Maltosylated polyethylenimine-based triple nanocomplexes of human papillomavirus 16L1 protein and DNA as a vaccine co-delivery system

Cho, Hee Jeong; Han, Su Eun; Im, Saewon; Lee, Young; Kim, Young Bong; Chun, Taehoon; Oh, Yu‐Kyoung

doi:10.1016/j.biomaterials.2011.03.004

Cited by 21 publications

(25 citation statements)

References 33 publications

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“…To improve vaccine delivery, a multifunctional system consisting of a protein antigen and its encoding plasmid linked to maltosylated PEI nanocomplexes has been developed (108). High charge density on PEI enabled complex formation with plasmid DNA, while the maltosylated moieties induced high-affinity bonding with protein antigens.…”

Section: Synthetic Polymer-based Particlesmentioning

confidence: 99%

Biomaterials for Nanoparticle Vaccine Delivery Systems

2014

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Subunit vaccination benefits from improved safety over attenuated or inactivated vaccines, but their limited capability to elicit long-lasting, concerted cellular and humoral immune responses is a major challenge. Recent studies have demonstrated that antigen delivery via nanoparticle formulations significantly improve immunogenicity of vaccines due to either intrinsic immunostimulatory properties of the materials or by co-entrapment of molecular adjuvants such as Toll-like receptor agonists. These studies have collectively shown that nanoparticles designed to mimic biophysical and biochemical cues of pathogens offer new exciting opportunities to enhance activation of innate immunity and elicit potent cellular and humoral immunity with minimal cytotoxicity. In this review, we present key research advances that were made within the last 5 years in the field of nanoparticle vaccine delivery systems. In particular, we focus on the impact of biomaterials composition, size, and surface charge of nanoparticles on modulation of particle biodistribution, delivery of antigens and immunostimulatory molecules, trafficking and targeting of antigen presenting cells, and overall immune responses in systemic and mucosal tissues. This review describes recent progresses in the design of nanoparticle vaccine delivery carriers, including liposomes, lipid-based particles, micelles and nanostructures composed of natural or synthetic polymers, and lipid-polymer hybrid nanoparticles.

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Section: Synthetic Polymer-based Particlesmentioning

confidence: 99%

Biomaterials for Nanoparticle Vaccine Delivery Systems

2014

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“…2 Subsequently, PEI has drawn more attention in biomedical field, especially as drug carriers, [13][14][15] biological labels 16,17 and vaccine adjuvants (Table 1). 18 Among all the delivered drugs, the most common ones are nucleic acids. PEI is the second acceptable nonviral nucleic acid transfer agent, besides poly-L-lysine (PLL).…”

Section: Introductionmentioning

confidence: 99%

Polyethylenimine-based micro/nanoparticles as vaccine adjuvants

Shen¹,

Li²,

Zhang³

et al. 2017

IJN

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Vaccines have shown great success in treating and preventing tumors and infections, while adjuvants are always demanded to ensure potent immune responses. Polyethylenimine (PEI), as one of the well-studied cationic polymers, has been used as a transfection reagent for decades. However, increasing evidence has shown that PEI-based particles are also capable of acting as adjuvants. In this paper, we briefly review the physicochemical properties and the broad applications of PEI in different fields, and elaborate on the intracellular processes of PEI-based vaccines. In addition, we sum up the proof of their in vivo and clinical applications. We also highlight some mechanisms proposed for the intrinsic immunoactivation function of PEI, followed by the challenges and future perspectives of the applications of PEI in the vaccines, as well as some strategies to elicit the desirable immune responses.

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“…However, using polymer chemistry tools, it is possible to structurally graft and/or encapsulate different forms (pDNA, protein, subunit, toxoid) of the antigen of choice to synergistically harness the duality of different vaccine classes. 151 Analogously, high-density surface grafting of antigenic material (not DNA) can result in increased crosslinking of antigen-specific TCRs and BCRs, which leads to lower thresholds for activations. 152, 153 For example, Irvine and co-workers synthesized layered lipid particles composed of entrapped malarial antigens and multivalent surface coatings.…”

Section: Vector Delivery Optionsmentioning

confidence: 99%

Biomaterials at the interface of nano- and micro-scale vector–cellular interactions in genetic vaccine design

2014

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The development of safe and effective vaccines for the prevention of elusive infectious diseases remains a public health priority. Immunization, characterized by adaptive immune responses to specific antigens, can be raised by an array of delivery vectors. However, current commercial vaccination strategies are predicated on the retooling of archaic technology. This review will discuss current and emerging strategies designed to elicit immune responses in the context of genetic vaccination. Selected strategies at the biomaterial-biological interface will be emphasized to illustrate the potential of coupling both fields towards a common goal.

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Maltosylated polyethylenimine-based triple nanocomplexes of human papillomavirus 16L1 protein and DNA as a vaccine co-delivery system

Cited by 21 publications

References 33 publications

Biomaterials for Nanoparticle Vaccine Delivery Systems

Biomaterials for Nanoparticle Vaccine Delivery Systems

Polyethylenimine-based micro/nanoparticles as vaccine adjuvants

Biomaterials at the interface of nano- and micro-scale vector–cellular interactions in genetic vaccine design

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