1992
DOI: 10.1152/physrev.1992.72.4.1063
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Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

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Cited by 1,116 publications
(721 citation statements)
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“…APEX1 (APEX nuclease 1), a multifunctional DNA repair enzyme, and MGMT (O-6-methylguanine-DNA methyltransferase), which repairs alkylated guanine in DNA, were up-regulated in our study. In addition, we observed the up-regulation of several genes, which are involved in stress response pathways, like the transcription factor DDIT3 (DNA-damage-inducible transcript 3), several heatshock proteins (HSPA5, HSP90AA1, HSP90B1, HSPB1) and CHKA (Choline kinase alpha) (Welch, 1992;Wang et al, 1996;Chen et al, 1998;Aoyama et al, 2004;van de Water et al 2006). Taken together these gene expression changes are judged to reflect a rather unspecific stress response.…”
Section: Oxidative Stress/ Dna Repair Mechanisms/ Stress Responsementioning
confidence: 81%
“…APEX1 (APEX nuclease 1), a multifunctional DNA repair enzyme, and MGMT (O-6-methylguanine-DNA methyltransferase), which repairs alkylated guanine in DNA, were up-regulated in our study. In addition, we observed the up-regulation of several genes, which are involved in stress response pathways, like the transcription factor DDIT3 (DNA-damage-inducible transcript 3), several heatshock proteins (HSPA5, HSP90AA1, HSP90B1, HSPB1) and CHKA (Choline kinase alpha) (Welch, 1992;Wang et al, 1996;Chen et al, 1998;Aoyama et al, 2004;van de Water et al 2006). Taken together these gene expression changes are judged to reflect a rather unspecific stress response.…”
Section: Oxidative Stress/ Dna Repair Mechanisms/ Stress Responsementioning
confidence: 81%
“…Many studies have suggested a possible correlation between the expression of HSPs and the growth and differentiation of tumor cells [4][5][6][7][8][9]. Recent evidence revealed that considerable expression of HSPs is found in non-heat-shocked cells, showing that HSPs may be induced by other stresses and participated in broader body defense and even in normal growth and development [10]. GRPs was also induced by various stresses to function as molecular chaperones [11], [12].…”
Section: Introductionmentioning
confidence: 99%
“…However, CdSe/ZnS do not release the cadmium ion in intracellular environment, as described by Cho et al 2007. It is known that the expression of HSP70B′ is induced by cadmium ions, but it is also regulated by other cytotoxic stimulations (Schlesinger 1990;Kiang and Tsokos 1998), such as protein denaturation (Welch 1992) or ROS (Ma et al 1998;Gorman et al 1999). Actually, there is no denying that ROS can be generated from the QDs surface (Winnik and Maysinger 2013).…”
Section: Discussionmentioning
confidence: 99%