Maltol, a Food Flavoring Agent, Attenuates Acute  Alcohol-Induced Oxidative Damage in Mice

Han, Ye; Xu, Qunying; Hu, Jiang‐Ning; Han, Xin-yue; Li, Wei; Zhao, Lichun

doi:10.3390/nu7010682

Cited by 83 publications

(89 citation statements)

References 47 publications

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“…At the end of the treatment, they were fasted overnight and animals in groups 2 and 4 were exposed to a single dose of 70% ethanol at 12 ml/kg body weight to induce oxidative stress. The dosage of ethanol used in this study has been documented to induce tissue toxicity and oxidative damage in rats [27]. After 12 hours of ethanol administration, the animals were anaesthetized using diethyl ether and were sacrificed.…”

Section: Animal Treatmentmentioning

confidence: 99%

Ameliorative Efficacy of Phytochemical Content of Corchorus olitorius Leaves against Acute Ethanol-induced Oxidative Stress in Wistar Rats

Airaodion

Ogbuagu

Ogbonnaya

et al. 2019

AJBGMB

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Aim: This study is aimed at investigating the ameliorative efficacy of methanolic extract of Corchorus olitorius leaves against acute ethanol-induced oxidative stress in Wistar rats. Methods: Fresh plants of C. olitorius were harvested from the Institute of Agricultural Research and Training, Ibadan. The leaves were dried and extracted using soxhlet apparatus and methanol as the solvent. The methanol was evaporated in a rotary evaporator at 35°C with a yield of 2.17 g which represents a percentage yield of 8.68%. Twenty adult male Wistar rats with body weight between 120 and 150 g were used for this study. They were randomly divided into four groups of five rats each. Animals in groups 1 and 2 were administered saline solution while those in groups 3 and 4 were administered C. olitorius extract for twenty-one days. The animals were administered the extract and saline solution at a dose of 4 mL per 100 g body weight 12 hourly via oral route of administration. At the end of the treatment, they were fasted overnight and animals in groups 2 and 4 were exposed to a single dose of 70% ethanol at 12 ml/kg body weight to induce oxidative stress. After 12 hours of ethanol administration, the animals were anaesthetized using diethyl ether and were sacrificed. Liver was excised, weighed and homogenized in 50 mmol/L Tris–HCl buffer (pH 7.4) and then centrifuged at 5000 × g for 15 minutes for biochemical analysis. Supernatants were immediately kept frozen for further analysis. Results: Ethanol-induced oxidative stress significantly increased the activities of AST, ALT, LDH, LPO, CAT, SOD and GPX but decrease GSH. These effects were regulated by C. olitorius administration. Conclusion: C. olitorius was able to remedy the effect of ethanol by regulating the oxidative stress biomarkers, thus possesses ameliorative efficacy against ethanol-induced oxidative stress and can protect the body against free radicals arising from oxidative stress.

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Section: Animal Treatmentmentioning

confidence: 99%

Ameliorative Efficacy of Phytochemical Content of Corchorus olitorius Leaves against Acute Ethanol-induced Oxidative Stress in Wistar Rats

Airaodion

Ogbuagu

Ogbonnaya

et al. 2019

AJBGMB

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“…It is known that a ROS scavenger can be used in the treatment of diseases such as anemia, tumor, nerve cell oxidative stress and diabetes-induced irreversible kidney damage [8][9][10][11]. As a growth inhibitor, maltol can be combined effectively with free radicals of body [12]; moreover, the ROS scavenging and antioxidant properties of maltol provide the molecule with antineoplastic [13][14][15][16], neuroprotective [17,18] and anti-apoptotic activities [19], and make it able to attenuate acute alcohol-induced liver injury and prevent oxidative damage in mice [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Playing with Structural Parameters: Synthesis and Characterization of Two New Maltol-Based Ligands with Binding and Antineoplastic Properties

et al. 2020

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Two maltol-based ligands, N,N′-bis((3-hydroxy-4-pyron-2-yl)methyl)-1,4-piperazine (L1) and N,N′,N′-tris((3-hydroxy-4-pyron-2-yl)methyl)-N-methylethylendiamine (L2), were synthesized and characterized. L1 and L2, containing, respectively, two and three maltol units spaced by a diamine fragment, were designed to evaluate how biological and binding features are affected by structural modifications of the parent compound malten. The acid-base behavior and the binding properties towards transition, alkaline-earth (AE) and rare-earth (RE) cations in aqueous solution, studied by potentiometric, UV-Vis and NMR analysis, are reported along with biological studies on DNA and leukemia cells. Both ligands form stable complexes with Cu(II), Zn(II) and Co(II) that were studied as metallo-receptors for AE and RE at neutral pH. L1 complexes are more affected than L2 ones by hard cations, the L1-Cu(II) system being deeply affected by RE. The structural modifications altered the mechanism of action: L1 partially maintains the ability to induce structural alterations of DNA, while L2 provokes single strand (nicks) and to a lesser extent double strand breaks of DNA.

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“…This method is used for comparing the ordinal scale responses such as the degree of pain, degree of injury, levels of satisfaction, preference or agreement (Dogan and Dogan, 2007). The ridit method has found applications in different fields of study, including epidemiology, biomedicine, psychology, animal studies, business management and behavioural studies (Wahi et al 1965;Fleiss et al 1979;Venkaiah et al 1992;Donaldson, 1998;Feinstein 2002;Kaushal, 2013;Han et al 2015;Sadhukhan et al 2015 andOriger et al 2015). An excellent review on the ridit analysis and its uses are presented by Brockett & Levine (1977), Selvin (1977), Jansen (1984), Fleiss (1986), Bullimore (1988), Beder& Heim (1990), Sermeus&Delesie (1996), Marion (1996), and IASSL ISSN-2424-6271 51 Bilgin(2003).…”

Section: Introductionmentioning

confidence: 99%

Application of ridit analysis to study the severity of anemia among children, adolescents and pregnant women in Andhra Pradesh

Boiroju

Rao

Venkaiah

2017

Sri Lankan J App Stats

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Maltol, a Food Flavoring Agent, Attenuates Acute Alcohol-Induced Oxidative Damage in Mice

Cited by 83 publications

References 47 publications

Ameliorative Efficacy of Phytochemical Content of Corchorus olitorius Leaves against Acute Ethanol-induced Oxidative Stress in Wistar Rats

Ameliorative Efficacy of Phytochemical Content of Corchorus olitorius Leaves against Acute Ethanol-induced Oxidative Stress in Wistar Rats

Playing with Structural Parameters: Synthesis and Characterization of Two New Maltol-Based Ligands with Binding and Antineoplastic Properties

Application of ridit analysis to study the severity of anemia among children, adolescents and pregnant women in Andhra Pradesh

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