Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries

Bukovský, Antonín; Caudle, Michael R.; Gupta, Satish Kumar; Svetlikova, Marta; Selleck-White, Rachel; Ayala, Alena M.; Domı́nguez, Roberto

doi:10.4161/cc.7.5.5453

Cited by 35 publications

(42 citation statements)

References 14 publications

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“…Former observations indicating that neo-oogenesis occurs in adult human and mouse ovaries (Bukovsky et al, 1995(Bukovsky et al, , 2004Johnson et al, 2004;Kerr et al, 2006;Bukovsky et al, 2008a) were recently confirmed by an evidence that cultured OSC transplanted into ovaries of sterilized mice could produce new oocytes and offsprings (Zou et al, 2009). It has been indicated that these observations support the possibility to restore fertility in women with a premature ovarian failure (POF; Gougeon, 2010).…”

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confidence: 56%

“…No staining of oocytes was observed in three younger women studied during the mid-and late luteal phases and in PCO ovaries (Bukovsky et al, 2008a). Panel J shows SCP3 expression in the testes of 2-month-old rat (positive control).…”

Section: Localization Of Scp3 In Adult Human and Monkey Ovariesmentioning

confidence: 99%

“…We studied SCP3 expression and reported that using the same SCP3 antibody, the immunoreactivity with segments of TA and OSC, and in some oocytes of primordial follicles in functional adult human and monkey ovaries was detected (Bukovsky et al, 2008a). Functional ovaries without evidence of ongoing follicular renewal (midfollicular, mid-and late luteal phases) indeed lacked staining for SCP3 in TA and at the ovarian surface (ta and os, Fig.…”

Section: Localization Of Scp3 In Adult Human and Monkey Ovariesmentioning

confidence: 99%

“…Although the ''storage'' concept on the preservation of oocytes from the period of ovarian development in humans and most other mammalian species is still prevailing, the studies of follicular renewal during adulthood in humans (Bukovsky et al, 1995(Bukovsky et al, , 2004(Bukovsky et al, , 2008a and laboratory rodents (Johnson et al, 2004(Johnson et al, , 2005Bukovsky et al, 2005aBukovsky et al, , 2007Kerr et al, 2006) have awoken the curiosity of many scientists globally.…”

Section: The Oocyte Storage Versus Continued Formation Conceptmentioning

confidence: 99%

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Ovarian Stem Cell Niche and Follicular Renewal in Mammals

Bukovský

2011

The Anatomical Record

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Stem cell niche consists of perivascular compartment, which connects the stem cells to the immune and vascular systems. During embryonic period, extragonadal primordial germ cells colonize coelomic epithelium of developing gonads. Subsequently, ovarian stem cells (OSC) produce secondary germ cells under the influence of OSC niche, including immune system-related cells and hormonal signaling. The OSC in fetal and adult human ovaries serve as a source of germ and granulosa cells. Lack of either granulosa or germ cell niche will result in premature ovarian failure in spite of the presence of OSC. During perinatal period, the OSC transdifferentiate into fibroblast-like cells forming the ovarian tunica albuginea resistant to environmental threats. They represent mesenchymal precursors of epithelial OSC during adulthood. The follicular renewal during the prime reproductive period (PRP) ensures that there are fresh eggs available for a healthy progeny. End of PRP is followed by exponentially growing fetal genetic abnormalities. The OSC are present in adult, aging, and postmenopausal ovaries, and differentiate in vitro into new oocytes. During in vitro development of large isolated oocytes reaching 200 lm in diameter, an ancestral mechanism of premeiotic nurse cells, which operates during oogenesis in developing ovaries from invertebrates to mammalian species, is utilized. In vitro developed eggs could be used for autologous IVF treatment of premature ovarian failure. Such eggs are also capable to produce parthenogenetic embryos like some cultured follicular oocytes. The parthenotes produce embryonic stem cells derived from inner cell mass, and these cells can serve as autologous pluripotent stem cells. Anat Rec, 294:1284Rec, 294: -1306Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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mentioning

confidence: 56%

Section: Localization Of Scp3 In Adult Human and Monkey Ovariesmentioning

confidence: 99%

Section: Localization Of Scp3 In Adult Human and Monkey Ovariesmentioning

confidence: 99%

Section: The Oocyte Storage Versus Continued Formation Conceptmentioning

confidence: 99%

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Ovarian Stem Cell Niche and Follicular Renewal in Mammals

Bukovský

2011

The Anatomical Record

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“…After sexual maturation, expression of mammalian SYCP family members is specific to testis and restricted to meiotic prophase I spermatocytes (Offenberg et al 1998, Yang et al 2006. Interestingly, recent reports demonstrate the expression of mammalian SYCP family members in adult human ovaries (Bukovsky et al 2008) and show that transplanted female germline stem cells derived from adult mouse ovaries underwent oogenesis and the mice produced offspring (Zou et al 2009). To our knowledge, less is known about tissue-and cell-specific expression of SYCP family members in chickens.…”

Section: Discussionmentioning

confidence: 99%

Expression pattern of meiosis associated SYCP family members during germline development in chickens

Zheng

Rengaraj²,

Choi³

et al. 2009

Reproduction

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Synaptonemal complexes (SCs) are associated with synapsis of homologous chromosomes, chiasmata distribution, recombination and segregation of chromosomes during the extended prophase of meiosis I. Three isoforms of SC proteins, SYCP1, SYCP2 and SYCP3, were identified as the structural proteins of SCs, and may be involved in the assembly and disassembly of SCs. The aim of this present study is to determine the pattern of expression of chicken homologues of SYCP family members during ovarian and testicular development. Protein sequence analysis using CLUSTAL X revealed that the sequences and potential phosphorylation sites of chicken SYCP family proteins were highly conserved with mammalian homologues of SYCP family proteins. Quantitative real-time-PCR and in situ hybridisation analysis revealed that chicken SYCP family members were differentially expressed during ovarian and testicular development. During ovarian development, all chicken SYCP family members were detected in primordial germ cells (PGCs) until embryonic day (E) 8.0; the expression continued in proliferating pre-meiotic oogonia until E15.5 and was upregulated in meiotic prophase I oocytes until hatching. After hatching, all chicken SYCP family members were detected at a low level until 24-weeks-old. During testicular development, all chicken SYCP family members were detected in PGCs until E13.0; the expression continued in pro-spermatogonia and proliferating spermatogonia for up to 8 weeks, and was upregulated in meiotic prophase I spermatocytes in adults. Our data demonstrate the expression pattern of meiosis associated SYCP family members during ovarian and testicular development in chickens.

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