Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation

Abstract

Objective. Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F. Methods. The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. To assess the anti-inflammatory and antinociceptive effects of Maltoamide F on rats, the models of carrageenan-caused paw edema, xylene-induced ear edema, arachidonic-acid- (AA-) induced ear edema, formalin-caused plantar edema, and cotton-pellet-induced granuloma were established. Levels of TNF-α, PGE-2, and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA). Results. Maltoamide F was safe at oral doses of 1–10 mg/kg for rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) notably reduced carrageenan-induced edema percentage of paws in rats and decreased levels of PGE-2, IL-6, and TNF-α in homogenates of foot tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in foot tissues of formalin-induced rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) repressed AA-induced increase of ear thickness in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced xylene-induced weight of ear edema in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in homogenates of cotton ball granuloma of cotton-pellet-induced rats. Conclusions. Maltoamide F possessed anti-inflammatory and analgesic activity in inflammatory models of rats.

The Analgesic and Anti-inflammatory Effects of Partially Purified Polysaccharide Fractions of Cell-free Medium and Biomass of Spirulina platensis PCST5

“…It has also been demonstrated that the mega molecular polysaccharide sacran extracted from cyanobacterium Aphanothece sacrum has topical anti-inflammatory effects at concentrations of 0.01 and 0.05% (w/v) in the ultimate product ( 24 ). Moreover, Malyngamide F, a lipo-peptide of a filamentous cyanobacterium Lyngbya majuscule , showed anti-inflammatory and anti-nociceptive effects in animal models through reducing the levels of inflammatory cytokines, PGE-2, IL-6, and TNF-α ( 25 ).…”

Therapeutic Target Identification and Inhibitor Screening against Riboflavin Synthase of Colorectal Cancer Associated Fusobacterium nucleatum

“…The ZINC06804365 has been tested and reported as a potential inhibit for many signaling pathways such as Wnt-3a and also as having inhibitory activity against the Tankyrase-2 enzyme which reportedly has anti-cancer activities [ 74 ]. Malyngamide V has been widely studied for its anti-inflammatory and antinociceptive role [ 75 ] and CMNPD3609 possesses several antibacterial activities [ 76 ]. The diverse role of these compounds in different cancer and antimicrobial activities makes them a possible drug candidate to curb CRC caused by F. nucleatum .…”

Anti-Inflammatory Effect of 4,5-Dicaffeoylquinic Acid on RAW264.7 Cells and a Rat Model of Inflammation

“…In the early phase (0–3 h after injection), the inflammatory response is mediated by the release of inflammatory mediators such as histamine, 5-HT, and serotonin, whereas the late phase (3–5 h after injection) is mediated by the release of bradykinin, TNF-α, and leukotrienes and is sustained by increased levels of COX-2 and PGE 2 . Commercially available anti-inflammatory drugs target the late phase [ 28 , 29 , 30 , 31 ].…”