Mammalian Muscle Receptors and Their Central Actions

Matthews, P. B. C.; Bagby, Roland M.

doi:10.1249/00005768-197400620-00005

Cited by 534 publications

(643 citation statements)

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“…Five imps/s was considered to be a minimally important difference because this change in muscle spindle discharge frequency likely represents a 1.25 mm change of muscle length (17). The effect of conditioning duration on ΔMIF or ΔMF was compared with a one-way analysis of variance (ANOVA) using a randomized complete block design.…”

Section: Methodsmentioning

confidence: 99%

Time course for the development of muscle history in lumbar paraspinal muscle spindles arising from changes in vertebral position

Ge¹,

Pickar²

2008

The Spine Journal

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Background Context-In neutral spinal postures with low loading moments the lumbar spine is not inherently stable. Small compromises in paraspinal muscle activity may affect lumbar spinal biomechanics. Proprioceptive feedback from muscle spindles is considered important for control of muscle activity. Because skeletal muscle and muscle spindles are thixotropic, their length history changes their physical properties. The present study explores a mechanism that can affect the responsiveness of paraspinal muscle spindles in the lumbar spine.

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Section: Methodsmentioning

confidence: 99%

Time course for the development of muscle history in lumbar paraspinal muscle spindles arising from changes in vertebral position

Ge¹,

Pickar²

2008

The Spine Journal

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“…The potential advantages of feedback control of voluntary movements by means of muscle spindles are well recognized (Merton, 1953;Matthews, 1972Matthews, , 1981Prochazka & Hulliger, 1983). However, a clear appreciation of the actual role of muscle spindles in any given type of movement has always been hampered because of uncertainties regarding the patterns of activity occurring in the ã_motor supply, which can dramatically alter the response of primary and secondary spindle afferents to muscle length changes.…”

mentioning

confidence: 99%

Fusimotor Influence on Jaw Muscle Spindle Activity during Swallowing‐Related Movements in the Cat

Taylor

Hidaka

Durbaba

et al. 1997

The Journal of Physiology

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The activity patterns of muscle spindle afferents in jaw‐closer muscles were studied during reflex swallowing movements in anaesthetized cats. Simultaneous records were made of the electromyogram (EMG) in masseter and anterior digastric muscles and of the unloaded jaw movements. The underlying patterns of fusimotor activity were deduced by comparing afferent discharges occurring during active swallowing with those occurring when exactly the same movements were imposed passively. The interpretation of spindle behaviour was greatly facilitated by characterizing the afferents according to the evidence for their contact with the various intrafusal muscle fibres, derived from testing with succinylcholine. It was also valuable to have two different types of afferent recorded simultaneously. There was clear evidence of fusimotor activity occurring during active jaw closing so as to oppose the spindle silencing. This effect was most marked in b2c‐type afferents (probably secondaries) and was therefore attributed to a modulation of static fusimotor discharge approximately in parallel with α‐activity. Afferents with evidence of bag1 fibre contacts (primaries) showed much greater sensitivity to muscle lengthening during active movement than when the movement was imposed. This difference was exaggerated when anaesthesia was deepened for the passive movements. This was interpreted as evidence for a higher level of dynamic fusimotor activity maintained during active movements than at rest. The results support the view that for a variety of active jaw movements, static fusimotor neurone firing is modulated roughly in parallel with α‐activity but leading it so as to counteract spindle unloading. Dynamic fusimotor neurone firing appears to be set at a raised level during active movements. Anaesthesia appears to depress activity in the α‐motoneurones more than in γ‐motoneurones.

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“…7B) which might not have been related to the stretch reflex mechanism. However, the EMG voltage during stretch increased with the tension increase and therefore guarantees that the tension increase was due to a neural mechanism and not caused simply by the length-tension characteristics of the muscle, which would have produced a pseudo-stretch reflex (Matthews, 1972). This effect is clearly illustrated in the integrated EMG traces of Figure 3a.…”

Section: Resultsmentioning

confidence: 75%

A Pharmacological Study of the Adrenergic Mechanisms Involved in the Stretch Reflex of the Decerebrate Rat

Commissiong

Sedgwick

1974

British J Pharmacology

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1The effects of catecholamine precursors, enzyme inhibitors, and monoamine depletors have been studied on the stretch reflex in the decerebrate rat. 2 L-DOPA alone had a biphasic effect, facilitation followed by inhibition and recovery of the reflex.3 About 10% of the preparations did not develop decerebrate rigidity. These preparations did not have a stretch reflex. Within 1 to 5 min of the injection of L-DOPA in these inactive preparations, a stretch reflex could be elicited. 4 Control experiments indicate that L-DOPA was acting centrally after decarboxylation. 5 D L-dihydroxyphenylserine had an inhibitory effect, without a preceding facilitation. 6 When L-DOPA was preceded by diethyldithiocarbamate (i.v.) or FLA-63 (i.p.), the predominant response was a sustained facilitation, without an accompanying inhibition. 7 It is concluded that in the decerebrate rat, increased stretch reflex activity is associated with increased central levels of dopamine, and decreased stretch reflex activity with increased central levels of noradrenaline. The results are discussed with reference to the possibility that dopamine acts by liberating 5-hydroxytryptamine.

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Mammalian Muscle Receptors and Their Central Actions

Cited by 534 publications

References 0 publications

Time course for the development of muscle history in lumbar paraspinal muscle spindles arising from changes in vertebral position

Time course for the development of muscle history in lumbar paraspinal muscle spindles arising from changes in vertebral position

Fusimotor Influence on Jaw Muscle Spindle Activity during Swallowing‐Related Movements in the Cat

A Pharmacological Study of the Adrenergic Mechanisms Involved in the Stretch Reflex of the Decerebrate Rat

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