Mammalian Nudt15 hydrolytic and binding activity on methylated guanosine mononucleotides
Maciej Lukaszewicz,
Aleksandra Ferenc-Mrozek,
Julia Kokosza
et al.
Abstract:The Nudt15 enzyme of the NUDIX protein family is the subject of extensive study due to its action on thiopurine drugs used in the treatment of cancer and inflammatory diseases. In addition to thiopurines, Nudt15 is enzymatically active in vitro on several nucleotide substrates. It has also been suggested that this enzyme may play a role in 5′RNA turnover by hydrolyzing m7GDP, a product of mRNA decapping. However, no detailed studies on this substrate with Nudt15 are available. Here, we analyzed the enzymatic a… Show more
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