Mammary Malignant Ulcer after Radiotherapy: Unpleasant Surprise

Abstract

Summary:We present a case of a woman, 79 years old, followed by Psychiatry for depressive episodes after breast cancer removal. She was operated on for ductal breast carcinoma in 1983. Afterward she was submitted to adjuvant radiotherapy. She came to our attention for a chronic skin ulcer that developed into the radio-treated area about 4 years ago. We performed a skin biopsy and programed adipose tissue grafts to promote wound healing. The result of the biopsy was unexpected: dermal localization of not differentiated breast carcinoma. She is currently under systemic chemotherapy treatment. The key message is to always perform a skin biopsy of a chronic skin ulcer developed after breast cancer removal before planning surgical reconstruction.

Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells

“…The radiation dose is determined by the sensitivity of the tumor and surrounding tissues (36). Oral mucositis is a crucial dose-limiting toxic effect in radiotherapy for head and neck cancers (37), and skin ulcers are a common side effect in patients with breast cancer (38,39). Radiotherapy induces DNA strand breaks, ROS production, and oxidative stress that eventually trigger cell senescence and amplify acute damage (9,40,41).…”