Maltreatment, the Oxytocin Receptor Gene, and Conduct Problems Among Male and Female Teenagers

Andreou, Dimitrios; Comasco, Erika; Åslund, Cecilia; Nilsson, Kent W.; Hodgins, Sheilagh

doi:10.3389/fnhum.2018.00112

Cited by 26 publications

(29 citation statements)

References 58 publications

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“…Interestingly, results regarding anger were nonsignificant. Our findings are aligned with prior research demonstrating the link between maltreatment and conduct disorder and violent tendencies (Andreou, Comasco, Åslund, Nilsson, & Hodgins, ; Docherty, Kubik, Herrera, & Boxer, ). In comparison to nonmaltreated children, maltreated children also show higher levels of behavioral manifestations of negative affect.…”

Section: Discussionsupporting

confidence: 91%

Emotion Reactivity and Regulation in Maltreated Children: A Meta‐Analysis

et al. 2019

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The many adverse effects of child maltreatment make the scientific investigation of this phenomenon a matter of vital importance. Although the relationship between maltreatment and problematic emotion reactivity and regulation has been studied, the strength and specificity of these associations are not yet clear. We examine the magnitude of the maltreatment-child-emotion reactivity/regulation link. Studies with substantiated maltreatment involving children aged up to 18 were included, along with a smaller number of longitudinal studies (58 papers reviewed, encompassing more than 11,900 children). In comparison to nonmaltreated children, maltreated children experience more negative emotions, behave in a manner indicative of more negative emotion, and display emotion dysregulation. We outline several theoretical implications of our results.

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Section: Discussionsupporting

confidence: 91%

Emotion Reactivity and Regulation in Maltreated Children: A Meta‐Analysis

et al. 2019

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“…On the contrary, we aimed to focus on the single stressor of maternal verbal aggressive behavior in early infancy. Our null findings on OXTR variants rs53576 and rs2268498 are in contrast with our hypothesis and the studies [18], but in line with the study of Tollenaar et al [19], in which no interaction was shown of neither rs53576 nor rs2268498 and childhood maltreatment by retrospective recall. Interestingly, ample evidence suggests possible psychological resilience in rs53576 GG carriers, compared to A-allele carriers [44,45], due to their innate higher support seeking, higher levels of optimism, mastery, self-esteem and decreased emotion-focused coping following unsupportive responses, compared to the A-allele carriers.…”

Section: Discussionsupporting

confidence: 87%

“…Of note, evidence of gene-environment interaction of early life stress and rs53576 is contradictory and solely based on retrospective recall. After several kinds of maltreatment in childhood (emotional, physical or sexual abuse; emotional or physical neglect), G-allele carriers have shown increased depressive symptoms [17,18], and conduct problems (in females only) [19] and GG carriers showed a higher risk of emotional dysregulation [20], compared to A-carriers. However, a study on adults with clinically diagnosed depression and anxiety disorders showed no interaction of rs53576 with one or more types of childhood maltreatment [21].…”

Section: Introductionmentioning

confidence: 99%

Maternal verbal aggression in early infancy and child’s internalizing symptoms: interaction by common oxytocin polymorphisms

Smarius¹,

Strieder

Doreleijers

et al. 2019

Eur Arch Psychiatry Clin Neurosci

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Genetic predisposition of social sensitivity might affect vulnerability to develop psychopathology after early life stress exposure. This study examined whether maternal verbally aggressive behavior in early infancy interacts with oxytocin polymorphisms in developing internalizing symptoms at ages 5-6 and 11-12. In the Amsterdam-Born-Children-and-their-Development (ABCD) study, a large observational, population-based birth cohort, maternal verbally aggressive behavior was assessed in the 13th postnatal week by a self-report questionnaire. Internalizing symptoms at age 5-6 were assessed by maternal report (N = 969) and internalizing symptoms at age 11-12 were assessed by self-report (N = 750). Data on oxytocin receptor polymorphisms rs53576 and rs2268498 and oxytocin polymorphisms rs2740210 and rs4813627 were collected. If the child was carrier of rs2740210 CA/AA polymorphism, exposure to maternal verbally aggressive behavior (10.6%) was positively associated with general anxiety at age 5-6 and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.015, respectively). If the child was carrier of rs4813627 GG (wild type), exposure to maternal verbally aggressive behavior was negatively associated with anxiety sensitivity and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.022, respectively). After exposure to maternal verbally aggressive behavior in early infancy, oxytocin polymorphisms may partly determine a child's vulnerability to internalizing symptoms.

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“…This allele has also been related to prosopagnosia 53 , high levels of physical aggression and hostility 54 and low emotion recognition and resilience skills 55 . G-carriers showed higher levels of retrospective self-report of inhibition and adult separation anxiety 56 and, compared to A-carriers, are more vulnerable to antisocial behavior if they experience maltreatment 57 . This SNP also has interesting anatomical associations: the A allele was associated with larger amygdalar volume in healthy Asian adult 58, 59 , a phenotype typically identified in the early stages of autism 58 , and which correlated with heightened amygdala response during two functional magnetic resonance imaging (fMRI) tasks that involved viewing socially-relevant face stimuli 59 .…”

Section: Resultsmentioning

confidence: 91%

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

Theofanopoulou

Andirkó

Boeckx

et al. 2018

Preprint

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10Modern humans' lifestyle strongly depends on complex social skills like empathy, tolerance and cooperation. Variation in the oxytocin receptor (OXTR) and the arginine-vasopressin receptors (AVPR1A, AVPR1B genes) has been widely associated with diverse facets of social cognition, but the extent to which these variants may have contributed to the evolution of human prosociality remains to be elucidated. In this study, we compared the OXTR, AVPR1A and AVPR1B DNA sequences of modern humans to those of our closest extinct and extant relatives, and then clustered the variants we identified based on their distribution in the species studied. This clustering, along with the functional importance retrieved for each variant and their frequency in different modern-human populations, is then used to determine if any of the OXTR, AVPR1A and AVPR1B-variants might have had an impact at different evolutionary stages. We report a total of 29 SNPs, associated with phenotypic effects ranging from clearly pro-social to mixed or antisocial. Regarding modern human-specific alleles that could correlate with a shift towards prosociality in modern-humans, we highlight one allele in AVPR1A (rs11174811), found at high frequency and linked to prosocial phenotypes in modern humans, while the ancestral allele is associated with antisocial phenotypes. We also report three sites of putatively convergent changes between modern humans and bonobos (rs237897(A), rs2228485(G) and rs1042615(A)), and note the absence of such a convergent pattern between modern humans and chimpanzees. Finally, we observe the high concentration of 'modern human specific' alleles in vasopressin receptors not paralleled in the oxytocin receptor. 11 1 Introduction 12 Oxytocin (OXT) and vasopressin (AVP) are important neurotransmitters that function through their respective receptors to 13 regulate a diverse set of biological processes, such as pregnancy and uterine contractions, milk-ejection, copulation and orgasm, 14 attachment between mothers and their young, bond formation, suppression of stress, thermoregulation, olfactory processing, 15 eye-contact and recognition of familiar individuals 1 . OXT and AVP are closely related structurally and evolutionarily: they 16 have been argued to be the product of a local duplication event that took place before the origin of vertebrates 2 , and they only 17 differ in two (of the nine) amino acids, although they display differences at a functional level 1 . Each binds to their respective 18 receptor(s) (OXTR in the case of oxytocin, and AVPR1A, AVPR1B, and AVPR2 in the case of vasopressin), but their molecular 19 similarities allow for crosstalk in the brain and peripheral organs 3 . 20Variation in the genes that code for OXT and AVP receptors (OXTR and mainly AVPR1A and AVPR1B) have long been 21 associated with different social behaviors 4 . Single Nucleotide Polymorphisms (SNPs) in these genes in modern humans have 22 been claimed to be implicated in altruism, face recognition, stress levels and empathy, but also in socioco...

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Maltreatment, the Oxytocin Receptor Gene, and Conduct Problems Among Male and Female Teenagers

Cited by 26 publications

References 58 publications

Emotion Reactivity and Regulation in Maltreated Children: A Meta‐Analysis

Emotion Reactivity and Regulation in Maltreated Children: A Meta‐Analysis

Maternal verbal aggression in early infancy and child’s internalizing symptoms: interaction by common oxytocin polymorphisms

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

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