Mammary analogue secretory carcinoma presenting as a cystic parotid mass

Gupta, Karisma; Patwa, Hafiz S.; Niehaus, Angela G.; Filho, Gileno O.F.; Läck, Christopher M.

doi:10.1016/j.radcr.2019.06.019

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…Out of a total of 226 studies published between 2010 and 2023, identified at initial search and screened for retrieval, 112 1–3,6–114 articles were included in the study, with a total of 674 patients described in these articles. The identification and screening process is described in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis

Yosefof,

Boldes,

Dan

et al. 2023

The Laryngoscope

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ObjectivesSecretory Carcinoma is a malignant salivary gland tumor, initially described in 2010. This rare tumor is associated with the translocation t(12;15) (p13;q25), resulting in the fusion gene ETV6‐NTRK3. Since this tumor is quite rare, most publications describe only small cohorts of patients. We aimed to investigate the clinical, pathological, and prognostic features of this newly defined malignant entity.Data SourcesPubmed, Google Scholar, and Web of Science databases.Review MethodsAll published articles between 2010 and 2023 were reviewed. Search terms included the terms “Mammary Analogue Secretory Carcinoma” and “Secretory Carcinoma”. All articles published in English reporting on Secretory Carcinoma of salivary glands were retrieved.ResultsOne‐hundred and 12 retrospective articles reporting a total of 674 patients were included, with 52% males and a mean age of 44.9 ± 18.9. The event rate for patients with advanced‐stage disease (Stage 3/4) at presentation was 24.1% (95% CI 17.6%–31.9%, I2 = 9.2%), 14.6% for regional metastases (95% CI 10.5%–20%, I2 = 12%), and the event rate of distant metastasis was 8.4% (95% CI 5.5%–12.7%, I2 = 4.2%). Adjuvant radiotherapy was administered for 30.3% of patients (95% CI 24.1%–37.2%, I2 = 21.5%). The recurrence rate was 19% (95% CI 15.1%–23.8%, I2 = 5%). Survival outcomes showed a 17.2% death of disease rate for Secretory Carcinoma patients (95% CI 13.5%–21.8%, I2 = 7.3%).ConclusionsSecretory Carcinoma is a rare and relatively newly defined entity arising in the parotid gland most commonly. Characterized as a low‐grade tumor, the majority of patients are diagnosed at an early stage, without regional or distant disease, and the prognosis is relatively good.Level of EvidenceN/A Laryngoscope, 2023

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Section: Resultsmentioning

confidence: 99%

Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis

Yosefof,

Boldes,

Dan

et al. 2023

The Laryngoscope

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“…14 Siderophages and blood in the background are common. Few cases of SC clinically present with a cystic mass, 4,18,19 and all of them occurred in the parotid gland. However, our case of lymph node SC, presenting as a lateral neck cystic mass, is quite unique from this point of view.…”

Section: F I G U R Ementioning

confidence: 99%

Secretory carcinoma of salivary type in a lymph node presenting as a neck cyst diagnosed by cytology: A case report

Hrudka

Drozenová

Sýba

et al. 2020

Diagnostic Cytopathology

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Secretory carcinoma (SC) is a relatively recently described salivary gland adenocarcinoma characterized by ETV6‐NTRK3 gene fusion and, in most cases, indolent clinical behavior. Morphologically, the tumor shows a glandular architecture and the presence of monophasic tumor cells with vacuolated cytoplasm, low‐grade nuclear atypia, and mucin production, with possibly a tubular, papillary, or cystic arrangement. In this article, we describe a case of a 52‐year old man with SC involving a neck lymph node clinically manifesting as a slowly growing cystic neck mass without recent proof of the primary tumor, but with a history of a parotid gland “cystadenopapilloma,” which had been removed 35 years prior. A fine‐needle aspiration biopsy revealed a diagnosis of SC. Subsequent histopathological examination after lymph node dissection confirmed the diagnosis. The tumor showed typical features of SC, including immunohistochemical positivity for NTRK and NTRK3 gene rearrangement, detected using in situ hybridization. We discuss that the tumor may be a late metastasis occurring 35 years after resection of undiagnosed salivary SC or a primary SC arising from heterotopic salivary tissue within a lymph node. Differential diagnostic considerations and review of relevant literature are included.

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Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta‐analysis

et al. 2021

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Mammary analogue secretory carcinomas (MASCs) of the parotid gland are considered as low‐grade malignancies with good clinical outcome but lacking data regarding prognostic factors. We performed meta‐analysis assessing prognostic factors for disease‐free survival (DFS) and overall survival (OS) in 256 patients with MASCs of the parotid gland. A total of 73 studies have met the inclusion criteria and 76.3% of patients were seen with T1 and T2 tumors and negative neck nodes. Lymph node metastasis (57.4%) and distant recurrences (46.2%) were particularly found in T4 tumors (p < 0.001). DFS at 5 and 10 years was 77.9% and 47.2% compared to 88.1% and 77.2% for OS at the same time points. Male sex, T3‐T4 tumors, and recurrent disease represented independent worse prognosticators for survival outcome. Altogether, parotid gland MASCs show good long‐term outcome, but T4 tumors behave significantly more aggressive and require extended treatment strategies along with close follow‐ups.

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Mammary analogue secretory carcinoma presenting as a cystic parotid mass

Cited by 6 publications

References 16 publications

Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis

Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis

Secretory carcinoma of salivary type in a lymph node presenting as a neck cyst diagnosed by cytology: A case report

Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta‐analysis

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