Mammalian bombesin-like peptides extend the intermeal interval in freely feeding rats

Thaw, Andrew Kurt; Smith, James C.; Gibbs, James

doi:10.1016/s0031-9384(98)00073-0

Cited by 32 publications

(15 citation statements)

References 12 publications

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“…The genotype distributions of rs1107179, rs17598561 and rs1051168 were similar in all four BMI groups (PX0. 19), whereas that of rs3809508 differed significantly (P ¼ 0.05). Subjects carrying the TT genotype presented a higher risk of obesity (adjusted OR (95% confidence interval) ¼ 2.85 (1.11-7.31), P ¼ 0.03) than C allele carriers.…”

Section: Resultsmentioning

confidence: 89%

“…17 Bombesin peptides are widely expressed in the pituitary, brain, pancreas, adrenal glands, gastrointestinal tract 17 and adipose tissue. 18 They are initially released from the gastro-intestinal tract in response to food intake 19 and their expression in adipose tissue is regulated by energy balance changes. 18 The peptides have a broad spectrum of biological effects, including smooth muscle contraction and changes in gastro-intestinal motility, the release of gastro-intestinal hormones and neurotransmitters, regulation of circadian rhythm, thermoregulation, anxiety/ fear responses and spinal sensory transmission.…”

Section: Introductionmentioning

confidence: 99%

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Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study

et al. 2009

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Objective: Neuromedin B (NMB) is a bombesin-like peptide, which inhibits food intake and modulates stress-related behaviour. An NMB gene polymorphism (P73T) has been earlier associated with obesity and abnormal eating behaviour in adults. Methods: The association between four NMB polymorphisms and obesity-related phenotypes was investigated in the Healthy Lifestyle in Europe by Nutrition in Adolescence cross-sectional study (n ¼ 1144, 12-17-year-old European adolescents). This population was genotyped for the NMB rs1107179, rs17598561, rs3809508 and rs1051168 (P73T) polymorphisms. Obesity was defined according to Cole et al. (BMJ 2000; 320: 1240-1243 criteria; eating behaviour was assessed by the Eating Behaviour and Weight Problems Inventory for Children (EWI-C) and the food choices and preferences questionnaires. Familial socioeconomic status (SES) was assessed through the parents' educational level. Results: Only the genotype distribution of rs3809508 differed according to obesity status, as the TT genotype was more frequent in obese than in non-obese adolescents (8.6% vs 3.1%, P ¼ 0.05; adjusted odds ratio for obesity (95% confidence interval): 2.85 (1.11-7.31), P ¼ 0.03). Moreover, TT subjects had higher body mass index (22.8 ± 4.4 kg m -2 vs 21.3 ± 3.7 kg m -2 , P ¼ 0.02), waist circumference (75.8±9.7 cm vs 72.2±9.3 cm, P ¼ 0.006), waist-to-hip ratio (0.84±0.14 vs 0.79±0.07, Po0.0001) and waist-to-height ratio (0.47 ± 0.06 vs 0.44 ± 0.55, P ¼ 0.002) than C allele carriers. The effects of this single nucleotide polymorphism on all anthropometric values were influenced by the maternal SES, in that a low maternal educational level aggravated the phenotype of adolescents carrying the TT genotype (interactions: Po0.02). No association with EWI-C scores was found, although sweet craving was a more frequent cause of between-meal food intake in TT subjects than in C allele carriers (24.3% vs 9.2%, P ¼ 0.01). Conclusion: In European adolescents, the TT genotype of the NMB rs3809508 polymorphism was associated with a higher risk of obesity. Moreover, the effects of this polymorphism on anthropometric values were influenced by the maternal educational level.

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Section: Resultsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study

et al. 2009

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“…The inter-rater reliability coefficient was 0.99. A sipper tube contact was operationally defined as any direct oral contact with the sipper tube longer than 3 sec [7,67]. The end of a meal was operationally defined as 5 consecutive min without a sipper tube contact [14,67,68].…”

Section: Sucrose Ingestionmentioning

confidence: 99%

Sex-dependent effects of early life inflammatory pain on sucrose intake and sucrose-associated hippocampal Arc expression in adult rats

Henderson

Nalloor

Vazdarjanova

et al. 2017

Physiology & Behavior

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We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory of a meal and inhibit the initiation of the next meal and the amount ingested during that meal. In support, we showed previously that (1) consuming a sucrose meal induces expression of the synaptic plasticity marker activity-regulated cytoskeleton-associated protein (Arc) in dHC neurons and (2) reversible inactivation of these neurons immediately following a sucrose meal accelerates the onset of the next meal and increases the size of that meal. These data suggest that hippocampal-dependent memory inhibits intake; therefore, the following experiments were conducted to determine whether hippocampal-dependent memory impairments are associated with increased intake. We reported recently that one episode of early life inflammatory pain impairs dHC-dependent memory in adult rats. The present study determined whether neonatal inflammatory pain also increases sucrose intake and attenuates sucrose-associated Arc expression. Male and female Sprague-Dawley rats were given an intraplantar injection of the inflammatory agent carrageenan (1%) on the day of birth and sucrose intake and sucrose-associated dHC Arc expression were measured in adulthood. Neonatal inflammatory pain increased sucrose intake in adult female and male rats, decreased sucrose-associated dHC Arc expression in female rats, and tended to have a similar effect on Arc expression in male rats. Neonatal inflammatory pain significantly decreased the interval between two sucrose meals in female but not in male rats. Morphine administration at the time of insult attenuated the effects of injury on sucrose intake. Collectively, these findings indicate that one brief episode of inflammatory pain on the day of birth has a long long-lasting, sex-dependent impact on intake of a palatable food in adulthood.

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“…injections in baboons and humans (Gibbs, 1985). In addition, brief vena caval infusions of GRP and NMB in rats, given alone or together at the onset of the first nocturnal meal, significantly reduced meal size and duration (Rushing et al, 1996), and bombesin or GRP given systemically extended the duration of the intermeal interval (Thaw et al, 1998). The suppression of glucose intake induced by systemic administration of GRP or bombesin was blocked by infusion of a GRPR antagonist into the fourth ventricle in rats (Ladenheim et al, 1996), and was absent in GRPR knockout mice (Hampton et al, 1998; Ladenheim et al, 2002), indicating that central GRPRs are critical in mediating the effects of peripheral bombesin and GRP on feeding.…”

Section: Grpr Regulation Of Cns Functionmentioning

confidence: 99%

Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target

Roesler¹,

Schwartsmann²

2012

Front. Endocrin.

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Neuropeptides acting on specific cell membrane receptors of the G protein-coupled receptor (GPCR) superfamily regulate a range of important aspects of nervous and neuroendocrine function. Gastrin-releasing peptide (GRP) is a mammalian neuropeptide that binds to the GRP receptor (GRPR, BB2). Increasing evidence indicates that GRPR-mediated signaling in the central nervous system (CNS) plays an important role in regulating brain function, including aspects related to emotional responses, social interaction, memory, and feeding behavior. In addition, some alterations in GRP or GRPR expression or function have been described in patients with neurodegenerative, neurodevelopmental, and psychiatric disorders, as well as in brain tumors. Findings from preclinical models are consistent with the view that the GRPR might play a role in brain disorders, and raise the possibility that GRPR agonists might ameliorate cognitive and social deficits associated with neurological diseases, while antagonists may reduce anxiety and inhibit the growth of some types of brain cancer. Further preclinical and translational studies evaluating the potential therapeutic effects of GRPR ligands are warranted.

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Mammalian bombesin-like peptides extend the intermeal interval in freely feeding rats

Cited by 32 publications

References 12 publications

Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study

Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study

Sex-dependent effects of early life inflammatory pain on sucrose intake and sucrose-associated hippocampal Arc expression in adult rats

Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target

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