Mammary and extramammary Paget's disease

Androgen receptors are frequently expressed in mammary and extramammary Paget's disease

“…2,3 A current theory proposes that the tumor cells of extramammary Paget's disease originate either from the intraepidermal cells of apocrine gland ducts or from pluripotent keratinocyte stem cells. 4 Recently, vulvar extramammary Paget's disease has been classified based on the origin of neoplastic Paget cells as either primary (of cutaneous origin) or secondary (of non cutaneous origin). 5 Mammary Paget's disease and primary extramammary Paget's disease are currently treated surgically.…”

Perianal Extramammary Paget’s Disease: Diagnosis, Treatment and Prognosis

“…Pruritus is the most common presenting symptom. Because of its non-specific features, perianal EMPD could be misdiagnosis as an infective or inflammatory skin status, such as eczema or contact dermatitis [8].…”

Treatment of vulvar Paget disease with topical imiquimod: a case report and review of the literature

“…2 Since recurrence rates between 16-50% are seen after regular surgery, 15 Mohs micrographic surgery has become the preferred treatment modality for EMPD. 16 Despite this, recurrences rates of 27% following Mohs surgery have been reported.…”

“…The well-known association of EMPD with underlying malignancy contributes also to the therapeutic challenge. 2 Current recommended treatments for EMPD are surgical excision, preferably Mohs' micrographic surgery, laser ablation, electrodessication and curettage, photodynamic therapy, radiotherapy as well as topical use of 5-fluorouracil. 3 Topical application of imiquimod 5% cream has been reported in the last years with successful results.…”