Mammary cancer risk and serum lipid profile of rats supplemented with pomegranate seed oil and bitter melon extract

Lepionka, Tomasz; Białek, Agnieszka; Białek, Małgorzata; Czauderna, M.; Stawarska, Agnieszka; Wrzesień, R.; Bielecki, Wojciech; Paśko, Paweł; Galanty, Agnieszka; Bobrowska-Korczak, Barbara

doi:10.1016/j.prostaglandins.2019.03.005

Cited by 19 publications

(36 citation statements)

References 60 publications

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“…Some randomly selected tumours were fixed in 10% formalin solution and subjected to histopathological examination, whereas the remaining tumours were stored in −80 • C for further analysis. A histopathological picture of tumours for CONplus, Gplus and Mplus groups corresponded to intraductal papillary adenoma, while tumours from the GM group corresponded to ductal adenoma [28].…”

Section: Animalsmentioning

confidence: 96%

“…Before administration to animals it was brought to ambient temperature and after that administered to the animals via gavage, in the amount of 0.15 mL per animal daily. Total characteristics of PSO was given previously [28,29].…”

Section: Pomegranate Seed Oil (Pso)mentioning

confidence: 99%

“…A detailed description of the whole experiment was given previously [28]. The experiment and the guiding principles for the use and care of laboratory animals were approved by the II Local Ethical Committee on Animal Experiments in Warsaw (54/2015).…”

Section: Animalsmentioning

confidence: 99%

“…Throughout the whole experiment animals were provided ad libitum access to a standard laboratory fodder Labofeed H (Feed and Concentrates Production Plant, A. Morawski,Żurawia 19, Kcynia, Poland) and drinking liquid. The detailed composition of Labofeed H fodder and applied dietary supplements was published previously [28]. After an adaptation period (7 days), rats were randomly divided into eight equinumerous groups.…”

Section: Animalsmentioning

confidence: 99%

“…Analyses were performed with a gas chromatograph (GC-17A Shimadzu, Kyoto, Japan) equipped with a capillary column (BPX 70; 60 m × 0.25 mm i.d., film thickness 0.20 µm, SGE, Ringwood, Australia) and a flame-ionisation detection (FID). Detailed conditions were described previously [28]. FA methyl esters (FAME) standards (Supelco 37 Component FAME Mix, Sigma, St. Louis, MO, USA), CLA FAME reference standard (Nu-Chek-Prep, INC., Elysian, MN, USA), PA methyl ester reference standard (Methyl punicate, Matreya LLC, State College, PA, USA) were used to identify the FA present in samples.…”

Section: Fa Analysis In Serummentioning

confidence: 99%

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The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours

et al. 2020

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The aim of this study was to present overall lipid profile of organisms with ongoing neoplastic process and applied diet supplementation with pomegranate seed oil (PSO) and bitter melon extract (BME). The following were quantified in serum and cancerous tissues of rats suffering from mammary tumours: fatty acids, conjugated fatty acids and sterols, their oxidised metabolites (malondialdehyde and oxysterols) and lipoxygenase (LOX) metabolites of polyunsaturated fatty acids. The obtained results indicate that abnormalities in lipid metabolism accompany neoplastic process. These differences concern all classes of lipids and most pathways of their transformation, with the special emphasis on lipid peroxidation and LOX-mediated metabolism. Cancer process appears to be so detrimental that it may conceal positive influence of dietary modifications. The lack of anticarcinogenic properties of PSO and BME in this model may be due to their antioxidant properties or elevated levels of conjugated linoleic acids (CLA), which change CLA isomer activity from anti- to pro-tumorigenic. As CLA are the product of conjugated linolenic acids (CLnA) endogenous metabolism, high CLA levels may be explained by applied diet enrichment.

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Section: Animalsmentioning

confidence: 96%

Section: Pomegranate Seed Oil (Pso)mentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

Section: Fa Analysis In Serummentioning

confidence: 99%

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The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours

et al. 2020

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A review of experimental and clinical studies on the therapeutic effects of pomegranate (Punica granatum) on non‐alcoholic fatty liver disease: Focus on oxidative stress and inflammation

Zamanian,

Sadeghi Ivraghi,

Khachatryan

et al. 2023

Food Science & Nutrition

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Non‐alcoholic fatty liver disease (NAFLD) is frequently linked to metabolic disorders and is prevalent in obese and diabetic patients. The pathophysiology of NAFLD involves multiple factors, including insulin resistance (IR), oxidative stress (OS), inflammation, and genetic predisposition. Recently, there has been an emphasis on the use of herbal remedies with many people around the world resorting to phytonutrients or nutraceuticals for treatment of numerous health challenges in various national healthcare settings. Pomegranate (Punica granatum) parts, such as juice, peel, seed and flower, have high polyphenol content and is well known for its antioxidant capabilities. Pomegranate polyphenols, such as hydrolyzable tannins, anthocyanins, and flavonoids, have high antioxidant capabilities that can help lower the OS and inflammation associated with NAFLD. The study aimed to investigate whether pomegranate parts could attenuate OS, inflammation, and other risk factors associated with NAFLD, and ultimately prevent the development of the disease. The findings of this study revealed that: 1. pomegranate juice contains hypoglycemic qualities that can assist manage blood sugar levels, which is vital for avoiding and treating NAFLD. 2. Polyphenols from pomegranate flowers increase paraoxonase 1 (PON1) mRNA and protein levels in the liver, which can help protect liver enzymes and prevent NAFLD. 3. Punicalagin (PU) is one of the major ellagitannins found in pomegranate, and PU‐enriched pomegranate extract (PE) has been shown to inhibit HFD‐induced hyperlipidemia and hepatic lipid deposition in rats. 4. Pomegranate fruit consumption, which is high in antioxidants, can decrease the activity of AST and ALT (markers of liver damage), lower TNF‐α (a marker of inflammation), and improve overall antioxidant capacity in NAFLD patients. Overall, the polyphenols in pomegranate extracts have antioxidant, anti‐inflammatory, hypoglycemic, and protective effects on liver enzymes, which can help prevent and manage NAFLD effects on liver enzymes, which can help prevent and manage NAFLD.

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Harnessing the potential of bitter gourd seeds for food and nutrition- A comprehensive review

Abbas,

Shabbir,

Haq

et al. 2024

Applied Food Research

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Mammary cancer risk and serum lipid profile of rats supplemented with pomegranate seed oil and bitter melon extract

Cited by 19 publications

References 60 publications

The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours

The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours

A review of experimental and clinical studies on the therapeutic effects of pomegranate (Punica granatum) on non‐alcoholic fatty liver disease: Focus on oxidative stress and inflammation

Harnessing the potential of bitter gourd seeds for food and nutrition- A comprehensive review

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