Mammalian enteral ventilation ameliorates respiratory failure

Okabe, Ryo; Chen‐Yoshikawa, Toyofumi F.; Yoneyama, Yoshimasa; Yokoyama, Yuka; Tanaka, Satona; Yoshizawa, Akihiko; Thompson, Wendy L.; Kannan, G. Vasantha; Kobayashi, Eiji; Date, Hiroshi; Takebe, Takanori

doi:10.1016/j.medj.2021.04.004

Cited by 27 publications

(13 citation statements)

References 23 publications

(32 reference statements)

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“…In 2015, we published the results of our clinical investigation describing arterial oxygenation improvement following enteral oxygen therapy [7]. Recently, similar data were obtained by Okabe et al [13] in an experimental setting, where oxygenated perfluorocarbon was administered rectally.…”

Section: Corresponding Authormentioning

confidence: 66%

Case report of successful treatment of clostridial colitis in a child using enteral oxygen therapy

Scherbakov¹,

Malisheva²,

Sukhotskaya³

et al. 2022

ait

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Section: Corresponding Authormentioning

confidence: 66%

Case report of successful treatment of clostridial colitis in a child using enteral oxygen therapy

Scherbakov¹,

Malisheva²,

Sukhotskaya³

et al. 2022

ait

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“…Oxygen carriers for enteral ventilation include oxygen gas, oxygen microbubbles, and perfluorocarbons. Previous studies showed oxygen gas infusion requires mucosal damage to deliver sufficient oxygen 9 and, therefore, is unacceptable for humans. While oxygenated microbubble infusion is effective when given as a relatively high-dose bolus injection ( i .…”

Section: Discussionmentioning

confidence: 99%

“…showed that intrarectal administration of oxygenated perfluorocarbons led to systemic oxygenation in animals with respiratory failure. 9 Another preprint study by Mountford et al. demonstrated that delivering oxygen microbubbles increased systemic blood oxygen levels in smoke-inhaled hypoxic pig models.…”

Section: Introductionmentioning

confidence: 99%

Enteral liquid ventilation oxygenates a hypoxic pig model

Fujii¹,

Yoneyama²,

Kinebuchi³

et al. 2023

iScience

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“…Experiments in rodent and porcine models, inspired by loaches that use intestinal air breathing to survive under extensive hypoxia, demonstrated that intra-rectal O2 delivery attains significant systemic oxygenation (Okabe et al, 2021;Mountford et al, 2021).…”

Section: Nitrogen (N2)mentioning

confidence: 99%

Biological Relevance of Intestinal Gases in Healthy Humans

Tozzi¹,

Minella²

2022

Preprint

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Intestinal gases are usually discarded as physiologically inert, useless sub-products of colonic fermentation that must be expelled to prevent discomfort and meteorism. Starting from the observation that many living beings use exogenous and/or endogenous gases to attain evolutionary benefits, we question whether intestinal gases in healthy humans could have underestimated physiological effects, either intestinal or extra-intestinal. We examine gaseous volume, composition, source and local distribution in proximal as well as distal gut, providing extensive data that may serve as reference for future studies. We analyze each one of the most abundant intestinal gases and describe their diffusive patterns, active trans-barrier transport dynamics, chemical properties, intra-/extra-intestinal metabolic effects mediated by intracellular, extracellular, paracrine and distant actions. Discussing the physical properties of the whole intestinal gaseous mixture, we illustrate how changes in volume/pressure can be generated by two different mechanisms, namely, physical muscular gut contraction and biological colonic fermentation, with quite different metabolic outcomes. The experimental gas laws suggest that the gaseous exchanges between lumen and bloodstream are impaired by muscular contraction and improved by muscular relaxation. In turn, the surface-area-to-volume ratio suggests that the gaseous exchanges are impaired by microorganismal overproduction and improved by microorganismal reduction. Further, theoretical stochastic approaches from probability theory indicate that the non-turbulent, random paths of gas molecules inside colonic haustra do not homogenously spread over the whole mucosal surface. This means that the intestinal area available for lumen/blood metabolic exchanges is much less than expected not just in disease states, but also in healthy individuals.

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Mammalian enteral ventilation ameliorates respiratory failure

Abstract: Okabe et al. report the exploitation of intestinal breathing phenomenon in mammalian pre-clinical models, potentially offering an additional route of O 2 administration to patients who are in critical need of immediate respiratory support.

Cited by 27 publications

References 23 publications

Case report of successful treatment of clostridial colitis in a child using enteral oxygen therapy

Case report of successful treatment of clostridial colitis in a child using enteral oxygen therapy

Enteral liquid ventilation oxygenates a hypoxic pig model

Biological Relevance of Intestinal Gases in Healthy Humans

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