Mammalian sperm chemotaxis and its association with capacitation

Eisenbach, Michael

doi:10.1002/(sici)1520-6408(1999)25:2<87::aid-dvg2>3.0.co;2-4

Cited by 92 publications

(28 citation statements)

References 51 publications

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“…So far, it has been established that Ca 2+ -signaling play important role in such events. [8][9][10][11][12] Though in general this suggests the importance of different Ca 2+ channels in the context of sperm functions, the molecular identities and nature of the different Ca 2+ channels involved in such functions are not well understood. Different complex Ca 2+ signaling events in general are required for the proper functioning and survival of the sperm cells.…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive ion channel TRPV1 is endogenously expressed in the sperm of a fresh water teleost fish (Labeo rohita) and regulates sperm motility

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Thermosensitive ion channel TRPV1 is endogenously expressed in the sperm of a fresh water teleost fish (Labeo rohita) and regulates sperm motility

et al. 2013

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“…Contributing factors include: (i) paucity of eggs, (ii) heterogeneity of sperm cell populations, and (iii) lack of information on the number and nature of molecules that serve as potential players (1). Unlike many invertebrates and some lower vertebrates, where sperm cell behavior is highly synchronous, at any given moment, only a fraction of mammalian sperm cells seem to respond to components of the egg extracellular matrix, to chemoattractants, or to other signaling molecules (2,3). Thus, sensitive functional bioassays have been difficult or impossible to establish.…”

mentioning

confidence: 99%

A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets

Schultz

Hamra

Garbers

2003

Proc. Natl. Acad. Sci. U.S.A.

512

449

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Understanding mammalian spermatozoan development and the events surrounding fertilization has grown slowly, in part because of uncertainty about the number and identity of the cellular components involved. Determination of those transcripts expressed specifically by germ cells should provide an inclusive list of probable critical proteins. Here, total mouse testis transcript profiles were trimmed of transcripts found in cultures enriched in Sertoli or interstitial cells to yield a germ cell-enriched transcript profile. Monitoring of changes of this profile in the developing testis identified 1,652 genes whose transcript abundance increased markedly coincident with the onset of meiosis. Remarkably, 351 of these genes (Ϸ20%) appear to be expressed only in the male germline. Germ cell-specific transcripts are much less common earlier in testis development. Further analysis of the UniGene EST database coupled with quantitative PCR indicates that Ϸ4% of the mouse genome is dedicated to expression in postmeiotic male germ cells. Most or many of the protein products of these transcripts are probably retained in mature spermatozoa. Targeted disruption of 19 of these genes has indicated that a majority have roles critical for normal fertility. Thus, we find an astonishing number of genes expressed specifically by male germ cells late in development. This extensive group provides a plethora of potential targets for germ cell-directed contraception and a staggering number of candidate proteins that could be critical for fertilization.

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“…24,25 Conversely, in internal-fertilizing species, such as humans, only ,10% of cells are capable of a chemotactic response while swimming towards the source of an attractant (positive gradient), whereas there is no evidence of a visible change in the pattern of movement. [2][3][4]6,16,26 In fact, in our system, the cells that chemotactically swam from W1 (containing spermatozoa) to W2 (containing progesterone) could not be distinguished from the nonchemotactic cells according to the patterns of movement. These features of mammalian sperm chemotaxis make it technically difficult to identify an individual chemotactic cell.…”

Section: Discussionmentioning

confidence: 65%

Human sperm pattern of movement during chemotactic re-orientation towards a progesterone source

Blengini¹,

Teves²,

Uñates³

et al. 2011

Asian J Androl

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Human spermatozoa may chemotactically find out the egg by following an increasing gradient of attractant molecules. Although human spermatozoa have been observed to show several of the physiological characteristics of chemotaxis, the chemotactic pattern of movement has not been easy to describe. However, it is apparent that chemotactic cells may be identified while returning to the attractant source. This study characterizes the pattern of movement of human spermatozoa during chemotactic re-orientation towards a progesterone source, which is a physiological attractant candidate. By means of videomicroscopy and image analysis, a chemotactic pattern of movement was identified as the spermatozoon returned towards the source of a chemotactic concentration of progesterone (10 pmol l 21 ). First, as a continuation of its original path, the spermatozoon swims away from the progesterone source with linear movement and then turns back with a transitional movement that can be characterized by an increased velocity and decreased linearity. This sperm behaviour may help the spermatozoon to re-orient itself towards a progesterone source and may be used to identify the few cells that are undergoing chemotaxis at a given time.

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Mammalian sperm chemotaxis and its association with capacitation

Cited by 92 publications

References 51 publications

Thermosensitive ion channel TRPV1 is endogenously expressed in the sperm of a fresh water teleost fish (Labeo rohita) and regulates sperm motility

Thermosensitive ion channel TRPV1 is endogenously expressed in the sperm of a fresh water teleost fish (Labeo rohita) and regulates sperm motility

A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets

Human sperm pattern of movement during chemotactic re-orientation towards a progesterone source

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