drug entrapment was measured using HPLC analysis [19,20]. HPLC method has been done according to Paul [21].…”

Section: Methodsmentioning

confidence: 99%

“…Total amount of the drug in the dosage form unit Entrapment efficiency was determined, and results were analyzed using Microsoft Excel 2016 and factorial ANOVA using IBM SPSS ® statistics version 20, Chicago, IL, USA. Amount of drug entrapment was measured using HPLC analysis [19,20]. HPLC method has been done according to Paul [21].…”

Section: Entrapment Efficiency (Ee%) =mentioning

confidence: 99%

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Optimization of Aceclofenac Proniosomes by Using Different Carriers, Part 1: Development and Characterization

et al. 2019

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In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The present study is intended to develop an optimized proniosomal aceclofenac formula by the use of different carriers. Aceclofenac proniosomes have been prepared by slurry method, and different carriers such as maltodextrin, mannitol, and glucose were tried. Prepared proniosomes characterized by differential scanning calorimetry (DSC) analysis and Fourier transform infrared (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added, powder X-ray diffractometry (XRD) confirmed the amorphous phase of the prepared proniosomes, and finally, the surfactant layer was observed by scanning electron microscopy (SEM). Aceclofenac physical state transformations were confirmed with all formulas but maltodextrin proniosomes exhibited solubility more than other formulations. HPLC method has been used to analyze the niosomes derived from proniosomes in terms of their entrapment capability and drug content. The obtained results revealed that aceclofenac proniosomes can be successfully prepared by using different carriers.

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“…Amount of drug entrapment was measured using HPLC analysis [19,20]. HPLC method has been done according to Paul [21].…”

Section: Methodsmentioning

confidence: 99%

Section: Entrapment Efficiency (Ee%) =mentioning

confidence: 99%

Optimization of Aceclofenac Proniosomes by Using Different Carriers, Part 1: Development and Characterization

et al. 2019

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“…The supernatant layer was taken and analyzed to determine the drug content using a suitable method. Maintenance of sink condition during this process is essential [62].…”

Section: Dialysis Tubingmentioning

confidence: 99%

An overview of characterizations and applications of proniosomal drug delivery system

Nimbalwar¹,

Gudalwar²,

Panchale³

et al. 2021

GSC Adv. Res. Rev.

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Proniosomal drug delivery system is a stable provesicular system in nanotechnology to overcome the drawbacks associated with other vesicular systems. These are water-soluble pro-vesicular drug carriers coated with a non-ionic surfactant which on hydration give niosomes. The system is encapsulated and shows a systemic and targeted delivery of poorly soluble drugs with increased bioavailability and decreased side effects. Here we have covered characterizations and applications of the proniosomal drug delivery system.

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“…After that, the solid mixture was scraped from the flask and placed in a bowl to grind into powders. The powders were sieved with a 100 mesh screen, collected and transferred into a glass bottle, sealed, and stored at room temperature [25][26][27] .…”

Section: Preparation Of Proniosomesmentioning

confidence: 99%

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2021

IJPSR

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The aim of the present study was to formulate and evaluate Budesonide proniosomes for enhancement of solubility and bioavailability. To develop and evaluate budesonide proniosomes was the main objective of this research work. For the preparation of proniosomes slurry, a method was used using different ratios of (cholesterol: surfactant) (1:1.5) with the help of carriers. For optimization of formulation Box-Behnken Design was used in that concentration of span 60, cholesterol, and maltodextrin. The prepared proniosomes were evaluated for particle size, entrapment efficiency, and in-vitro drug release (up to 6 h). Particle size, entrapment efficiency, and drug release of optimized batch (F14) were found to be 220.3 nm, 81.42%, and 30.71%, respectively. The data were fitted into a zero order model, and the correlation value found to be 0.952, indicating controlled release. Transformation of niosomes from proniosomes and morphology study of the optimized batch was studied by Inverted Microscopy and Transmission Electron Microscopy, etc. Statistical analysis of ex-vivo permeation enhancement assessed from the flux, permeability coefficient, and enhancement ratio was significantly higher for proniosomes as compared to control. During the stability study of 30 days, it was found that no signs of instability like agglomeration, crystallization, and variation in vesicle size and entrapment efficiency. The preparation method of Budesonide proniosomes was more efficient and more effective. The optimized Budesonide proniosomes did improve the solubility and bioavailability of budesonide and offer a new approach to enhance the targeted drug delivery system of poorly water-soluble drugs. INTRODUCTION:Budesonide is a locally acting glucocorticosteroid with an extensive, primarily hepatic, metabolism after oral administration. It is rapidly absorbed and biotransformed by cytochrome P450 (CYP) 3A to metabolites with negligible glucocorticoid activity 1.

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Maltodextrin based proniosomes of nateglinide: Bioavailability assessment

Cited by 17 publications

References 19 publications

Optimization of Aceclofenac Proniosomes by Using Different Carriers, Part 1: Development and Characterization

Optimization of Aceclofenac Proniosomes by Using Different Carriers, Part 1: Development and Characterization

An overview of characterizations and applications of proniosomal drug delivery system

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