Maltreatment, MAOA, and Delinquency: Sex Differences in Gene–Environment Interaction in a Large Population-Based Cohort of Adolescents

Åslund, Cecilia; Nordquist, Niklas; Comasco, Erika; Leppert, Jerzy; Oreland, Lars; Nilsson, Kent W.

doi:10.1007/s10519-010-9356-y

Cited by 109 publications

(108 citation statements)

References 54 publications

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“…Findings in the opposite direction in the ACC during a flanker NoGo task suggested that increased emotional activity coincided with decreased inhibitory control. This finding is in line with previous studies reporting a sex-specific effect of MAOA on aggression (Byrd and Manuck 2014;Aslund et al 2011), which is likely due to the X-linked locus of the MAOA gene resulting in two copies in females and one copy in males.…”

Section: Discussionsupporting

confidence: 93%

“…In female subjects, findings suggested differential interaction patterns. Some studies reported an interaction of the high-expressing variant MAOA-H with early environmental adversity predicting the development of aggressive or antisocial behavior (Aslund et al 2011;Sjoberg et al 2007;Prom-Wormley et al 2009), while others confirmed MAOA-L as the risk allele in the interaction (Ducci et al 2008;Widom and Brzustowicz 2006) or reported no interaction at all (Frazzetto et al 2007). A potential sex dependence of the MAOA by environmental adversity could partly be explained by the X-linked transmission of the gene, resulting in females carrying two copies and males only one copy.…”

Section: Introductionmentioning

confidence: 99%

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Interacting effect of MAOA genotype and maternal prenatal smoking on aggressive behavior in young adulthood

et al. 2016

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Findings on the etiology of aggressive behavior have provided evidence for an effect both of genetic factors, such as variation in the monoamine oxidase A (MAOA) gene, and adverse environmental factors. Recent studies have supported the existence of gene × environment interactions, with early experiences playing a key role. In the present study, the effects of prenatal nicotine exposure, MAOA genotype and their interaction on aggressive behavior during young adulthood were examined. In a sample of 272 young adults (129 males, 143 females) from an epidemiological cohort study, smoking during pregnancy was measured with a standardized parent interview at the offspring's age of 3 months. Aggressive behavior was assessed between the ages of 19 and 25 years using the Young Adult Self-Report. DNA was genotyped for the MAOA 5' untranslated region variable number of tandem repeats polymorphism (VNTR). Results revealed a significant interaction between MAOA and smoking during pregnancy, indicating higher levels of aggressive behavior in young adults carrying the MAOA low-expressing genotype who had experienced prenatal nicotine exposure (n = 8, p = .025). In contrast, in carriers of the MAOA high-expressing genotype, maternal smoking during pregnancy had no effect on aggressive behavior during young adulthood (n = 20, p = .145). This study extends earlier findings demonstrating an interaction between MAOA genotype and prenatal nicotine exposure on aggressive behavior into young adulthood. The results point to the long-term adverse effects of smoking during pregnancy on the offspring's mental health, possibly underlining the importance of smoking cessation during pregnancy. According to the nature of the study (particularly sample size and power), analyses are exploratory and results need to be interpreted cautiously.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Interacting effect of MAOA genotype and maternal prenatal smoking on aggressive behavior in young adulthood

et al. 2016

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“…Similar results were found by Aslund et al (2011) and Nilsson et al (2011) (Table 1) examining, respectively, delinquent behaviour and high alcohol consumption. MAOA polymorphism was also found to enhance depressive symptoms but only among extensively maltreated youth (i.e.…”

Section: -25supporting

confidence: 86%

G × E interaction and neurodevelopment I. Focus on maltreatment

Nobile

Bianchi

et al. 2012

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences regularly appears in each issue of the Journal to describe relevant studies investigating the relationship between neurobiology and psychosocial psychiatry in major psychoses. The aim of these Editorials is to provide a better understanding of the neural basis of psycho pathology and clinical features of these disorders, in order to raise new perspectives in every-day clinical practice.Paolo Brambilla, Section Editor and Michele Tansella, Editor EPS G × E interaction and neurodevelopment I. Focus on maltreatment In a short series of articles, we will review the evidence for genotype by environment interaction (G × E) in developmental psychopathology. We will focus specifically on the characteristics of types of exposure assessed with respect to both their methods and findings. This article aims to review the studies exploring the effects of child maltreatment on children, adolescents and young adults closer in time to maltreatment experience, in a G × E perspective.

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“…In contrast, more inconsistency has been observed with regard to gender. While several studies replicated the original G 9 E in females (e.g., Weder et al 2009), others reported effects in the reverse direction, with the high activity allele conferring risk of violent behavior in females exposed to maltreatment (e.g., Aslund et al 2011), and others still found no interaction at all (e.g., Frazzetto et al 2007). As a potential source of heterogeneity, differences in MAOA expression between males and females have been discussed.…”

Section: Molecular Genetic Studies Of G Ementioning

confidence: 91%

“…A number of investigations confirmed the interaction between MAOA genotype and child maltreatment with regard to antisocial behavior in studies of maltreated children (e.g., Weder et al 2009), adolescents (e.g., Aslund et al 2011), and adults (e.g., Ducci et al 2008). In contrast, more inconsistency has been observed with regard to gender.…”

Section: Molecular Genetic Studies Of G Ementioning

confidence: 96%

Gene–Environment Interactions in the Etiology of Human Violence

Laucht

Brandeis

Zohsel

2013

Current Topics in Behavioral Neurosciences

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This chapter reviews the current research on gene-environment interactions (G × E) with regard to human violence. Findings are summarized from both behavioral and molecular genetic studies that have investigated the interplay of genetic and environmental factors in terms of influencing violence-related behavior. Together, these studies reveal promising evidence that genetic factors combine with environmental influences to impact on the development of violent behavior and related phenotypes. G × E have been identified for a number of candidate genes implicated in violence. Moreover, the reviewed G × E were found to extend to a broad range of environmental characteristics, including both adverse and favorable conditions. As has been the case with other G × E research, findings have been mixed, with considerable heterogeneity between studies. Lack of replication together with serious methodological limitations remains a major challenge for drawing definitive conclusions about the nature of violence-related G × E. In order to fulfill its potential, it is recommended that future G × E research needs to shift its focus to dissecting the neural mechanisms and the underlying pathophysiological pathways by which genetic variation may influence differential susceptibility to environmental exposures.

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Maltreatment, MAOA, and Delinquency: Sex Differences in Gene–Environment Interaction in a Large Population-Based Cohort of Adolescents

Cited by 109 publications

References 54 publications

Interacting effect of MAOA genotype and maternal prenatal smoking on aggressive behavior in young adulthood

Interacting effect of MAOA genotype and maternal prenatal smoking on aggressive behavior in young adulthood

G × E interaction and neurodevelopment I. Focus on maltreatment

Gene–Environment Interactions in the Etiology of Human Violence

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