Mammalian cell cultivation in space

Gmünder, Felix K.; Suter, Robert N.; Kiess, M.; Urfer, Roman; Nordau, Claudy-Gabrielle; Cogoli, Augusto

doi:10.1016/0273-1177(89)90066-5

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Although the discussion presented here concerns the novel possibility of cultivating mammalian cell cultures with the use of nanosatellites, the subject of conducting cell colonies in space is of (theoretical and experimental) investigations since around three decades now. [21][22][23] In particular, in July 1995 during the STS-70 Space Shuttle mission, experiments with colon carcinoma cells were performed by employing Bioreactor Demonstration System. The experiment was repeated in August 1997 during the STS-85 mission.…”

Section: Objectives and Challengesmentioning

confidence: 99%

A Concept of Biopharmaceutical Nanosatellite

Mielczarek

2019

New Space

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The article is a short overview of a proposal of a CubeSat type nanosatellite designed to conduct biopharmaceutical tests on the low earth orbit. Motivations behind the emerging demand for such solution nowadays and in the close future are emphasized. The possible objectives and challenges to be addressed in the planned biopharmaceutical CubeSat missions are discussed. In particular, it is hard to imagine progress of the space tourism and colonization of Moon and Mars without a wide-ranging development of pharmaceutics dedicated to be used in space. Finally, an exemplary layout of a 3U type CubeSat is presented. We underline that, thanks to recent development in both nanosatellite technologies and lab-on-a-chip type biofluidic systems, the proposed idea becomes now both feasible and relatively affordable.

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Section: Objectives and Challengesmentioning

confidence: 99%

A Concept of Biopharmaceutical Nanosatellite

Mielczarek

2019

New Space

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“…Outer space is a hostile environment for all lifeforms not only due to vacuum, high radiation, low atmospheric pressure, and extremely low temperature (Chuss, 2008), but also the absence of the geomagnetic field (Hargreaves, 1995;Sibeck & Lin, 2014). Astrobiologists have long been testing different organisms to find out if any multicellular organisms are able to survive in such extreme conditions (Langbein, 1986;Gmünder et al, 1989;Morrow et al, 1994). These studies are important from two points of view: first, it is important to identify organisms that are able to survive in unfavourable conditions, for example, on different planets or moons; second, we need to identify organisms which can potentially contaminate space probes sent to other celestial bodies and subsequently falsify research on search for extra-terrestrial life (Caplin, 2019;Vidaurri, 2019).…”

Section: Introductionmentioning

confidence: 99%

Tolerance of two anhydrobiotic tardigradesEchiniscus testudoandMilnesium inceptumto hypomagnetic conditions

Erdmann

Idzikowski

Kowalski

et al. 2021

PeerJ

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The open space is a hostile environment for all lifeforms not only due to vacuum, high radiation, low atmospheric pressure, and extremely low temperature, but also the absence of the geomagnetic field. The geomagnetic field protects Earth mainly from corpuscular radiation, that is, solar wind and cosmic radiation, but above all it influences organisms, including their cells, tissues and organs. Moreover, numerous studies conducted on plants and animals confirmed that hypomagnetic conditions (the term referring to all situations when the magnetic field is weaker than the typical geomagnetic field) have significant influence on the metabolism of living organisms. Although many studies dealt with a variety of aspects related mainly to the influence of hypomagnetic conditions on human health. Very few studies have considered the influence of hypomagnetic conditions on extremophiles. Astrobiologists have long been testing different extremofiles to find out if any multicellular organisms are able to survive in extreme conditions of open space. Among all multicellular extremophiles fit for such research, water bears (Tardigrada) are the most interesting. Not only are they one of the most resistant organisms on Earth, but results obtained from studies on these invertebrates can be extrapolated or applied to vertebrates (including humans). Despite this, studies on the influence of hypomagnetic conditions on tardigrades are rare, so far. In the present study, to test the influence of hypomagnetic conditions on the process of anhydrobiosis while entering and returning from anhydrobiosis, we used two terrestrial anhydrobiotic species that are Echiniscus testudo and Milnesium inceptum. To exclude the ambient magnetic field, experiments were carried out in a special magnetic field shielding chamber. In total, three experiments were conducted: (a) tardigrades in anhydrobiosis, (b) tardigrades entering anhydrobiosis and (c) tardigrades returning to active life. The obtained results clearly showed that even partial isolation from the geomagnetic field, that is, hypomagnetic conditions, has negative influence on anhydrobiotic abilities of both tested tardigrade species. In both species we observed lower survivability rate while entering anhydrobiosis, in anhydrobiotic state and returning to the active state. What is more, we observed a higher mortality rate in Ech. testudo than Mil. inceptum which suggest that different species response to the hypomagnetic conditions in different way. In conclusion, while current knowledge on the influence of hypomagnetic conditions on mortality of invertebrates is very limited, our results suggest that the presence of the magnetic field is a very important factor which should be considered in further research focused on potential survival of Earth organisms in outer space, spacecrafts or different planets and moons.

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Gravity Effects on Single Cells: Techniques, Findings, and Theory

Cogoli¹,

Gmünder²

1991

Advances in Space Biology and Medicine

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Mammalian cell cultivation in space

Cited by 4 publications

References 14 publications

A Concept of Biopharmaceutical Nanosatellite

A Concept of Biopharmaceutical Nanosatellite

Tolerance of two anhydrobiotic tardigradesEchiniscus testudoandMilnesium inceptumto hypomagnetic conditions

Gravity Effects on Single Cells: Techniques, Findings, and Theory

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