Mammalian Target of Rapamycin

Wipperman, Matthew F.; Montrose, David C.; Gotto, Antonio M.; Hajjar, David P.

doi:10.1016/j.ajpath.2018.11.013

Cited by 30 publications

(3 citation statements)

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“…The active form of PDK1 then triggers the phosphorylation of protein kinase B (Akt) [ 28 ]. Afterward, the phosphorylated Akt enhances the levels of the mammalian target of rapamycin (mTOR) phosphorylation, resulting in food intake reduction [ 29 ]. The potential molecular mechanisms of the anorexigenic action of insulin are depicted in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices

Antasouras,

Dakanalis,

Chrysafi

et al. 2024

Medical Sciences

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Background: Insulin exerts a crucial impact on glucose control, cellular growing, function, and metabolism. It is partially modulated by nutrients, especially as a response to the intake of foods, including carbohydrates. Moreover, insulin can exert an anorexigenic effect when inserted into the hypothalamus of the brain, in which a complex network of an appetite/hunger control system occurs. The current literature review aims at thoroughly summarizing and scrutinizing whether insulin release in response to glucose exposure may be a better choice to control body weight gain and related diseases compared to the use of sucrose substitutes (SSs) in combination with a long-term, well-balanced diet. Methods: This is a comprehensive literature review, which was performed through searching in-depth for the most accurate scientific databases and applying effective and relevant keywords. Results: The insulin action can be inserted into the hypothalamic orexigenic/anorexigenic complex system, activating several anorexigenic peptides, increasing the hedonic aspect of food intake, and effectively controlling the human body weight. In contrast, SSs appear not to affect the orexigenic/anorexigenic complex system, resulting in more cases of uncontrolled body weight maintenance while also increasing the risk of developing related diseases. Conclusions: Most evidence, mainly derived from in vitro and in vivo animal studies, has reinforced the insulin anorexigenic action in the hypothalamus of the brain. Simultaneously, most available clinical studies showed that SSs during a well-balanced diet either maintain or even increase body weight, which may indirectly be ascribed to the fact that they cannot cover the hedonic aspect of food intake. However, there is a strong demand for long-term longitudinal surveys to effectively specify the impact of SSs on human metabolic health.

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Section: Resultsmentioning

confidence: 99%

Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices

Antasouras,

Dakanalis,

Chrysafi

et al. 2024

Medical Sciences

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“…However, in elderly people mTOR may show the beneficial outcomes of its activity, preventing sarcopenia and lean mass loss. In conclusion, there is a general consensus that this kinase can promote metabolic health or disease depending on human age and on particular signaling of specific tissues [ 72 ].…”

Section: Nutrient Sensors That Potentially Affect Health Spanmentioning

confidence: 99%

Nutrients and Pathways that Regulate Health Span and Life Span

et al. 2020

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Both life span and health span are influenced by genetic, environmental and lifestyle factors. With the genetic influence on human life span estimated to be about 20–25%, epigenetic changes play an important role in modulating individual health status and aging. Thus, a main part of life expectance and healthy aging is determined by dietary habits and nutritional factors. Excessive or restricted food consumption have direct effects on health status. Moreover, some dietary interventions including a reduced intake of dietary calories without malnutrition, or a restriction of specific dietary component may promote health benefits and decrease the incidence of aging-related comorbidities, thus representing intriguing potential approaches to improve healthy aging. However, the relationship between nutrition, health and aging is still not fully understood as well as the mechanisms by which nutrients and nutritional status may affect health span and longevity in model organisms. The broad effect of different nutritional conditions on health span and longevity occurs through multiple mechanisms that involve evolutionary conserved nutrient-sensing pathways in tissues and organs. These pathways interacting each other include the evolutionary conserved key regulators mammalian target of rapamycin, AMP-activated protein kinase, insulin/insulin-like growth factor 1 pathway and sirtuins. In this review we provide a summary of the main molecular mechanisms by which different nutritional conditions, i.e., specific nutrient abundance or restriction, may affect health span and life span.

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“…Moreover, gene expression studies for intramuscular fat in pig identified differentially expressed genes such as RTF1 in OCU17 (Damon et al, 2012) and SLC24A2 in OCU1 (Li et al, 2010). RRGA and RPS6 in OCU1 could stimulate the lipogenesis and the lipid accumulation via activation of the mTOR signalling pathways (Wipperman et al, 2019). PLA2G4B in OCU17 is linked to phospholipid catabolic processes because of its phospholipase A2 (PL2) activity.…”

Section: Underlying Selected Genes and Gene Ontology Terms For Divergmentioning

confidence: 99%

Genomic analysis of divergently selected experimental lines in rabbit

Madrid¹,

Samuel²

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Yo agradezco a "DIOS" y a mi familia, quienes han sido un apoyo fundamental durante el doctorado. "DIOS", tú me ayudaste a tomar la decisión de estudiar en el extranjero y tú has guiado mis pasos principalmente en los momentos difíciles. Mamá, Papá, "Salo" y "Gwendo", gracias por recordarme siempre de dónde vengo, lo que valgo y lo que es importante en la vida. Yo estoy orgulloso de ser panameño, de ustedes, de nuestra cultura, costumbres e idioma. Panamá es un país pequeño lleno de personas que tienen un corazón "sólido" y "sabrosón". También, quiero agradecer al grupo de mejora genética animal de la UPV, a los investigadores principales: María Antonia, Pilar, Agustín y Noelia, por todas sus enseñanzas. Gracias a Agustín por todo durante este tiempo de mi doctorado. Un especial gracias a Noelia, por el tiempo que dedicaste a enseñarme genómica estadística; realmente aprecio todo lo que has hecho por mí a nivel personal. Gracias a todos mis compañeros del Instituto de Ciencia y Tecnología Animal. Un millón de gracias a los compañeros de genética, Marina Martínez, Agostina, Cristina, "Mafe", Enrico, David, Ana y los demás, quienes me acompañaron en estos últimos cuatro años. También quiero agradecer a los compañeros del grupo de acuicultura, Víctor "El Pastor", German, Guillem, Miriam y los demás. También gracias Richard, Ximo y Andrea por las graciosas conversaciones. Thanks to all my colleagues from the Institute for Animal Science and Technology. Thanks a million to fellows of the Group of Animal Breeding, Marina Martínez, Agostina, Cristina, "Mafe", Enrico, David, Ana and other fellows. I am also thankful to the colleagues of the Aquaculture Group, Victor "El Pastor", German, Guillem, Miriam and the others. I would also like to thank Richard, Ximo and Andrea for the funny conversations. I must express a special thanks to Federico, Veronica, Marina Morini, Antonella, Ilaria and Rosalia, for working with me in the experiments at the rabbit farm and the meat lab; especially to Marina, my principal workmate over tough five months. You were present when I said my famous phrase "How disgusting my life". I will not forget it. I would like to thank John Hickey and your group, particularly to Roger and Mara, for your time invested in my learning during my first stay in Edinburgh. That time was and will be a special memory for me. Thanks to Chris Haley and your group, particularly to Pau, Yanni, Charlie and Carmen, thanks a million, since I learnt with you a lot of GWAS and work as a team. That stay exceeded my expectation. I would like to thank Luis Varona for teaching methods of selection signatures, and also, for showing me the phenomenal Zaragoza. Thanks to "Froy", Maru, Leonela and other friends in Panama for your support in the last four years. To Jeffry, Judith, Latifa and Kenza, thanks a million, since you were an essential piece to keep going with my doctorate. Thanks to my friends that I knew in Edinburgh: Piotr, Dariuz, Alberto, Yuyao y Liam, thanks a million, I was happy with you during my long stay in beaut...

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Mammalian Target of Rapamycin

Cited by 30 publications

References 100 publications

Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices

Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices

Nutrients and Pathways that Regulate Health Span and Life Span

Genomic analysis of divergently selected experimental lines in rabbit

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