Mammary Gland Tumors in Captive African Hedgehogs

Raymond, James T.; Garner, Michael M.

doi:10.7589/0090-3558-36.2.405

Cited by 31 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mammary neoplasms are one of the most commonly reported, occurring as solitary or multiple nodules, with benign and malignant variants. In a previous case series, mammary tumors in this species have been classified as papillary adenoma or tubular, solid or papillary carcinomas (12).…”

Section: Discussionmentioning

confidence: 99%

“…More than one tumor type is reported to occur in less than 10% of hedgehogs with neoplasia, and include thyroid follicular adenoma and concurrent multicentric skeletal sarcoma, adrenocortical carcinoma and concurrent mandibular osteosarcoma, among others (6). Simultaneous tumors have also been reported in animals with mammary tumors, and include cutaneous mast cell tumor, hemangiosarcoma, oral squamous cell carcinoma, sebaceous carcinoma, uterine leiomyoma, uterine adenocarcinoma and ovarian granulosa cell tumor (8,12,18). Whether this association is coincidental, due to the high prevalence of mammary tumor in these species, or has a common oncogenic pathway is not clear.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Estrogen and progesterone receptors immunolabeling in mammary solid carcinoma in an African Hedgehog (Atelerix albiventris) with concurrent uterine fibrosarcoma

Fernandes

Réssio

Guerra

et al. 2017

Braz. J. Vet. Pathol.

View full text Add to dashboard Cite

Fernandes, et al.; Estrogen and progesterone receptors immunolabeling in mammary solid carcinoma in an African Hedgehog (Atelerix albiventris) with concurrent uterine fibrosarcoma. Braz J Vet Pathol, 2017, 10(1), 38 -42. DOI: 10.24070/bjvp.1983 Brazilian AbstractThe African Hedgehog (Atelerix albiventris) has gained popularity as a pet in several parts of the world. This is a report of a concomitant finding of spontaneous mammary and uterine tumors in an adult female African Hedgehog. The animal presented abdominal masses and died suddenly. Upon necropsy, not only the mammary tumor mass, but also a uterine neoplasm was found. Formalin fixed and paraffin embedded tissues were submitted for histopathological examination. The mammary tumor was diagnosed as a solid carcinoma, and the uterine tumor as fibrosarcoma. By immunohistochemistry, the mammary tumor showed positivity for pancytokeratins and estrogen and progesterone receptors, while the uterine neoplasm exhibited positivity for vimentin. There was high cross-immunoreactivity between anti-human antibodies. The positivity for hormonal receptors antigens may represent a relationship between estrogen and progesterone levels and the development of mammary tumors, as in other mammals.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Estrogen and progesterone receptors immunolabeling in mammary solid carcinoma in an African Hedgehog (Atelerix albiventris) with concurrent uterine fibrosarcoma

Fernandes

Réssio

Guerra

et al. 2017

Braz. J. Vet. Pathol.

View full text Add to dashboard Cite

show abstract

“…Neoplasms in wild animals have been a theme frequently discussed in the veterinary practice (Bertelsen et al 2011, Guthrie & Maar 2011, especially because an improve in the longevity of the wild species raised under captive conditions was achieved during the last years (Cullen et al 2002). Neoplasms can cause high levels of morbidity and mortality, and, efforts have been done to identify the predisposing factors (Ramond & Garner 2000). In spite of the increase in the number of studies involving neoplasm in wild animals, there is yet a lack of information about neoplasms in collared peccaries (P. tajacu).…”

Section: Introductionmentioning

confidence: 99%

Extramedullary plasmacytoma in a captive collared peccary (Pecari tajacu)

et al. 2016

View full text Add to dashboard Cite

RESUMO.-[Plasmocitoma extramedular em cateto criado em cativeiro (Pecari tajacu).]Um caso de plasmocitoma extramedular em cateto criado em cativeiro (Pecari tajacu) está sendo relatado. O animal, uma fêmea com três anos de idade, apresentou um histórico médico de lesões de pele, envolvendo junção mucocutânea e de aumento de linfonodos. Exame clínico e exames complementares (hemograma completo, análise bioquímica, raspado de pele para pesquisa de ácaros e cultura fúngica) foram realizados. Após 30 dias, o animal morreu. Na necropsia, verificou-se a presença de múltiplos nódulos, pústulas assépticas e aumento dos linfonodos. Na pele e mucosa oral, histologicamente as massas consistiam em ninhos, lençóis e cordões de células redondas, e um estroma fibrovascular bem vascularizado. Os plasmócitos foram observados infiltrados entre as fibras e músculo liso da lâmina pró-pria. Espaços contendo eosinófilos, fluido e células livres estavam presentes na massa. A maioria das células estava bem diferenciada, com uma zona perinuclear clara, mas algumas células demonstraram-se pleomórficas. Os plasmócitos apresentavam núcleo excêntrico, redondo, basófi-lo, e pontilhado, com cromatina variando de densa a grosseiramente organizada e nucléolos distintos. O citoplasma Extramedullary plasmacytoma in a captive collared peccary (Pecari tajacu) An extramedullary plasmacytoma case in a captive collared peccary (Pecari tajacu) is reported. The animal, a female aging three years old, had a medical history of diffusely distributed skin and mucocutaneous junction lesions, associated with swollen lymph nodes. Clinical examination and complementary exams (complete blood count, biochemical analysis, skin scraping to search mites and fungal culture) were performed. Thirty days after examination, the animal died. At necropsy, multiple consistent nodules, aseptic pustules and swollen lymph nodes were found. On histological exams of the skin and oral mucosa, we observed a large number of round cells forming masses organized in nests, sheets, and cords of cells in a well-vascularized fibrovascular tissue. Neoplastic plasma cells infiltrated between the fibers and the lamina propria of smooth muscle. Spaces among the cell masses were filled with some eosinophil and fluid. Most of the cells were well differentiated, presenting a perinuclear clear zone. In some points, the cells were pleomorphic. The plasma cells presented eccentric, basophilic and spherical nuclei, showing a dense to organized chromatin with distinct nucleoli. Binucleate cells were observed, but multinucleated giant cells were rare. Oral mucosa and lymph nodes tested by immunohistochemical analyses were positive for Mb-1, with a multifocal distribution. In regard to Bcl-2, the neoplastic cells were intermittent weakly positive. So, an extramedullary plasmacytoma was diagnosed in the collared peccary considering the location, the histopathological and immunohistochemical findings. finamente granular de anfifílico para basofílico. As células foram interpretadas como plasmócitos neopl...

show abstract

“…The presence of multiple tumor types in a hedgehog is not unusual. 21,22 In summary, 2 subcutaneous spindle cell sarcomas consistent with malignant peripheral nerve sheath tumor and a vaginal spindle cell sarcoma are described in this report. With the exception of an undifferentiated subcutaneous sarcoma, 22 soft tissue sarcomas have not been reported in hedgehogs.…”

mentioning

confidence: 99%

“…Cutaneous squamous cell carcinoma, mast cell tumor, pituitary adenoma, myelogenous leukemia, sarcomas, intestinal lymphosarcoma, intestinal plasmacytoma, renal transitional cell carcinoma, hepatic adenoma, oral carcinoma, poorly differentiated subcutaneous sarcoma, subcutaneous neurofibroma, and mammary neoplasms have been reported. 3,4,10,14,17,19,[20][21][22][23][24] Microscopically, both cutaneous tumors had features of neurofibrosarcoma. 11 Neurofibrosarcomas are also called neurogenic sarcoma, malignant schwannoma, and more recently, malignant peripheral nerve sheath tumor (MPNST).…”

mentioning

confidence: 99%

Soft Tissue Sarcomas in the African Hedgehog (Atelerix Albiventris): Microscopic and Immunohistologic Study of Three Cases

Ramos-Vara

2001

J VET Diagn Invest

View full text Add to dashboard Cite

Abstract. Three soft tissue tumors from 2 female hedgehogs were examined microscopically and immunohistochemically. Two tumors involved haired skin and the third one was vaginal. Microscopically, the cutaneous tumors had features of malignant peripheral nerve sheath tumor (MPNST), whereas the vaginal tumor was classified only as a spindle cell sarcoma. Immunohistochemically, all 3 tumors were strongly positive for vimentin and strongly to moderately positive for CD10 and neuron-specific enolase but did not stain with antibody to S100 protein, an antigen typically present in human MPNST. The cutaneous tumor from hedgehog no. 1 was examined ultrastructurally and the neoplastic cells resembled fibroblasts. Hedgehog no. 1 was euthanized at the time of the biopsy. The outcome of the other hedgehog was unknown.African hedgehogs (Atelerix albiventris) are popular exotic pets. Consequently, there is demand for information regarding their husbandry and diseases. 22 Neoplastic diseases constitute approximately 30% of the histopathologic diagnoses made in hedgehogs. 22 A search of the Veterinary Medical Diagnostic Laboratory (VMDL), Columbia, MO, database (1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000) found 40 accessions of hedgehogs with histopathologic exam. Sixty-three percent of the cases were nonneoplastic, 37% were neoplastic. This report describes the morphologic and immunohistochemical features of 3 spindle cell sarcomas in 2 African hedgehogs. Case no. 1 was a 4.5-month-old female African hedgehog, which developed a mass on the medial aspect of the right foreleg. The hedgehog was euthanized at the owner's request. The 3-cm-diameter mass and multiple organs were collected by the referring veterinarian for histopathologic examination at the VMDL. Case no. 2 was a 3-year-old female African hedgehog with a mass in the right lumbar skin and another mass in the vagina, which were excised and sent to the VMDL for histopathologic examination.Tissues were fixed for an undetermined period in 10% buffered formalin and embedded in paraffin. Five-micrometer sections were stained with HE and Masson trichrome. For immunohistochemistry, paraffin sections were placed on positively charged slides and stained with antibodies to vimentin, a smooth muscle-specific actin, a muscle-specific actin, a desmin, a CD10, b S100 protein, a neuron-specific enolase, a chromogranin A, a synaptophysin, a glial fibrillary acidic protein, a and factor VIII-related antigen a following described methods. 18 Immunohistochemical staining was performed in From the Veterinary

show abstract

Mammary Gland Tumors in Captive African Hedgehogs

Cited by 31 publications

References 16 publications

Estrogen and progesterone receptors immunolabeling in mammary solid carcinoma in an African Hedgehog (Atelerix albiventris) with concurrent uterine fibrosarcoma

Estrogen and progesterone receptors immunolabeling in mammary solid carcinoma in an African Hedgehog (Atelerix albiventris) with concurrent uterine fibrosarcoma

Extramedullary plasmacytoma in a captive collared peccary (Pecari tajacu)

Soft Tissue Sarcomas in the African Hedgehog (Atelerix Albiventris): Microscopic and Immunohistologic Study of Three Cases

Contact Info

Product

Resources

About