Mammary carcinoma in a geriatric alpaca

Faivre, Cosette M.; Harm, Tyler; Smith, Joe S.; Haynes, Joseph S.; Dohlman, Tyler M.

doi:10.1002/vrc2.30

Cited by 1 publication

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“…Future directions for prednisonolone in alpacas include pharmacodynamic studies. One key area for further pharmacodynamic investigation is the use of prednisolone for anti-neoplastic therapy, considering the alpaca's role as a primarily companion animal, and the propensity of older alpacas to develop cancer (24,38,39). Additional research is needed to elucidate the effects that body condition could have on the pharmacokinetics of prednisolone in alpacas, as overconditioning (increased body fat percentage) in some species, such as cats, is associated with higher serum concentrations (40).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Orally Administered Prednisolone in Alpacas

et al. 2021

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This study aimed to determine the pharmacokinetics of prednisolone following intravenous and oral administration in healthy adult alpacas. Healthy adult alpacas were given prednisolone (IV, n = 4), as well as orally (PO, n = 6). Prednisolone was administered IV once (1 mg/kg). Oral administration was once daily for 5 days (2 mg/kg). Each treatment was separated by a minimum 4 month washout period. Samples were collected at 0 (pre-administration), 0.083, 0.167, 0.25, 0.5, 0.75, 1, 2, 4, 8, 12, and 24 h after IV administration, and at 0 (pre-administration), 0.25, 0.5, 0.75, 1, 2, 4, 8, 12, 24 after the first and 5th PO administration. Samples were also taken for serial complete blood count and biochemistry analysis. Prednisolone concentration was determined by high pressure liquid chromatography. Non-compartmental pharmacokinetic parameters were then determined. After IV administration clearance was 347 mL/kg/hr, elimination half-life was 2.98 h, and area under the curve was 2,940 h*ng/mL. After initial and fifth oral administration elimination half-life was 5.27 and 5.39 h; maximum concentration was 74 and 68 ng/mL; time to maximum concentration was 2.67 and 2.33 h; and area under the curve was 713 and 660 hr*ng/mL. Oral bioavailability was determined to be 13.7%. Packed cell volume, hemoglobin, and red blood cell counts were significantly decreased 5 days after the first PO administration, and serum glucose was significantly elevated 5 days after the first PO administration. In conclusion, serum concentrations of prednisolone after IV and PO administration appear to be similar to other veterinary species. Future research will be needed to determine the pharmacodynamics of prednisolone in alpacas.

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Section: Discussionmentioning

confidence: 99%