Mammalian Sarcoma-Leukemia Viruses. I. Infection of Feline, Bovine, and Human Cell Cultures With Snyder-Theilen Feline Sarcoma Virus

Antiviral Antibiotics: Inhibition of Focus-Formation in Human or Mouse Cell Cultures by Sarcoma-Inducing Oncornaviruses with Rifamycins

“…In contrast, infection of the human embryonic spleen cell culture with FSV that had previously been passaged several times in bovine trachea cell cultures [24] yielded compact foci or morphologically transformed cells ( fig. 2), which were readily counted 7-10 days postinfection, and which shed FSV which could be serially passaged at good titers (> 10' FFU/ml) in such human spleen cultures.…”

“…Previous studies in one of our laboratories (Viral Biology Branch, NCI) on infection of various human cell cultures with the feline leukemia virus pseudotype of murine sarcoma virus (MSV [FLV]) [26] or with FSV propa gated in cat cells [24], generally gave diffuse areas of transformation in these human cultures not amenable to quantitation. In contrast, infection of the human embryonic spleen cell culture with FSV that had previously been passaged several times in bovine trachea cell cultures [24] yielded compact foci or morphologically transformed cells ( fig.…”

“…Both the MSV and FSV virus stocks used in this study have been shown to consist of mixtures of sarcoma viruses and leukemia viruses necessary as helpers for focus production [24]. Accordingly, the particular virus species involved in the antiviral activity, as revealed by the focus assay, are not de fined.…”

Could FIV zoonosis responsible of the breakdown of the pathocenosis which has reduced the European CCR5-Delta32 allele frequencies

“…Moreover, cat zoonoses can be transmitted to man [41,42] and the hypothesis of the role of FIV remains putative. However, the implication of a feline retrovirus could be plausible; indeed, three other species of feline retroviruses, feline foamy virus (FeFV), feline sarcoma virus (FeSV) and Feline leukemia virus (FeLV) can replicate in some human cell cultures with generally production of infectious virus and could sometimes produce morphological cell change [151,[180][181][182][183][184][185][186][187][188][189][190][191][192]. Moreover, cat horizontal transmission of FeLV by cat fleas has also been demonstrated [193] and FeSV can also induce malignant tumours in non felid mammalian including monkeys [194].…”