Mammary invasive duct carcinoma metastatic to parotid gland: Report of a case diagnosed by fine‐needle aspiration

Laforga, Juan B.; Gasent, Joan M.

doi:10.1002/dc.21010

Cited by 13 publications

(22 citation statements)

References 12 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The salivary gland FNABs in these cases showed a uniform pattern of cells with low‐grade to intermediate‐grade nuclear features. This cell population can be difficult to distinguish from salivary gland ductal cells, but ancillary studies, such as GATA binding protein 3 (Gata‐3), estrogen receptor/progesterone receptor, and mammaglobin could be helpful …”

Section: Discussionmentioning

confidence: 99%

“…This cell population can be difficult to distinguish from salivary gland ductal cells, but ancillary studies, such as GATA binding protein 3 (Gata-3), estrogen receptor/progesterone receptor, and mammaglobin could be helpful. 2,7,37,38 The nonspecific malignant group consisted of 21 patients. 39,40 The differential diagnoses for tumors in this group included both metastatic and primary tumors of the salivary gland, particularly mucoepidermoid carcinoma (MEC); this was particularly true for a difficult SMSG case of pulmonary mucinous ADC.…”

Section: Smsgs With Diagnostic Difficulties and Rare Smsgsmentioning

confidence: 99%

See 1 more Smart Citation

FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases

Wang

Hoda

Faquin

et al. 2016

Cancer Cytopathology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Smsgs With Diagnostic Difficulties and Rare Smsgsmentioning

confidence: 99%

FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases

Wang

Hoda

Faquin

et al. 2016

Cancer Cytopathology

View full text Add to dashboard Cite

show abstract

“…Head and neck tumors make up to two-thirds of these metastases, squamous cell carcinoma and malignant melanomas from the upper airway and the foregut being the most common, followed by the skin [7]. However, metastases from distal primaries such as the breast, GI tract, kidneys, and prostate are quite rare and thought to reach the parotids through the thoracic duct or Batson's paraspinal venous plexus, skipping the pulmonary filter [8].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, salivary ductal carcinoma has been reported to express almost invariably androgen receptors [19]. Comparing the hormone receptors immunoprofile of both the parotid tumor and the primary breast tumor can be helpful although phenotypic discrepancies regarding the expression of hormone receptors between primary tumor and metastasis have been described in up to 25% of cases [7]. …”

Section: Discussionmentioning

confidence: 99%

“…Shi et al advocate the use of an ipsilateral neck dissection when the metastasis is from head and neck primaries as spread occurred predominantly via the lymphatic system, whereas, in cases of hematogenous spread from distant sites, neck dissection is thought to be unnecessary. Adjuvant radiotherapy to the parotid and neck is recommended by most authors for patients without nodal involvement; however, others favor the use of adjuvant chemotherapy, the rationale behind it being the possible coexistence of occult and microscopic metastasis, reserving the use of irradiation for cases where local control could not be achieved by surgery alone [7]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metachronous, Single Metastasis to the Parotid, from Primary Breast Cancer: A Case Report and Review of the Literature

Kmeid

Kamar

Nasser

et al. 2016

Case Reports in Oncological Medicine

View full text Add to dashboard Cite

Background. The parotid gland is an unusual site for metastatic disease and when metastasis occurs, it commonly originates from head and neck primaries. Spread from distant infraclavicular sites such as the breast, into the parotid, is even more unusual with very few cases reported in the literature. Case Report. We describe the case of a 65-year-old woman presenting for a rapidly enlarging right parotid mass. She had a history of an invasive ductal carcinoma of the right breast and was disease-free in the past 6 years prior to her presentation. She was thereafter diagnosed as having a solitary parotid metastasis from breast origin. A total parotidectomy was done and she was referred for adjuvant radiotherapy. Conclusion. Any parotid metastasis should be investigated, especially in patients with a prior history of cancer where the possibility of metastasis, even if improbable, should be kept in mind. Fine needle aspiration biopsy (FNAB) is the first diagnostic procedure to be done and immunocytochemistry can provide valuable information even if it is not always needed for diagnosis. Superficial parotidectomy when feasible with adjuvant radiotherapy is the preferred approach for solitary metastasis of the parotid. The prognosis, however, remains poor regardless of the treatment modality used.

show abstract

Fine‐needle aspiration cytological findings in three cases of metastatic amelanotic melanoma to the parotid gland with divergent differentiation

Laforga¹

2021

Diagnostic Cytopathology

Self Cite

View full text Add to dashboard Cite

This report presents the clinical and pathologic findings of three cases of metastatic amelanotic melanoma to the parotid gland. Two of the patients had a primary cutaneous tumor. Fine‐needle aspiration of the parotid showed clusters of epithelioid cells and/or spindle‐shaped cells with vesicular nuclei, macronucleoli, and abundant eosinophilic cytoplasm. In addition, one had striking balloon‐cell features. In the immunohistochemical study, the tumors expressed S‐100, HMB‐45 antigen, Melan‐A, and SOX10, and focally smooth‐muscle actin, cytokeratin, CD56, p63, and synaptophysin. The diagnosis was challenging because the tumors were clinically thought to be primary parotid lesion and showed unusual immunohistochemical labeling for SMA, cytokeratins, p63, and neuroendocrine markers. Furthermore, the long clinical history in two of the cases made the diagnosis of a metastatic lesion less likely. Diagnostic errors can be reduced by integrating cytomorphologic, histologic, immunohistochemical, and clinical findings.

show abstract

Mammary invasive duct carcinoma metastatic to parotid gland: Report of a case diagnosed by fine‐needle aspiration

Cited by 13 publications

References 12 publications

FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases

FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases

Metachronous, Single Metastasis to the Parotid, from Primary Breast Cancer: A Case Report and Review of the Literature

Fine‐needle aspiration cytological findings in three cases of metastatic amelanotic melanoma to the parotid gland with divergent differentiation

Contact Info

Product

Resources

About