Mammalian Development in Space

Ronca, April E.

doi:10.1016/s1569-2574(03)09009-9

Cited by 27 publications

(35 citation statements)

References 58 publications

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“…Whereas that principle has not been actually demonstrated, several studies consistently showed a dose-dependant reaction at increasing levels of hypergravity, and opposite reactions in microgravity. A clear continuum of response to the level of gravity was found in the mammary metabolic rate (Plaut et al 2003), and the labor frequency contraction in parturient female rats (Ronca 2003). Inverse responses were also reported in some physiological adaptation to hypergravity or microgravity.…”

Section: Introductionmentioning

confidence: 87%

Ground-Based Researches on the Effects of Altered Gravity on Mice Development

Jamon

Serradj

2008

Microgravity Sci. Technol.

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This chapter reviews some consequences of the exposure to an altered gravity environment on the development of small mammals. A point is made on the possible existence of several critical periods, and their interactions, in relation with the multiple points of application of the gravity influence on developing organisms, and the need to coordinate the researches on the various structures concerned. The European effort to integrate a multidisciplinary exploration, from the genes expression to the behavioural output, in a topical team is presented, and a new French centrifuge facility for mice is described. A second part reports the preliminary results of a study on the motor performance of ageing (9 months) mice exposed to Hypergravity (2 g), in the new French centrifuge, between the 10th to 31 postnatal day, a key period for motor development in mice. This study shows for the first time that a transient exposure to an hypergravity environment during the period of motor development in the mouse produced an irreversible modification of the motor function.

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Section: Introductionmentioning

confidence: 87%

Ground-Based Researches on the Effects of Altered Gravity on Mice Development

Jamon

Serradj

2008

Microgravity Sci. Technol.

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“…In-flight experiments have shown an impact of microgravity during critical periods of mammalian development, especially on bones, muscles and brain (8). However, most of the observed effects were recovered upon return to Earth.…”

Section: Introductionmentioning

confidence: 99%

Simulated microgravity decreases apoptosis in fetal fibroblasts

Beck

Tabury

Moreels

et al. 2012

International Journal of Molecular Medicine

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Space travel is a major challenge for human beings. Especially, the mechanisms through which space conditions might alter animal development have been questioned for a long time. The two major physical stress factors that are of relevance in this context are space radiation and weightlessness. While it has been extensively shown that high doses of ionizing radiation induce deleterious effects on embryonic development, so far, little is known about the potential harmful effects of radiation in combination with microgravity on the developing organism. In the present study, we investigated the effects of simulated microgravity on irradiated STO mouse fetal fibroblast cells using a random positioning machine (RPM). Radiation-induced cell cycle changes were not affected when cells were subjected to simulated microgravity for 24 h. Moreover, no morphological differences were observed in irradiated samples exposed to simulated microgravity compared to cells that were exclusively irradiated. However, microgravity simulation significantly decreased the level of apoptosis at all doses as measured by caspase-3 activity and it prevented cells from undergoing radiation-induced size increase up to 1 Gy.

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“…Full recovery to normal activity modulation during the 360° lateral roll was recorded two weeks after microgravity exposure, whereas the further increase of developmental activity recorded in 1g controls was significantly delayed in the 3g exposed crickets (Fig. 16.15B) 2003). The lack of any effect of altered gravity on the gravity-related behavior but significant modifications in the neuronal activity points either to the possibility that the PSI is not included within the function of the neuronal network underlying the behavioral head response or, alternatively, that behavior undergoes a rapid normalization after return to 1g conditions supported by the proprioceptive gravity receptors of their legs (cf.…”

Section: Invertebratesmentioning

confidence: 90%

“…Neuroanatomical, neurophysiological, behavioral, and psychophysical studies in snails (Balaban et al, 2011), fish, amphibians, rodents, monkeys, and men has produced sufficient evidence for vestibular sensitization (Horn, 2008) in adult and developing animals. From COSMOS 1514, 'a trend suggesting increased vestibular sensitivity to rotation in flight pups' was described (Ronca, 2003). In young Oreochromis and Xenopus stage 45 tadpoles, the rVOR was increased during microgravity .…”

Section: Vestibular Sensitizationmentioning

confidence: 99%

“…Physiological activity of afferents matures during the first three postnatal weeks. Connections with the cerebellum, which is part of the control mechanisms of vestibulo-ocular and vestibulospinal reflexes, develop between the first and fourth post-natal week (Lannou et al, 1983;Ronca and Alberts, 2000;Ronca 2003;Raymond et al, 2003;Ronca et al, 2008).…”

Section: Studies In Higher Vertebratesmentioning

confidence: 99%

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